Peptide Antiviral Strategies as an Alternative to Treat Lower Respiratory Viral Infections von Nyanguile, Origène

Volltext

Peptide Technologies at Energypolis von Mathieu, Marc, Nyanguile, Origène

Volltext

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release von Postupalenko, Viktoriia, Marx, Léo, Pantin, Mathilde, Viertl, David, Gsponer, Nadège, Giudice, Gaëlle, Gasilova, Natalia, Schottelius, Margret, Lévy, Frédéric, Garrouste, Patrick, Segura, Jean-Manuel, Nyanguile, Origène

Volltext

A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading von Gaillard, Vanessa, Galloux, Marie, Garcin, Dominique, Eléouët, Jean-François, Le Goffic, Ronan, Larcher, Thibaut, Rameix-Welti, Marie-Anne, Boukadiri, Abdelhak, Héritier, Julien, Segura, Jean-Manuel, Baechler, Elodie, Arrell, Miriam, Mottet-Osman, Geneviève, Nyanguile, Origène

Volltext

Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice von Galloux, Marie, Gsponer, Nadège, Gaillard, Vanessa, Fenner, Brice, Larcher, Thibaut, Vilotte, Marthe, Rivière, Julie, Richard, Charles-Adrien, Eléouët, Jean-François, Le Goffic, Ronan, Mettier, Joelle, Nyanguile, Origène

Volltext

Template directed synthesis of antibody Fc conjugates with concomitant ligand release von Postupalenko, Viktoriia, Marx, Léo, Viertl, David, Gsponer, Nadège, Gasilova, Natalia, Denoel, Thibaut, Schaefer, Niklaus, Prior, John O, Hagens, Gerrit, Lévy, Frédéric, Garrouste, Patrick, Segura, Jean-Manuel, Nyanguile, Origène

Volltext

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage von DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie

Volltext

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055 von Vendeville, Sandrine, Lin, Tse-I., Hu, Lili, Tahri, Abdellah, McGowan, David, Cummings, Maxwell D., Amssoms, Katie, Canard, Maxime, Last, Stefaan, Van den Steen, Iris, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre

Volltext

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties von Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre, Vendeville, Sandrine

Volltext

Bisphosphonate-Mediated Gene Vector Delivery from the Metal Surfaces of Stents von Fishbein, Ilia, Alferiev, Ivan S., Nyanguile, Origene, Gaster, Richard, Vohs, John M., Wong, Gordon S., Felderman, Howard, Chen, I-Wei, Choi, Hoon, Wilensky, Robert L., Levy, Robert J.

Volltext

Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors von Liang, Yuqiong, Ishida, Hisashi, Lenz, Oliver, Lin, Tse–I, Nyanguile, Origène, Simmen, Kenny, Pyles, Richard B, Bourne, Nigel, Yi, MinKyung, Li, Kui, Lemon, Stanley M

Volltext

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase von McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre

Volltext

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series von McGowan, David, Vendeville, Sandrine, Lin, Tse-I, Tahri, Abdellah, Hu, Lili, Cummings, Maxwell D., Amssoms, Katie, Berke, Jan Martin, Canard, Maxime, Cleiren, Erna, Dehertogh, Pascale, Last, Stefaan, Fransen, Els, Van Der Helm, Elisabeth, Van den Steen, Iris, Vijgen, Leen, Rouan, Marie-Claude, Fanning, Gregory, Nyanguile, Origène, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre

Volltext

Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase von Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Nyanguile, Origène, Simmen, Kenny, Van Remoortere, Pieter, Raboisson, Pierre, Vendeville, Sandrine

Volltext

Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase von Vandyck, Koen, Cummings, Maxwell D, Nyanguile, Origène, Boutton, Carlo W, Vendeville, Sandrine, McGowan, David, Devogelaere, Benoit, Amssoms, Katie, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Lory, Pedro, Hu, Lili, Beauchamp, Derek A, Simmen, Kenny, Raboisson, Pierre

Volltext

Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors von PAUWELS, Frederik, MOSTMANS, Wendy, SIMMEN, Kenneth A, QUIRYNEN, Ludo M. M, VAN DER HELM, Liesbet, BOUTTON, Carlo W, RUEFF, Anne-Stéphanie, CLEIREN, Erna, RABOISSON, Pierre, SURLERAUX, Dominique, NYANGUILE, Origène

Volltext

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus von NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver

Volltext

1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors von NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric

Volltext

Abstract 1304: AbYlinkTM: A site-selective labeling method for preclinical imaging of therapeutic antibodies von Postupalenko, Viktoriia, Marx, Léo, Viertl, David, Gasilova, Natalia, Plantin, Mathilde, Gsponer, Nadège, Johanssen, Alexandre, Denoel, Thibaut, Hagens, Gerrit, Segura, Jean-Manuel, Levy, Frédéric, Garrouste, Patrick, Prior, John, Schottelius, Margret, Schaefer, Niklaus, Nyanguile, Origene

Volltext

A Nonnatural Transcriptional Coactivator von Nyanguile, Origene, Uesugi, Motonari, Austin, David J., Verdine, Gregory L.

Volltext