Computational modeling of ERBB2-amplified breast cancer identifies combined ErbB2/3 blockade as superior to the combination of MEK and AKT inhibitors von Kirouac, Daniel C, Du, Jin Y, Lahdenranta, Johanna, Overland, Ryan, Yarar, Defne, Paragas, Violette, Pace, Emily, McDonagh, Charlotte F, Nielsen, Ulrik B, Onsum, Matthew D

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HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B von Kirouac, Daniel C, Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D, Nielsen, Ulrik B, Schoeberl, Birgit, McDonagh, Charlotte F

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Single-Cell Quantitative HER2 Measurement Identifies Heterogeneity and Distinct Subgroups within Traditionally Defined HER2-Positive Patients von Onsum, Matthew D, Geretti, Elena, Paragas, Violette, Kudla, Arthur J, Moulis, Sharon P, Luus, Lia, Wickham, Thomas J, McDonagh, Charlotte F, MacBeath, Gavin, Hendriks, Bart S

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Calling heads from tails: the role of mathematical modeling in understanding cell polarization von Onsum, Matthew D, Rao, Christopher V

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A mathematical model for neutrophil gradient sensing and polarization von Onsum, Matthew, Rao, Christopher V

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Numerical Computation of Diffusion on a Surface von Schwartz, Peter, Adalsteinsson, David, Colella, Phillip, Arkin, Adam Paul, Onsum, Matthew

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Response to Brentuximab Vedotin by CD30 Expression in Non-Hodgkin Lymphoma von Jagadeesh, Deepa, Horwitz, Steve, Bartlett, Nancy L, Kim, Youn, Jacobsen, Eric, Duvic, Madeleine, Little, Meredith, Trepicchio, William, Fenton, Keenan, Onsum, Matthew, Lisano, Julie, Advani, Ranjana

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Response to brentuximab vedotin versus physician’s choice by CD30 expression and large cell transformation status in patients with mycosis fungoides: An ALCANZA sub-analysis von Kim, Youn H., Prince, H. Miles, Whittaker, Sean, Horwitz, Steven M., Duvic, Madeleine, Bechter, Oliver, Sanches, Jose A., Stadler, Rudolf, Scarisbrick, Julia, Quaglino, Pietro, Zinzani, Pier Luigi, Wolter, Pascal, Eradat, Herbert, Pinter-Brown, Lauren C., Ortiz-Romero, Pablo L., Akilov, Oleg E., Trotman, Judith, Taylor, Kerry, Weichenthal, Michael, Walewski, Jan, Fisher, David, McNeeley, Marise, Gru, Alejandro A., Brown, Lisa, Palanca-Wessels, M. Corinna, Lisano, Julie, Onsum, Matthew, Bunn, Veronica, Little, Meredith, Trepicchio, William L., Dummer, Reinhard

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An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation von SCHOEBERL, Birgit, FABER, Anthony C, FULGHAM, Aaron, SONG, Youngchul, NIELSEN, Ulrik B, ENGELMAN, Jeffrey A, WONG, Kwok-Kin, DANAN LI, LIANG, Mei-Chih, CROSBY, Katherine, ONSUM, Matthew, BURENKOVA, Olga, PACE, Emily, WALTON, Zandra, LIN NIE

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Response to brentuximab vedotin by CD30 expression: Results from five trials in PTCL, CTCL, and B-cell lymphomas von Jagadeesh, Deepa, Horwitz, Steven M., Bartlett, Nancy L., Advani, Ranjana H., Jacobsen, Eric D., Duvic, Madeleine, Gautam, Ashish, Rao, Shangbang, Onsum, Matthew, Fanale, Michelle, Kim, Youn H.

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Response to brentuximab vedotin versus physician's choice by CD30 expression and large cell transformation status in patients with mycosis fungoides: An ALCANZA sub-analysis von Kim, Youn H, Prince, H. Miles, Whittaker, Sean, Horwitz, Steven M, Duvic, Madeleine, Bechter, Oliver, Sanches, Jose A, Stadler, Rudolf, Scarisbrick, Julia, Quaglino, Pietro, Zinzani, Pier Luigi, Wolter, Pascal, Eradat, Herbert, Pinter-Brown, Lauren C, Ortiz-Romero, Pablo L, Akilov, Oleg E, Trotman, Judith, Taylor, Kerry, Weichenthal, Michael, Walewski, Jan, Fisher, David, McNeeley, Marise, Gru, Alejandro A, Brown, Lisa, Palanca-Wessels, M. Corinna, Lisano, Julie, Onsum, Matthew, Bunn, Veronica, Little, Meredith, Trepicchio, William L, Dummer, Reinhard

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Autonomous Mobile Robot Control Based on White Blood Cell Chemotaxis von Onsum, Matthew D., Arkin, Adam P.

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Response to A+CHP by CD30 expression in the ECHELON-2 trial von Advani, Ranjana H., Horwitz, Steven M., Iyer, Swaminathan Padmanabhan, Bartlett, Nancy L., Kim, Won Seog, Tilly, Herve, Belada, David, Feldman, Tatyana, Illés, Árpád, Jacobsen, Eric D., Huettmann, Andreas, Zinzani, Pier Luigi, O'Connor, Owen A., Trepicchio, William L., Miao, Harry H., Rao, Shangbang, Onsum, Matthew, Manley, Thomas John, Illidge, Tim

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Abstract 233: Engineering Growth Factors For Cardiomyocyte Survival and Regeneration Following Ischemic Injury von Stowe, Timothy R, Eshghi, Shawdee, Jennings-Antipov, Laura D, Zhang, Yan, Gip, Phung, Onsum, Matthew D

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Potential regulators of HER2 activity in HER2-overexpressing gastric and gastroesophageal tumors: Analysis of HER3 and heregulin expression von Kudla, Arthur J., Paragas, Violette, Geretti, Elena, Onsum, Matthew D., McDonagh, Charlotte Fenton

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Abstract A10: In silico design of biomarker-optimized drug combinations in ERBB2+ cancers von Du, Jinyan, Kirouac, Daniel, Lahdenranta, Johanna, Overland, Ryan, Onsum, Matthew, McDonagh, Charlotte

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Abstract 413: Engineering Targeted Growth Factors for Selective Pro-survival Signaling in Apoptotic Cardiomyocytes Following Ischemic Injury von Stowe, Timothy R, Jennings-Antipov, Laura D, Kuchenbecker, Kristopher M, Zhang, Yan, Eshghi, Shawdee, Millard, Bjorn L, Nickerson, Andrea D, Nielsen, Ulrik B, Onsum, Matthew D

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Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification von Onsum, Matthew David, Wong, Kit, Herzmark, Paul, Bourne, Henry R, Arkin, Adam Paul

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323 Systemic administration of ladiratuzumab vedotin alone or in combination with pembrolizumab results in significant immune activation in the tumor microenvironment in metastatic... von Pusztai, Lajos, Lu, Hailing, Hale, Christopher, Grosse-Wilde, Anne, Specht, Jennifer, Modi, Shanu, Han, Hyo, Cortes, Javier, Oliveira, Mafalda, Garfin, Phillip, Wang, Zejing, Onsum, Matthew

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Preclinical activity of MM-111, a bispecific ErbB2/ErbB3 antibody in previously treated ErbB2-positive gastric and gastroesophageal junction cancer von Lahdenranta, Johanna, Paragas, Violette, Kudla, Arthur J., Overland, Ryan, Moyo, Victor M., Nielsen, Ulrik, McDonagh, Charlotte, Onsum, Matthew

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