Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys von Nagai, Yuji, Miyakawa, Naohisa, Takuwa, Hiroyuki, Hori, Yukiko, Oyama, Kei, Ji, Bin, Takahashi, Manami, Huang, Xi-Ping, Slocum, Samuel T., DiBerto, Jeffrey F., Xiong, Yan, Urushihata, Takuya, Hirabayashi, Toshiyuki, Fujimoto, Atsushi, Mimura, Koki, English, Justin G., Liu, Jing, Inoue, Ken-ichi, Kumata, Katsushi, Seki, Chie, Ono, Maiko, Shimojo, Masafumi, Zhang, Ming-Rong, Tomita, Yutaka, Nakahara, Jin, Suhara, Tetsuya, Takada, Masahiko, Higuchi, Makoto, Jin, Jian, Roth, Bryan L., Minamimoto, Takafumi

Volltext

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies von Tagai, Kenji, Ono, Maiko, Kubota, Manabu, Kitamura, Soichiro, Takahata, Keisuke, Seki, Chie, Takado, Yuhei, Shinotoh, Hitoshi, Sano, Yasunori, Yamamoto, Yasuharu, Matsuoka, Kiwamu, Takuwa, Hiroyuki, Shimojo, Masafumi, Takahashi, Manami, Kawamura, Kazunori, Kikuchi, Tatsuya, Okada, Maki, Akiyama, Haruhiko, Suzuki, Hisaomi, Onaya, Mitsumoto, Takeda, Takahiro, Arai, Kimihito, Arai, Nobutaka, Araki, Nobuyuki, Saito, Yuko, Trojanowski, John Q., Lee, Virginia M.Y., Mishra, Sushil K., Yamaguchi, Yoshiki, Kimura, Yasuyuki, Ichise, Masanori, Tomita, Yutaka, Zhang, Ming-Rong, Suhara, Tetsuya, Shigeta, Masahiro, Sahara, Naruhiko, Higuchi, Makoto, Shimada, Hitoshi

Volltext

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography von Vagenknecht, Patrick, Luzgin, Artur, Ono, Maiko, Ji, Bin, Higuchi, Makoto, Noain, Daniela, Maschio, Cinzia A., Sobek, Jens, Chen, Zhenyue, Konietzko, Uwe, Gerez, Juan A., Riek, Roland, Razansky, Daniel, Klohs, Jan, Nitsch, Roger M., Dean-Ben, Xose Luis, Ni, Ruiqing

Volltext

Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein von Ji, Bin, Ono, Maiko, Yamasaki, Tomoteru, Fujinaga, Masayuki, Zhang, Ming-Rong, Seki, Chie, Aoki, Ichio, Kito, Seiji, Sawada, Makoto, Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto

Volltext

MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice von Takado, Yuhei, Takuwa, Hiroyuki, Sampei, Kazuaki, Urushihata, Takuya, Takahashi, Manami, Shimojo, Masafumi, Uchida, Shoko, Nitta, Nobuhiro, Shibata, Sayaka, Nagashima, Keisuke, Ochi, Yoshihiro, Ono, Maiko, Maeda, Jun, Tomita, Yutaka, Sahara, Naruhiko, Near, Jamie, Aoki, Ichio, Shibata, Kazuhisa, Higuchi, Makoto

Volltext

Naïve liftings of DG modules von Nasseh, Saeed, Ono, Maiko, Yoshino, Yuji

Volltext

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls von Maruyama, Masahiro, Shimada, Hitoshi, Suhara, Tetsuya, Shinotoh, Hitoshi, Ji, Bin, Maeda, Jun, Zhang, Ming-Rong, Trojanowski, John Q., Lee, Virginia M.-Y., Ono, Maiko, Masamoto, Kazuto, Takano, Harumasa, Sahara, Naruhiko, Iwata, Nobuhisa, Okamura, Nobuyuki, Furumoto, Shozo, Kudo, Yukitsuka, Chang, Qing, Saido, Takaomi C., Takashima, Akihiko, Lewis, Jada, Jang, Ming-Kuei, Aoki, Ichio, Ito, Hiroshi, Higuchi, Makoto

Volltext

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies von Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W, Trojanowski, John Q, Lee, Virginia M-Y, Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, van Swieten, John C, Nordberg, Agneta, Suhara, Tetsuya, Zhang, Ming-Rong, Higuchi, Makoto

Volltext

Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model von Shimojo, Masafumi, Takuwa, Hiroyuki, Takado, Yuhei, Tokunaga, Masaki, Tsukamoto, Satoshi, Minatohara, Keiichiro, Ono, Maiko, Seki, Chie, Maeda, Jun, Urushihata, Takuya, Minamihisamatsu, Takeharu, Aoki, Ichio, Kawamura, Kazunori, Zhang, Ming-Rong, Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto

Volltext

Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy von Ono, Maiko, Komatsu, Masaaki, Ji, Bin, Takado, Yuhei, Shimojo, Masafumi, Minamihisamatsu, Takeharu, Warabi, Eiji, Yanagawa, Toru, Matsumoto, Gen, Aoki, Ichio, Kanaan, Nicholas M., Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto

Volltext

A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains von Shimojo, Masafumi, Ono, Maiko, Takuwa, Hiroyuki, Mimura, Koki, Nagai, Yuji, Fujinaga, Masayuki, Kikuchi, Tatsuya, Okada, Maki, Seki, Chie, Tokunaga, Masaki, Maeda, Jun, Takado, Yuhei, Takahashi, Manami, Minamihisamatsu, Takeharu, Zhang, Ming‐Rong, Tomita, Yutaka, Suzuki, Norihiro, Maximov, Anton, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Higuchi, Makoto

Volltext

Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models von Rui, Xiyan, Zhao, Xinran, Zhang, Nailian, Ding, Yuzhou, Seki, Chie, Ono, Maiko, Higuchi, Makoto, Zhang, Ming-Rong, Chu, Yong, Wei, Ruonan, Xu, Miaomiao, Cheng, Chao, Zuo, Changjing, Kimura, Yasuyuki, Ni, Ruiqing, Kai, Mototora, Tian, Mei, Yuan, Chunyan, Ji, Bin

Volltext

A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model von Kimura, Taeko, Ono, Maiko, Seki, Chie, Sampei, Kazuaki, Shimojo, Masafumi, Kawamura, Kazunori, Zhang, Ming-Rong, Sahara, Naruhiko, Takado, Yuhei, Higuchi, Makoto

Volltext

An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607) von Tagai, Kenji, Ikoma, Yoko, Endo, Hironobu, Debnath, Oiendrila Bhowmik, Seki, Chie, Matsuoka, Kiwamu, Matsumoto, Hideki, Oya, Masaki, Hirata, Kosei, Shinotoh, Hitoshi, Takahata, Keisuke, Kurose, Shin, Sano, Yasunori, Ono, Maiko, Shimada, Hitoshi, Kawamura, Kazunori, Zhang, Ming-Rong, Takado, Yuhei, Higuchi, Makoto

Volltext

A Machine Learning–Based Approach to Discrimination of Tauopathies Using [18F]PM‐PBB3 PET Images von Endo, Hironobu, Tagai, Kenji, Ono, Maiko, Ikoma, Yoko, Oyama, Asaka, Matsuoka, Kiwamu, Kokubo, Naomi, Hirata, Kosei, Sano, Yasunori, Oya, Masaki, Matsumoto, Hideki, Kurose, Shin, Seki, Chie, Shimizu, Hiroshi, Kakita, Akiyoshi, Takahata, Keisuke, Shinotoh, Hitoshi, Shimada, Hitoshi, Tokuda, Takahiko, Kawamura, Kazunori, Zhang, Ming‐Rong, Oishi, Kenichi, Mori, Susumu, Takado, Yuhei, Higuchi, Makoto

Volltext

PET-based classification of corticobasal syndrome von Nakano, Yoshikazu, Shimada, Hitoshi, Shinotoh, Hitoshi, Hirano, Shigeki, Tagai, Kenji, Sano, Yasunori, Yamamoto, Yasuharu, Endo, Hironobu, Matsuoka, Kiwamu, Takahata, Keisuke, Kubota, Manabu, Takado, Yuhei, Kimura, Yasuyuki, Ichise, Masanori, Ono, Maiko, Sahara, Naruhiko, Kawamura, Kazunori, Zhang, Ming-Rong, Kuwabara, Satoshi, Suhara, Tetsuya, Higuchi, Makoto

Volltext

Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy von Matsuoka, Kiwamu, Takado, Yuhei, Tagai, Kenji, Kubota, Manabu, Sano, Yasunori, Takahata, Keisuke, Ono, Maiko, Seki, Chie, Matsumoto, Hideki, Endo, Hironobu, Shinotoh, Hitoshi, Sahara, Yasuka, Obata, Takayuki, Near, Jamie, Kawamura, Kazunori, Zhang, Ming-Rong, Suhara, Tetsuya, Shimada, Hitoshi, Higuchi, Makoto

Volltext

Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor von Maeda, Jun, Minamihisamatsu, Takeharu, Shimojo, Masafumi, Zhou, Xiaoyun, Ono, Maiko, Matsuba, Yukio, Ji, Bin, Ishii, Hideki, Ogawa, Masanao, Akatsu, Hiroyasu, Kaneda, Daita, Hashizume, Yoshio, Robinson, John L, Lee, Virginia M -Y, Saito, Takashi, Saido, Takaomi C, Trojanowski, John Q, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto, Sahara, Naruhiko

Volltext

Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomograp... von Maeda, Jun, Ji, Bin, Irie, Toshiaki, Tomiyama, Takami, Maruyama, Masahiro, Okauchi, Takashi, Staufenbiel, Matthias, Iwata, Nobuhisa, Ono, Maiko, Saido, Takaomi C, Suzuki, Kazutoshi, Mori, Hiroshi, Higuchi, Makoto, Suhara, Tetsuya

Volltext

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula von Shinotoh, Hitoshi, Shimada, Hitoshi, Kokubo, Yasumasa, Tagai, Kenji, Niwa, Fumitoshi, Kitamura, Soichiro, Endo, Hironobu, Ono, Maiko, Kimura, Yasuyuki, Hirano, Shigeki, Mimuro, Maya, Ichise, Masanori, Sahara, Naruhiko, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto

Volltext