Molecular Mechanisms of Hypothalamic Insulin Resistance von Ono, Hiraku

Volltext

Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping? von Ono, Hiraku, Yokote, Koutaro

Volltext

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases von Yamamotoya, Takeshi, Hasei, Shun, Akasaka, Yasuyuki, Ohata, Yukino, Nakatsu, Yusuke, Kanna, Machi, Fujishiro, Midori, Sakoda, Hideyuki, Ono, Hiraku, Kushiyama, Akifumi, Misawa, Hidemi, Asano, Tomoichiro

Volltext

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis von Blouet, Clémence, Ono, Hiraku, Schwartz, Gary J.

Volltext

A Japanese Case of Familial Hypercholesterolemia with a Protein-truncating Variant in LDLR and a PCSK9 Variant without Significant Atherosclerosis but Showing Remarkable Achilles T... von Minamizuka, Takuya, Kobayashi, Junji, Tada, Hayato, Koshizaka, Masaya, Maezawa, Yoshiro, Ono, Hiraku, Yokote, Koutaro

Volltext

CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet von Kurita, Kenichi, Ishikawa, Ko, Takeda, Kenji, Fujimoto, Masanori, Ono, Hiraku, Kumagai, Jin, Inoue, Hiromi, Yokoh, Hidetaka, Yokote, Koutaro

Volltext

Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells von Nakatsu, Yusuke, Yamamotoya, Takeshi, Ueda, Koji, Ono, Hiraku, Inoue, Masa-Ki, Matsunaga, Yasuka, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Matsubara, Akio, Asano, Tomoichiro

Volltext

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis von Ono, Hiraku, Asano, Tomoichiro, Fujishiro, Midori, Inoue, Yuki, Ueda, Koji, Mori, Keiichi, Yamamotoya, Takeshi, Matsunaga, Yasuka, Nakatsu, Yusuke, Kushiyama, Akifumi, Sakoda, Hideyuki

Volltext

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic A... von Nakatsu, Yusuke, Kokubo, Hiroki, Bumdelger, Batmunkh, Yoshizumi, Masao, Yamamotoya, Takeshi, Matsunaga, Yasuka, Ueda, Koji, Inoue, Yuki, Inoue, Masa-Ki, Fujishiro, Midori, Kushiyama, Akifumi, Ono, Hiraku, Sakoda, Hideyuki, Asano, Tomoichiro

Volltext

Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines von Kanna, Machi, Nakatsu, Yusuke, Yamamotoya, Takeshi, Kushiyama, Akifumi, Fujishiro, Midori, Sakoda, Hideyuki, Ono, Hiraku, Arihiro, Koji, Asano, Tomoichiro

Volltext

The hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance von Ono, Hiraku

Volltext

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigen... von Akasaka, Yasuyuki, Hasei, Shun, Ohata, Yukino, Kanna, Machi, Nakatsu, Yusuke, Sakoda, Hideyuki, Fujishiro, Midori, Kushiyama, Akifumi, Ono, Hiraku, Matsubara, Akio, Hinata, Nobuyuki, Asano, Tomoichiro, Yamamotoya, Takeshi

Volltext

Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency – Effects of pemafibrate treatment von Minamizuka, Takuya, Kobayashi, Junji, Tada, Hayato, Miyashita, Kazuya, Koshizaka, Masaya, Maezawa, Yoshiro, Ono, Hiraku, Yokote, Koutaro

Volltext

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice von Mizuno, Yu, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ueda, Koji, Matsunaga, Yasuka, Inoue, Masa-Ki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kikuchi, Takako, Takahashi, Masahiro, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Asano, Tomoichiro, Kushiyama, Akifumi

Volltext

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons von LIN, Hua V, PLUM, Leona, ONO, Hiraku, GUTIERREZ-JUAREZ, Roger, SHANABROUGH, Marya, BOROK, Erzsebet, HORVATH, Tamas L, ROSSETTI, Luciano, ACCILI, Domenico

Volltext

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations von Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Yuki, Mori, Keiichi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro

Volltext

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats von Ono, Hiraku, Pocai, Alessandro, Wang, Yuhua, Sakoda, Hideyuki, Asano, Tomoichiro, Backer, Jonathan M, Schwartz, Gary J, Rossetti, Luciano

Volltext

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice von Inoue, Masa-Ki, Matsunaga, Yasuka, Nakatsu, Yusuke, Yamamotoya, Takeshi, Ueda, Koji, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Iwashita, Misaki, Sano, Tomomi, Nishimura, Fusanori, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Asano, Tomoichiro

Volltext

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation von Ueda, Koji, Nakatsu, Yusuke, Yamamotoya, Takeshi, Ono, Hiraku, Inoue, Yuki, Inoue, Masa-Ki, Mizuno, Yu, Matsunaga, Yasuka, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Takahashi, Shin-Ichiro, Matsubara, Akio, Asano, Tomoichiro

Volltext

Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16 von Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Masa-ki, Mizuno, Yu, Nakanishi, Mikako, Sano, Tomomi, Yamawaki, Yosuke, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Ryo, Akihide, Ono, Hiraku, Minamino, Tohru, Takahashi, Shin-Ichiro, Ohno, Haruya, Yoneda, Masayasu, Takahashi, Kei, Ishihara, Hisamitsu, Katagiri, Hideki, Nishimura, Fusanori, Kanematsu, Takashi, Yamada, Tetsuya, Asano, Tomoichiro

Volltext