Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models von LOBELL, Robert B, OMER, Charles A, KRAL, Astrid M, DONGMING LIU, LUMMA, William C, MACHOTKA, Samuel V, RANDS, Elaine, WILLIAMS, Theresa M, GRAHAM, Samuel L, HARTMAN, George D, OLIFF, Allen I, HEIMBROOK, David C, ABRAMS, Marc T, KOHL, Nancy E, BHIMNATHWALA, Hema G, BRUCKER, Mary Jo, BUSER, Carolyn A, DAVIDE, Joseph P, DESOLMS, S. Jane, DINSMORE, Christopher J, ELLIS-HUTCHINGS, Michelle S

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Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry von Omer, C. A., Gibbs, J. B.

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Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor von OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T

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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I von ZHANG, F. L, DIEHL, R. E, KOHL, N. E, GIBBS, J. B, GIROS, B, CASEY, P. J, OMER, C. A

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Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferase... von Omer, Charles A, Kral, Astrid M, Diehl, Ronald E, Prendergast, George C, Powers, Scott, Allen, Charles M, Gibbs, Jackson B, Kohl, Nancy E

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Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus von Omer, C.A. (E.I. Du Pont Co., Willimgton, DE), Lenstra, R, Litle, P.J, Dean, C, Tepperman, J.M, Leto, K.J, Romesser, J.A, O'Keefe, D.P

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway von Pompliano, David L, Schaber, Michael D, Mosser, Scott D, Omer, Charles A, Shafer, Jules A, Gibbs, Jackson B

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice von Kohl, Nancy E, Omer, Charles A, Conner, Michael W, Anthony, Neville J, Davide, Joseph P, Desolms, S. Jane, Giuliani, Elizabeth A, Gomez, Robert P, Graham, Samuel L, Hamilton, Kelly, Handt, Laurence K, Hartman, George D, Koblan, Kenneth S, Kral, Astrid M, Miller, Patricia J, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Gibbs, Jackson B, Oliff, Allen

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Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat von RESNICK, R, OMER, C. A, FARAS, A. J

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis von Barrington, Rebecca E., Subler, Mark A., Rands, Elaine, Omer, Charles A., Miller, Patricia J., Hundley, Jeffrey E., Koester, Steven K., Troyer, Dean A., Bearss, David J., Conner, Michael W., Gibbs, Jackson B., Hamilton, Kelly, Koblan, Kenneth S., Mosser, Scott D., O'Neill, Timothy J., Schaber, Michael D., Senderak, Edith T., Windle, Jolene J., Oliff, Allen, Kohl, Nancy E.

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NMR studies of novel inhibitors bound to farnesyl‐protein transferase von Koblan, Kenneth S., Mosser, Scott D., Omer, Charles A., Christopher Culberson, J., Jane Desolms, S., Giuliani, Elizabeth A., Pitzenberger, Steven M., Bogusky, Michael J.

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Farnesyltransferase inhibitors and anti-Ras therapy von GIBBS, J. B, KOHL, N. E, GRAHAM, S. L, HARTMAN, G. D, OLIFF, A, KOBLAN, K. S, OMER, C. A, SEPP-LORENZINO, L, ROSEN, N, ANTHONY, N. J, CONNER, M. W, DESOLMS, S. J, WILLIAMS, T. M

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Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element of Streptomyces coelicolor von Omer, C.A, Cohen, S.N

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Site-specific insertion of biologically functional adventitious genes into the Streptomyces lividans chromosome von OMER, C. A, STEIN, D, COHEN, S. N

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Identification of Tcf4 Residues Involved in High-Affinity β-Catenin Binding von Omer, Charles A., Miller, Patricia J., Diehl, Ronald E., Kral, Astrid M.

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Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhib... von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M

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Analysis of recombination occurring at SLP1 att sites von LEE, S. C, OMER, C. A, BRASCH, M. A, COHEN, S. N

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Farnesyltransferase inhibitors versus Ras inhibitors von Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Koblan, Kenneth S, Kohl, Nancy E, Omer, Charles A, Oliff, Allen

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Phenobarbital and sulfonylurea-inducible operons encoding herbicide metabolizing cytochromes P-450 in Streptomyces griseolus von Patel, Nina V., Omer, Charles A.

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Evidence for involvement of an RNA primer in initiation of strong-stop plus DNA synthesis during reverse transcription in vitro von OMER, C. A, RESNICK, R, FARAS, A. J

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