The PD-L1/4-1BB Bispecific Antibody-Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner von Peper-Gabriel, Janet K, Pavlidou, Marina, Pattarini, Lucia, Morales-Kastresana, Aizea, Jaquin, Thomas J, Gallou, Catherine, Hansbauer, Eva-Maria, Richter, Marleen, Lelievre, Helene, Scholer-Dahirel, Alix, Bossenmaier, Birgit, Sancerne, Celine, Riviere, Matthieu, Grandclaudon, Maximilien, Zettl, Markus, Bel Aiba, Rachida S, Rothe, Christine, Blanc, Veronique, Olwill, Shane A

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Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma von Matschiner, Gabriele, Fitzgerald, Mary F., Moebius, Ulrich, Hohlbaum, Andreas M., Gille, Hendrik, Jensen, Kristian, Kirchfeld, Klaus, Rattenstetter, Barbara, Laforge, Alice, Bel Aiba, Rachida S., Ciccotosto, Joe, Nyugen, Hong, Foster, Martyn L., Snouwaert, John N., Nguyen, MyTrang, Koller, Beverly H., Matis, Louis, Anderson, Gary P., Olwill, Shane A.

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Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF von Ward, Claire, Kuehn, Diana, Burden, Roberta E, Gormley, Julie A, Jaquin, Thomas J, Gazdoiu, Mihaela, Small, Donna, Bicknell, Roy, Johnston, James A, Scott, Christopher J, Olwill, Shane A

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Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey von Hohlbaum, Andreas M, Gille, Hendrik, Trentmann, Stefan, Kolodziejczyk, Maria, Rattenstetter, Barbara, Laarakkers, Coby M, Katzmann, Galina, Christian, Hans Jürgen, Andersen, Nicole, Allersdorfer, Andrea, Olwill, Shane A, Meibohm, Bernd, Audoly, Laurent P, Swinkels, Dorine W, Swelm, Rachel P L

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Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells von McCarron, Paul A, Marouf, Waleed M, Quinn, Derek J, Fay, Francois, Burden, Roberta E, Olwill, Shane A, Scott, Christopher J

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Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis von BURDEN, Roberta E, GORMLEY, Julie A, SCOTT, Christopher J, JAQUIN, Thomas J, SMALL, Donna M, QUINN, Derek J, HEGARTY, Shauna M, WARD, Claire, WALKER, Brian, JOHNSTON, James A, OLWILL, Shane A

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A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity von Olwill, Shane A, Joffroy, Christian, Gille, Hendrik, Vigna, Elisa, Matschiner, Gabriele, Allersdorfer, Andrea, Lunde, Bradley M, Jaworski, Jakub, Burrows, James F, Chiriaco, Cristina, Christian, Hans Jürgen, Hülsmeyer, Martin, Trentmann, Stefan, Jensen, Kristian, Hohlbaum, Andreas M, Audoly, Laurent

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Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas von Burden, Roberta E., Gormley, Julie A., Kuehn, Diana, Ward, Claire, Kwok, Hang Fai, Gazdoiu, Mihaela, McClurg, Angela, Jaquin, Thomas J., Johnston, James A., Scott, Christopher J., Olwill, Shane A.

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Multiplex Immunoassay for Serological Diagnosis of Mycobacterium bovis Infection in Cattle von Whelan, Clare, Shuralev, Eduard, O'Keeffe, Grainne, Hyland, Paula, Kwok, Hang Fai, Snoddy, Philip, O'Brien, Amanda, Connolly, Marie, Quinn, Padraig, Groll, Matt, Watterson, Todd, Call, Sara, Kenny, Kevin, Duignan, Anthony, Hamilton, Mary Jo, Buddle, Bryce M., Johnston, James A., Davis, William C., Olwill, Shane A., Clarke, John

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Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity von Kwok, Hang Fai, Buick, Richard J, Kuehn, Diana, Gormley, Julie A, Doherty, Declan, Jaquin, Thomas J, McClurg, Angela, Ward, Claire, Byrne, Teresa, Jaworski, Jacob, Leung, Ka Lai, Snoddy, Philip, McAnally, Christine, Burden, Roberta E, Gray, Breena, Lowry, Jenny, Sermadiras, Isabelle, Gruszka, Natalia, Courtenay-Luck, Nigel, Kissenpfennig, Adrien, Scott, Christopher J, Johnston, James A, Olwill, Shane A

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Application of the Enfer chemiluminescent multiplex ELISA system for the detection of Mycobacterium bovis infection in goats von Shuralev, Eduard, Quinn, Padraig, Doyle, Mairead, Duignan, Anthony, Kwok, Hang Fai, Bezos, Javier, Olwill, Shane A., Gormley, Eamonn, Aranaz, Alicia, Good, Margaret, Davis, William C., Clarke, John, Whelan, Clare

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New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016 von Adusumilli, Prasad S, Cha, Edward, Cornfeld, Mark, Davis, Thomas, Diab, Adi, Dubensky, Thomas W, Evans, Elizabeth, Grogan, Jane L, Irving, Bryan A, Leidner, Rom S, Olwill, Shane A, Soon-Shiong, Patrick, Triebel, Frederic, Tuck, David, Bot, Adrian, Dansey, Roger D, Drake, Charles G, Freeman, Gordon J, Ibrahim, Ramy, Patel, Salil, Chen, Daniel S

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Tumor-localized costimulatory T cell engagement by the 4-1BB/HER2 bispecific antibody-Anticalin fusion PRS-343 von Hinner, Marlon J, Bel Aiba, Rachida Siham, Jaquin, Thomas J, Berger, Sven, Dürr, Manuela Carola, Schlosser, Corinna, Allersdorfer, Andrea, Wiedenmann, Alexander, Matschiner, Gabriele, Schüler, Julia, Moebius, Ulrich, Rothe, Christine, Matis, Louis, Olwill, Shane Anthony

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Stable expression and purification of a functional processed Fab′ fragment from a single nascent polypeptide in CHO cells expressing the mCAT-1 retroviral receptor von Camper, Nicolas, Byrne, Teresa, Burden, Roberta E., Lowry, Jenny, Gray, Breena, Johnston, James A., Migaud, Marie E., Olwill, Shane A., Buick, Richard J., Scott, Christopher J.

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All‐trans retinoic acid‐induced downregulation of annexin II expression in myeloid leukaemia cell lines is not confined to acute promyelocytic leukaemia von Olwill, Shane A., McGlynn, Hugh, Gilmore, William S., Alexander, H. D.

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Expression and purification of diagnostically sensitive mycobacterial ( Mycobacterium bovis) antigens and profiling of their humoral immune response in a rabbit model von Kwok, Hang Fai, Scott, Christopher J., Snoddy, Philip, Buick, Richard J., Johnston, James A., Olwill, Shane A.

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Annexin II cell surface and mRNA expression in human acute myeloid leukaemia cell lines von Olwill, Shane A., McGlynn, Hugh, Gilmore, William S., Denis Alexander, H.

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Abstract 3268: Costimulatory T-cell engagement by PRS-342, a GPC3/4-1BB bispecific molecule, leads to activation of T-cells and tumor growth inhibition in a HCC humanized mouse mod... von Bossenmaier, Birgit, Schlosser, Corinna, Aiba, Rachida Siham Bel, Barthels, Christian, Weiche, Benjamin, Eichner, Timo, Yegres, Michelle, Olwill, Shane A.

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Antibody Conjugates and Therapeutic Strategies von McCarron, Paul A, Olwill, Shane A, Marouf, Waleed M Y, Buick, Richard J, Walker, Brian, Scott, Christopher J

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Abstract LB135: Simultaneous costimulatory T-cell engagement and checkpoint inhibition by PRS-344/S095012, a PD-L1/4-1BB bispecific compound for tumor localized activation of the i... von Morales-Kastresana, Aizea, Pavlidou, Marina, Peper, Janet, Pattarini, Lucia, Barthels, Christian, Hansbauer, Eva-Maria, Aiba, Rachida Bel, Bossenmaier, Birgit, Scholer-Dahirel, Alix, Jaquin, Thomas, Gallou, Catherine, Blanc, Véronique, Rothe, Christine, Olwill, Shane

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