Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size von Easton, Rachael M., Cho, Han, Roovers, Kristin, Shineman, Diana W., Mizrahi, Moshe, Forman, Mark S., Lee, Virginia M.-Y., Szabolcs, Matthias, de Jong, Ron, Oltersdorf, Tilman, Ludwig, Thomas, Efstratiadis, Argiris, Birnbaum, Morris J.

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer von Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

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Solution Structure of the Antiapoptotic Protein bcl-2 von Petros, Andrew M., Medek, Ales, Nettesheim, David G., Kim, Daniel H., Yoon, Ho Sup, Swift, Kerry, Matayoshi, Edmund D., Oltersdorf, Tilman, Fesik, Stephen W.

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Trial of Solanezumab in Preclinical Alzheimer’s Disease von Sperling, Reisa A., Donohue, Michael C., Raman, Rema, Rafii, Michael S., Johnson, Keith, Masters, Colin L., van Dyck, Christopher H., Iwatsubo, Takeshi, Marshall, Gad A., Yaari, Roy, Mancini, Michele, Holdridge, Karen C., Case, Michael, Sims, John R., Aisen, Paul S.

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Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers von Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Luo, Yan, Liu, Xuesong, Shi, Yan, Guan, Ran, Magnone, Shayna R., Klinghofer, Vered, Johnson, Eric F., Bouska, Jennifer, Shoemaker, Alexander, Oleksijew, Anatol, Jarvis, Ken, Park, Chang, Jong, Ron De, Oltersdorf, Tilman, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.

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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment... von Li, Qun, Woods, Keith W., Thomas, Sheela, Zhu, Gui-Dong, Packard, Garrick, Fisher, John, Li, Tongmei, Gong, Jianchun, Dinges, Jurgen, Song, Xiaohong, Abrams, Jason, Luo, Yan, Johnson, Eric F., Shi, Yan, Liu, Xuesong, Klinghofer, Vered, Des Jong, Ron, Oltersdorf, Tilman, Stoll, Vincent S., Jakob, Clarissa G., Rosenberg, Saul H., Giranda, Vincent L.

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A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members von Diaz, J L, Oltersdorf, T, Horne, W, McConnell, M, Wilson, G, Weeks, S, Garcia, T, Fritz, L C

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Memantine and Cholinesterase Inhibitor Use in Alzheimer Disease Trials: Potential for Confounding by Indication (P6.178) von Huisa, Branko, Thomas, Ronald, Jin, Shelia, Oltersdorf, Tilman, Taylor, Curtis, Feldman, Howard

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours von Oltersdorf, Tilman, Elmore, Steven W., Shoemaker, Alexander R., Armstrong, Robert C., Augeri, David J., Belli, Barbara A., Bruncko, Milan, Deckwerth, Thomas L., Dinges, Jurgen, Hajduk, Philip J., Joseph, Mary K., Kitada, Shinichi, Korsmeyer, Stanley J., Kunzer, Aaron R., Letai, Anthony, Li, Chi, Mitten, Michael J., Nettesheim, David G., Ng, ShiChung, Nimmer, Paul M., O'Connor, Jacqueline M., Oleksijew, Anatol, Petros, Andrew M., Reed, John C., Shen, Wang, Tahir, Stephen K., Thompson, Craig B., Tomaselli, Kevin J., Wang, Baole, Wendt, Michael D., Zhang, Haichao, Fesik, Stephen W., Rosenberg, Saul H.

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Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial von Schneider, Lon S, Thomas, Ronald G, Hendrix, Suzanne, Rissman, Robert A, Brewer, James B, Salmon, David P, Oltersdorf, Tilman, Okuda, Tomohiro, Feldman, Howard H

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Rapamycin Inhibits Akt-Mediated Oncogenic Transformation and Tumor Growth von Liu, Xuesong, Powlas, Jessica, Shi, Yan, Oleksijew, Anatol X, Shoemaker, Alexander R, De Jong, Ron, Oltersdorf, Tilman, Giranda, Vincent L, Luo, Yan

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Oral IDN‐6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C von Pockros, Paul J., Schiff, Eugene R., Shiffman, Mitchell L., McHutchison, John G., Gish, Robert G., Afdhal, Nezam H., Makhviladze, Manana, Huyghe, Mira, Hecht, David, Oltersdorf, Tilman, Shapiro, David A.

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IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs von TAMM, I, YAN WANG, SAUSVILLE, E, SCUDIERO, D. A, VIGNA, N, OLTERSDORF, T, REED, J. C

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A phase I, first-in-human, dose escalation study of intravenous TK216 in patients with relapsed or refractory Ewing sarcoma von Federman, Noah, Meyers, Paul A., Daw, Najat C., Toretsky, Jeffrey, Breitmeyer, James Bradley, Singh, Arun S., Miller, Langdon L., Oltersdorf, Tilman, Jezior, Deborah, Jessen, Katayoun A., Lannutti, Brian, Ludwig, Joseph A.

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo von Luo, Yan, Shoemaker, Alexander R, Liu, Xuesong, Woods, Keith W, Thomas, Sheela A, de Jong, Ron, Han, Edward K, Li, Tongmei, Stoll, Vincent S, Powlas, Jessica A, Oleksijew, Anatol, Mitten, Michael J, Shi, Yan, Guan, Ran, McGonigal, Thomas P, Klinghofer, Vered, Johnson, Eric F, Leverson, Joel D, Bouska, Jennifer J, Mamo, Mulugeta, Smith, Richard A, Gramling-Evans, Emily E, Zinker, Bradley A, Mika, Amanda K, Nguyen, Phong T, Oltersdorf, Tilman, Rosenberg, Saul H, Li, Qun, Giranda, Vincent L

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Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2) von Lovenberg, Timothy W., Crowe, Paul D., Liu, Changlu, Chalmers, Derek T., Liu, Xin-Jun, Liaw, Chen, Clevenger, William, Oltersdorf, Tilman, De Souza, Errol B., Maki, Richard A.

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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo von SHOEMAKER, Alex R, OLEKSIJEW, Anatol, MARSH, Kennan, MCCLELLAN, William, NELLANS, Hugh, NG, Shichung, NIMMER, Paul, O'CONNOR, Jacqueline M, OLTERSDORF, Tilman, WEIGUO QING, WANG SHEN, STAVROPOULOS, Jason, BAUCH, Joy, TAHIR, Stephen K, BAOLE WANG, WARNER, Robert, HAICHAO ZHANG, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, BELLI, Barbara A, BORRE, Tony, BRUNCKO, Milan, DECKWIRTH, Thomas, FROST, David J, JARVIS, Ken, JOSEPH, Mary K

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo von Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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SAT-429 Final Results from the First in Man Phase 1 Clinical Trial of CRN00808, an Orally Bioavailable sst2-Selective, Nonpeptide Somatostatin Biased Agonist, for the Treatment of... von Madan, Ajay, Zhu, Yun Fei, Markison, Stacy, Betz, Stephen, Krasner, Alan, Luo, Rosa, Oltersdorf, Tilman, Jochelson, Theresa, Lickliter, Jason, Struthers, Scott

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Structural and Functional Complementation of an Inactive Bcl-2 Mutant by Bax Truncation von Ottilie, Sabine, Diaz, Jose-Luis, Chang, Julia, Wilson, Gary, Tuffo, K. Michelle, Weeks, Suzanne, McConnell, Michael, Wang, Yan, Oltersdorf, Tilman, Fritz, Lawrence C.

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