Application of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles von Mosallanejad, Arash, Lorthioir, Olivier

Volltext

Blue light enabled access to novel (hetero)aromatic bridged pyrrolidine alcohols von Lorthioir, Olivier, Demanze, Sylvain, Nassoy, Anne-Chloé

Volltext

Merging nucleophilic phosphine catalysis and photocatalysis for the rapid assembly of 2-oxabicyclo-2.1.1hexane scaffolds from feedstock allyl alcohols von Whalley, David M, Carlino, Luca, Putra, Okky Dwichandra, Anderson, Niall A, Coote, Susannah C, Lorthioir, Olivier

Volltext

An efficient and flexible route to novel triazolopiperazine scaffolds von Lorthioir, Olivier, Greenwood, Ryan D., Lister, Andrew, Tucker, Michael J.

Volltext

The identification of novel orally active mGluR5 antagonist GSK2210875 von Pilla, Maria, Andreoli, Michela, Tessari, Michela, Delle-Fratte, Sonia, Roth, Adelheid, Butler, Sharon, Brown, Fiona, Shah, Parita, Bettini, Ezio, Cavallini, Palmina, Benedetti, Roberto, Minick, Doug, Smith, Paul, Tehan, Ben, D’Alessandro, Pier, Lorthioir, Olivier, Ball, Catherine, Garzya, Vincenzo, Goodacre, Caroline, Watson, Stephen

Volltext

Multiple Charged and Aromatic Residues in CCR5 Amino-terminal Domain Are Involved in High Affinity Binding of Both Chemokines and HIV-1 Env Protein von Blanpain, C, Doranz, B J, Vakili, J, Rucker, J, Govaerts, C, Baik, S S, Lorthioir, O, Migeotte, I, Libert, F, Baleux, F, Vassart, G, Doms, R W, Parmentier, M

Volltext

Transfer of photochemistry from UV to visible: An expedient access to a bridged pyrrolidine von Lorthioir, Olivier, Corner, Thomas, Demanze, Sylvain, Greenwood, Ryan, Proctor, Katie, Stokes, Stephen, Turner, Paul

Volltext

Merging nucleophilic phosphine catalysis and photocatalysis for the rapid assembly of 2-oxabicyclo-[2.1.1]hexane scaffolds from feedstock allyl alcohols von Whalley, David M, Carlino, Luca, Putra, Okky Dwichandra, Anderson, Niall A, Coote, Susannah C, Lorthioir, Olivier

Volltext

Access to 2-Oxabicyclo2.1.1hexanes and their use in Scaffold Hopping von Lorthioir, Olivier, Anderson, Niall, Boyd, Scott, Carlino, Luca, Davey, Paul, Hodds, William, Howard, Megan, Lindhagen, Marika, Proctor, Katie, Putra, Okky Dwichandra, Smith, Theo, Turner, Oliver, Woodhouse, Alfie, Woodward, Millie

Volltext

Access to 2‑Oxabicyclo[2.1.1]hexanes and their use in Scaffold Hopping von Lorthioir, Olivier, Anderson, Niall, Boyd, Scott, Carlino, Luca, Davey, Paul, Hodds, William, Howard, Megan, Lindhagen, Marika, Proctor, Katie, Putra, Okky Dwichandra, Smith, Theo, Turner, Oliver, Woodhouse, Alfie, Woodward, Millie

Volltext

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure von HOLMES, Ian P, BLUNT, Richard J, HOWES, Claire M, MICHELI, Fabrizio, DI FABIO, Romano, DONATI, Daniele, TERRENI, Silvia, HAMPRECHT, Dieter, ARISTA, Luca, WORBY, Angela, WATSON, Steve P, LORTHIOIR, Olivier E, BLOWERS, Stephen M, GRIBBLE, Andy, PAYNE, Andrew H, STANSFIELD, Ian G, WOOD, Martyn, WOOLLARD, Patrick M, REAVILL, Charlie

Volltext

Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors von Petrović, Dušan, Scott, James S., Bodnarchuk, Michael S., Lorthioir, Olivier, Boyd, Scott, Hughes, George M., Lane, Jordan, Wu, Allan, Hargreaves, David, Robinson, James, Sadowski, Jens

Volltext

Optimization of Potent, Efficacious, Selective and Blood–Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations von Thomson, Clare, Braybrooke, Erin, Colclough, Nicola, Davies, Nichola L., Floc’h, Nicolas, Greenwood, Ryan, Guérot, Carine, Hargreaves, David, Johnstrom, Peter, Khurana, Puneet, Kostomiris, Demetrios H., Li, Songlei, Lister, Andrew, Lorthioir, Olivier, Martin, Scott, McCoull, William, McLean, Neville J., McWilliams, Lisa, Orme, Jonathan P., Packer, Martin J., Pearson, Stuart, Swaih, Aisha M., Tentarelli, Sharon, Tucker, Michael J., Ward, Richard A., Wilkinson, Stephen, Winlow, Poppy, Wood, Isabel L.

Volltext

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance von Finlay, M. Raymond V, Barton, Peter, Bickerton, Sue, Bista, Michal, Colclough, Nicola, Cross, Darren A. E, Evans, Laura, Floc’h, Nicolas, Gregson, Clare, Guérot, Carine M, Hargreaves, David, Kang, Xiaoming, Lenz, Eva M, Li, Xu, Liu, Yi, Lorthioir, Olivier, Martin, Matthew J, McKerrecher, Darren, McWhirter, Claire, O’Neill, Daniel, Orme, Jonathan P, Mosallanejad, Arash, Rahi, Amar, Smith, Paul D, Talbot, Verity, Ward, Richard A, Wrigley, Gail, Wylot, Marta, Xue, Lin, Yao, Tieguang, Ye, Yang, Zhao, Xiliang

Volltext

Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors von Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Gingipalli, Lakshmaiah, Ikeda, Timothy, Johnson, Tony, Kawatkar, Sameer, Lorthioir, Olivier, Pike, Andy, Pollard, Hannah, Read, Jon, Su, Qibin, Wang, Haiyun, Wang, Huimin, Wang, Lianghe, Wang, Peng, Edmondson, Scott D.

Volltext

Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors von Grimster, Neil P., Gingipalli, Lakshmaiah, Balazs, Amber, Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Goldberg, Frederick W., Ikeda, Tim, Johnson, Tony, Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Lorthioir, Olivier, Mfuh, Adelphe, Patel, Joe, Pike, Andy, Read, Jon, Romero, Romulo, Sarkar, Ujjal, Sha, Li, Simpson, Iain, Song, Kun, Su, Qibin, Wang, Haixia, Watson, David, Wu, Allan, Zehnder, Troy E., Zheng, XiaoLan, Li, Shaolu, Dong, Zhiqiang, Yang, Dejian, Song, Yanwei, Wang, Peng, Liu, Xuemei, Dowling, James E., Edmondson, Scott D.

Volltext

5-HT 7 Receptor Antagonists with an Unprecedented Selectivity Profile von Ates, Ali, Burssens, Pierre, Lorthioir, Olivier, Lo Brutto, Patrick, Dehon, Gwenael, Keyaerts, Jean, Coloretti, Francis, Lallemand, Bénédicte, Verbois, Valérie, Gillard, Michel, Vermeiren, Céline

Volltext

5‐HT7 Receptor Antagonists with an Unprecedented Selectivity Profile von Ates, Ali, Burssens, Pierre, Lorthioir, Olivier, Lo Brutto, Patrick, Dehon, Gwenael, Keyaerts, Jean, Coloretti, Francis, Lallemand, Bénédicte, Verbois, Valérie, Gillard, Michel, Vermeiren, Céline

Volltext

Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease von Koshibu, Kyoko, van Asperen, Judith, Gerets, Helga, Garcia-Ladona, Javier, Lorthioir, Olivier, Courade, Jean-Phillippe

Volltext

Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine von Amara, Ali, Lorthioir, Olivier, Valenzuela, Agustin, Magerus, Aude, Thelen, Marcus, Montes, Monica, Virelizier, Jean-Louis, Delepierre, Muriel, Baleux, Françoise, Lortat-Jacob, Hugues, Arenzana-Seisdedos, Fernando

Volltext