MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate von Ireland, Abbie S., Micinski, Alexi M., Kastner, David W., Guo, Bingqian, Wait, Sarah J., Spainhower, Kyle B., Conley, Christopher C., Chen, Opal S., Guthrie, Matthew R., Soltero, Danny, Qiao, Yi, Huang, Xiaomeng, Tarapcsák, Szabolcs, Devarakonda, Siddhartha, Chalishazar, Milind D., Gertz, Jason, Moser, Justin C., Marth, Gabor, Puri, Sonam, Witt, Benjamin L., Spike, Benjamin T., Oliver, Trudy G.

Volltext

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion von Chalishazar, Milind D, Wait, Sarah J, Huang, Fang, Ireland, Abbie S, Mukhopadhyay, Anandaroop, Lee, Younjee, Schuman, Sophia S, Guthrie, Matthew R, Berrett, Kristofer C, Vahrenkamp, Jeffery M, Hu, Zeping, Kudla, Marek, Modzelewska, Katarzyna, Wang, Guoying, Ingolia, Nicholas T, Gertz, Jason, Lum, David H, Cosulich, Sabina C, Bomalaski, John S, DeBerardinis, Ralph J, Oliver, Trudy G

Volltext

The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment von Mollaoglu, Gurkan, Jones, Alex, Wait, Sarah J., Mukhopadhyay, Anandaroop, Jeong, Sangmin, Arya, Rahul, Camolotto, Soledad A., Mosbruger, Timothy L., Stubben, Chris J., Conley, Christopher J., Bhutkar, Arjun, Vahrenkamp, Jeffery M., Berrett, Kristofer C., Cessna, Melissa H., Lane, Thomas E., Witt, Benjamin L., Salama, Mohamed E., Gertz, Jason, Jones, Kevin B., Snyder, Eric L., Oliver, Trudy G.

Volltext

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer von Wagner, Alex H., Devarakonda, Siddhartha, Skidmore, Zachary L., Krysiak, Kilannin, Ramu, Avinash, Trani, Lee, Kunisaki, Jason, Masood, Ashiq, Waqar, Saiama N., Spies, Nicholas C., Morgensztern, Daniel, Waligorski, Jason, Ponce, Jennifer, Fulton, Robert S., Maggi, Leonard B., Weber, Jason D., Watson, Mark A., O’Conor, Christopher J., Ritter, Jon H., Olsen, Rachelle R., Cheng, Haixia, Mukhopadhyay, Anandaroop, Can, Ismail, Cessna, Melissa H., Oliver, Trudy G., Mardis, Elaine R., Wilson, Richard K., Griffith, Malachi, Griffith, Obi L., Govindan, Ramaswamy

Volltext

Family matters: How MYC family oncogenes impact small cell lung cancer von Brägelmann, Johannes, Böhm, Stefanie, Guthrie, Matthew R., Mollaoglu, Gurkan, Oliver, Trudy G., Sos, Martin L.

Volltext

ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer von Olsen, Rachelle R., Ireland, Abbie S., Kastner, David W., Groves, Sarah M., Spainhower, Kyle B., Pozo, Karine, Kelenis, Demetra P., Whitney, Christopher P., Guthrie, Matthew R., Wait, Sarah J., Soltero, Danny, Witt, Benjamin L., Quaranta, Vito, Johnson, Jane E., Oliver, Trudy G.

Volltext

A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest von Tsabar, Michael, Mock, Caroline S., Venkatachalam, Veena, Reyes, Jose, Karhohs, Kyle W., Oliver, Trudy G., Regev, Aviv, Jambhekar, Ashwini, Lahav, Galit

Volltext

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer von Dammert, Marcel A., Brägelmann, Johannes, Olsen, Rachelle R., Böhm, Stefanie, Monhasery, Niloufar, Whitney, Christopher P., Chalishazar, Milind D., Tumbrink, Hannah L., Guthrie, Matthew R., Klein, Sebastian, Ireland, Abbie S., Ryan, Jeremy, Schmitt, Anna, Marx, Annika, Ozretić, Luka, Castiglione, Roberta, Lorenz, Carina, Jachimowicz, Ron D., Wolf, Elmar, Thomas, Roman K., Poirier, John T., Büttner, Reinhard, Sen, Triparna, Byers, Lauren A., Reinhardt, H. Christian, Letai, Anthony, Oliver, Trudy G., Sos, Martin L.

Volltext

Sox2 Cooperates with Lkb1 Loss in a Mouse Model of Squamous Cell Lung Cancer von Mukhopadhyay, Anandaroop, Berrett, Kristofer C., Kc, Ushma, Clair, Phillip M., Pop, Stelian M., Carr, Shamus R., Witt, Benjamin L., Oliver, Trudy G.

Volltext

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop von Oliver, Trudy G., Meylan, Etienne, Chang, Gregory P., Xue, Wen, Burke, James R., Humpton, Timothy J., Hubbard, Diana, Bhutkar, Arjun, Jacks, Tyler

Volltext

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer von Oliver, Trudy G, Mercer, Kim L, Sayles, Leanne C, Burke, James R, Mendus, Diana, Lovejoy, Katherine S, Cheng, Mei-Hsin, Subramanian, Aravind, Mu, David, Powers, Scott, Crowley, Denise, Bronson, Roderick T, Whittaker, Charles A, Bhutkar, Arjun, Lippard, Stephen J, Golub, Todd, Thomale, Juergen, Jacks, Tyler, Sweet-Cordero, E Alejandro

Volltext

Partners in Crime: Neutrophil–CTC Collusion in Metastasis von Guo, Bingqian, Oliver, Trudy G.

Volltext

GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer von Masin, Mark, Vazquez, Jessica, Rossi, Simona, Groeneveld, Svenja, Samson, Natasha, Schwalie, Petra C, Deplancke, Bart, Frawley, Laura E, Gouttenoire, Jérôme, Moradpour, Darius, Oliver, Trudy G, Meylan, Etienne

Volltext

Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer von Cargill, Kasey R., Stewart, C. Allison, Park, Elizabeth M., Ramkumar, Kavya, Gay, Carl M., Cardnell, Robert J., Wang, Qi, Diao, Lixia, Shen, Li, Fan, You-Hong, Chan, Wai Kin, Lorenzi, Philip L., Oliver, Trudy G., Wang, Jing, Byers, Lauren A.

Volltext

Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells von Melnikova, Margarita, Wauer, Ulrike Sophie, Mendus, Diana, Hilger, Ralf Axel, Oliver, Trudy G., Mercer, Kim, Gohlke, Björn Oliver, Erdmann, Kati, Niederacher, Dieter, Neubauer, Hans, Buderath, Paul, Wimberger, Pauline, Kuhlmann, Jan Dominik, Thomale, Jürgen

Volltext

Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development von Cowley, Dale O., Rivera-Pérez, Jaime A., Schliekelman, Mark, He, Yizhou Joseph, Oliver, Trudy G., Lu, Lucy, O'Quinn, Ryan, Salmon, E. D., Magnuson, Terry, Van Dyke, Terry

Volltext

Killing SCLC: insights into how to target a shapeshifting tumor von Sutherland, Kate D, Ireland, Abbie S, Oliver, Trudy G

Volltext

Tumor heterogeneity von Pe’er, Dana, Ogawa, Seishi, Elhanani, Ofer, Keren, Leeat, Oliver, Trudy G., Wedge, David

Volltext

Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells von Ireland, Abbie S., Oliver, Trudy G.

Volltext

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma von Oliver, Trudy G, Read, Tracy Ann, Kessler, Jessica D, Mehmeti, Anriada, Wells, Jonathan F, Huynh, Trang T T, Lin, Simon M, Wechsler-Reya, Robert J

Volltext