Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells von Okkenhaug, Klaus

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PI3K inhibitors are finally coming of age von Vanhaesebroeck, Bart, Perry, Matthew W. D., Brown, Jennifer R., André, Fabrice, Okkenhaug, Klaus

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PI3K inhibitors in inflammation, autoimmunity and cancer von Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus

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Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate von Bibby, Jack A., Purvis, Harriet A., Hayday, Thomas, Chandra, Anita, Okkenhaug, Klaus, Rosenzweig, Sofia, Aksentijevich, Ivona, Wood, Michael, Lachmann, Helen J., Kemper, Claudia, Cope, Andrew P., Perucha, Esperanza

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Tumors induce de novo steroid biosynthesis in T cells to evade immunity von Mahata, Bidesh, Pramanik, Jhuma, van der Weyden, Louise, Polanski, Krzysztof, Kar, Gozde, Riedel, Angela, Chen, Xi, Fonseca, Nuno A., Kundu, Kousik, Campos, Lia S., Ryder, Edward, Duddy, Graham, Walczak, Izabela, Okkenhaug, Klaus, Adams, David J., Shields, Jacqueline D., Teichmann, Sarah A.

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BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression von Grant, Francis M, Yang, Jie, Nasrallah, Rabab, Clarke, James, Sadiyah, Firas, Whiteside, Sarah K, Imianowski, Charlotte J, Kuo, Paula, Vardaka, Panagiota, Todorov, Tihomir, Zandhuis, Nordin, Patrascan, Ilinca, Tough, David F, Kometani, Kohei, Eil, Robert, Kurosaki, Tomohiro, Okkenhaug, Klaus, Roychoudhuri, Rahul

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Tissue-resident B cells orchestrate macrophage polarisation and function von Suchanek, Ondrej, Ferdinand, John R., Tuong, Zewen K., Wijeyesinghe, Sathi, Chandra, Anita, Clauder, Ann-Katrin, Almeida, Larissa N., Clare, Simon, Harcourt, Katherine, Ward, Christopher J., Bashford-Rogers, Rachael, Lawley, Trevor, Manz, Rudolf A., Okkenhaug, Klaus, Masopust, David, Clatworthy, Menna R.

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How to resist PI3Kδ inhibition: activate MAPK von Okkenhaug, Klaus

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span von Selman, Colin, Tullet, Jennifer M.A, Wieser, Daniela, Irvine, Elaine, Lingard, Steven J, Choudhury, Agharul I, Claret, Marc, Al-Qassab, Hind, Carmignac, Danielle, Ramadani, Faruk, Woods, Angela, Robinson, Iain C.A, Schuster, Eugene, Batterham, Rachel L, Kozma, Sara C, Thomas, George, Carling, David, Okkenhaug, Klaus, Thornton, Janet M, Partridge, Linda, Gems, David, Withers, Dominic J

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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner von Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus

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p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ von Guillermet-Guibert, Julie, Bjorklof, Katja, Salpekar, Ashreena, Gonella, Cristiano, Ramadani, Faruk, Bilancio, Antonio, Meek, Stephen, Smith, Andrew J.H, Okkenhaug, Klaus, Vanhaesebroeck, Bart

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Author Correction: PI3K inhibitors are finally coming of age von Vanhaesebroeck, Bart, Perry, Matthew W. D., Brown, Jennifer R., André, Fabrice, Okkenhaug, Klaus

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PI3K in T Cell Adhesion and Trafficking von Johansen, Kristoffer H, Golec, Dominic P, Thomsen, Julie H, Schwartzberg, Pamela L, Okkenhaug, Klaus

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A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2 von Vardaka, Panagiota, Lozano, Teresa, Bot, Christopher, Ellery, Jonathan, Whiteside, Sarah K., Imianowski, Charlotte J., Farrow, Stuart, Walker, Simon, Okkenhaug, Hanneke, Yang, Jie, Okkenhaug, Klaus, Kuo, Paula, Roychoudhuri, Rahul

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BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis von Imianowski, Charlotte J, Whiteside, Sarah K, Lozano, Teresa, Evans, Alexander C, Benson, Jayme D, Courreges, Christina J F, Sadiyah, Firas, Lau, Colleen M, Zandhuis, Nordin D, Grant, Francis M, Schuijs, Martijn J, Vardaka, Panagiota, Kuo, Paula, Soilleux, Elizabeth J, Yang, Jie, Sun, Joseph C, Kurosaki, Tomohiro, Okkenhaug, Klaus, Halim, Timotheus Y F, Roychoudhuri, Rahul

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Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model von Lau, Doreen, Garçon, Fabien, Chandra, Anita, Lechermann, Laura M, Aloj, Luigi, Chilvers, Edwin R, Corrie, Pippa G, Okkenhaug, Klaus, Gallagher, Ferdia A

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CELLULAR FUNCTION OF PHOSPHOINOSITIDE 3-KINASES: Implications for Development, Immunity, Homeostasis, and Cancer von Katso, Roy, Okkenhaug, Klaus, Ahmadi, Khatereh, White, Sarah, Timms, John, Waterfield, Michael D

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Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD -encoded phosphoinositide 3-kinase δ von Swan, David J, Aschenbrenner, Dominik, Lamb, Christopher A, Chakraborty, Krishnendu, Clark, Jonathan, Pandey, Sumeet, Engelhardt, Karin R, Chen, Rui, Cavounidis, Athena, Ding, Yuchun, Krasnogor, Natalio, Carey, Christopher D, Acres, Meghan, Needham, Stephanie, Cant, Andrew J, Arkwright, Peter D, Chandra, Anita, Okkenhaug, Klaus, Uhlig, Holm H, Hambleton, Sophie

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Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development von Courreges, Christina J F, Davenport, Elizabeth C M, Bilanges, Benoit, Rebollo-Gomez, Elena, Hukelmann, Jens, Schoenfelder, Priya, Edgar, James R, Sansom, David, Scudamore, Cheryl L, Roychoudhuri, Rahul, Garden, Oliver A, Vanhaesebroeck, Bart, Okkenhaug, Klaus

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PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells von Luff, Daisy H, Wojdyla, Katarzyna, Oxley, David, Chessa, Tamara, Hudson, Kevin, Hawkins, Phillip T, Stephens, Len R, Barry, Simon T, Okkenhaug, Klaus

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