Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress von Akiyama, Hiroki, Umezawa, Yoshihiro, Ishida, Shinya, Okada, Keigo, Nogami, Ayako, Miura, Osamu

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FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway von Okada, Keigo, Nogami, Ayako, Ishida, Shinya, Akiyama, Hiroki, Chen, Cheng, Umezawa, Yoshihiro, Miura, Osamu

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Efficacy and Safety of Balloon Kyphoplasty for Pathological Vertebral Fractures in Patients with Hematological Malignancies in Our Institution von Okada, Keigo, Fujiwara, Hiroki, Arimatsu, Tomoyuki, Motomura, Yotaro, Kato, Tsuyoshi, Takezako, Naoki, Kumagai, Takashi

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FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia von Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu

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Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including ne... von Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Oshikawa, Gaku, Nagao, Toshikage, Miura, Osamu

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Molecular mechanisms for enhancement of stromal cell-derived factor 1–induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1) von Umezawa, Yoshihiro, Akiyama, Hiroki, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Oshikawa, Gaku, Kurosu, Tetsuya, Miura, Osamu

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An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy von Izumi, Yuta, Kanayama, Masashi, Shen, Zhongchuzi, Kai, Masayuki, Kawamura, Shunsuke, Akiyama, Megumi, Yamamoto, Masahide, Nagao, Toshikage, Okada, Keigo, Kawamata, Norihiko, Toyota, Shigeo, Ohteki, Toshiaki

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Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD–Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pa... von Nogami, Ayako, Okada, Keigo, Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu

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Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma von Motomura, Yotaro, Umezawa, Yoshihiro, Arimatsu, Tomoyuki, Okada, Keigo, Miura, Osamu, Kumagai, Takashi

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FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM von Watanabe, Daisuke, Nogami, Ayako, Okada, Keigo, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu

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Evaluation of the efficacy of maintenance therapy for low-to-intermediate-risk acute promyelocytic leukemia in molecular remission: A retrospective single-institution study von Yamamoto, Masahide, Okada, Keigo, Akiyama, Hiroki, Kurosu, Tetsuya, Miura, Osamu

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Clinical factors for central nervous system progression and survival in primary vitreoretinal lymphoma von Motomura, Yotaro, Yoshifuji, Kota, Tachibana, Takayoshi, Takase, Hiroshi, Arai, Ayako, Tanaka, Keisuke, Okada, Keigo, Nogami, Ayako, Umezawa, Yoshihiro, Sakashita, Chizuko, Yamamoto, Masahide, Mori, Takehiko, Nagao, Toshikage

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FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bi... von Nogami, Ayako, Watanabe, Daisuke, Okada, Keigo, Akiyama, Hiroki, Umezawa, Yoshihiro, Nagao, Toshikage, Tohda, Shuji, Miura, Osamu

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Severe Motor Weakness Due to Disturbance in Peripheral Nerves Following Tisagenlecleucel Treatment von Kuboki, Mai, Umezawa, Yoshihiro, Motomura, Yotaro, Okada, Keigo, Nogami, Ayako, Nagao, Toshikage, Miura, Osamu, Yamamoto, Masahide

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Abstract 2167: A protease-mediated regulatory chimeric antigen receptor (CAR): “Scissors” CAR improves target-specificity through regulation of T-cell activity von Aoyama, Satoru, Yasuda, Shunichiro, Watanabe, Daisuke, Akiyama, Hiroki, Okada, Keigo, Umezawa, Yoshihiro, Nogami, Ayako, Miura, Osamu, Kawamata, Norihiko

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Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis von Tanaka, Keisuke, Ichikawa, Ayako, Umezawa, Natsuka, Yamamoto, Kouhei, Yoshifuji, Kota, Okada, Keigo, Nogami, Ayako, Umezawa, Yoshihiro, Nagao, Toshikage, Sakashita, Chizuko, Mori, Takehiko, Tohda, Shuji, Koike, Ryuji, Yasuda, Shinsuke, Yamamoto, Masahide

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Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells von Akiyama, Hiroki, Umezawa, Yoshihiro, Watanabe, Daisuke, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Miura, Osamu

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Efficacy and Safety of Balloon Kyphoplasty for Pathological Vertebral Fractures in Patients with Hematological Malignancies in Our Institution von Okada, Keigo, Fujiwara, Hiroki, Arimatsu, Tomoyuki, Motomura, Yotaro, Kato, Tsuyoshi, Takezako, Naoki, Kumagai, Takashi

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A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cell‑surface proteins on target c... von Aoyama, Satoru, Yasuda, Shunichiro, Li, Huixin, Watanabe, Daisuke, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Miura, Osamu, Kawamata, Norihiko

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Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells von Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Miura, Osamu

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