Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice von Kharas, Michael G., Okabe, Rachel, Ganis, Jared J., Gozo, Maricel, Khandan, Tulasi, Paktinat, Mahnaz, Gilliland, D. Gary, Gritsman, Kira

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Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera von Wernig, Gerlinde, Kharas, Michael G., Okabe, Rachel, Moore, Sandra A., Leeman, Dena S., Cullen, Dana E., Gozo, Maricel, McDowell, Elizabeth P., Levine, Ross L., Doukas, John, Mak, Chi Ching, Noronha, Glenn, Martin, Michael, Ko, Yon D., Lee, Benjamin H., Soll, Richard M., Tefferi, Ayalew, Hood, John D., Gilliland, D. Gary

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Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α von Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O, Roberts, Thomas M, Zhao, Jean J

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MSI2 is required for maintaining activated myelodysplastic syndrome stem cells von Taggart, James, Ho, Tzu-Chieh, Amin, Elianna, Xu, Haiming, Barlowe, Trevor S., Perez, Alexendar R., Durham, Benjamin H., Tivnan, Patrick, Okabe, Rachel, Chow, Arthur, Vu, Ly, Park, Sun Mi, Prieto, Camila, Famulare, Christopher, Patel, Minal, Lengner, Christopher J., Verma, Amit, Roboz, Gail, Guzman, Monica, Klimek, Virginia M., Abdel-Wahab, Omar, Leslie, Christina, Nimer, Stephen D., Kharas, Michael G.

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Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD von Rocnik, Jennifer L., Okabe, Rachel, Yu, Jin-Chen, Lee, Benjamin H., Giese, Neill, Schenkein, David P., Gilliland, D. Gary

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PKC412 Inhibits the Zinc Finger 198-Fibroblast Growth Factor Receptor 1 Fusion Tyrosine Kinase and Is Active in Treatment of Stem Cell Myeloproliferative Disorder von Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Galinsky, Ilene, Huntly, Brian, Cohen, Pamela S., Meyer, Thomas, Fabbro, Doriano, Roesel, Johannes, Banerji, Lolita, Griffin, James D., Xiao, Sheng, Fletcher, Jonathan A., Stone, Richard M., Gilliland, D. Gary, Witte, Owen N.

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Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias von KVINLAUG, Brynn T, CHAN, Wai-In, DE SILVA, Inusha, VALK, Peter J. M, DELWEL, Ruud, ARMSTRONG, Scott A, DÖHNER, Hartmut, GILLILAND, D. Gary, HUNTLY, Brian J. P, BULLINGER, Lars, RAMASWAMI, Mukundhan, SEARS, Christopher, FOSTER, Donna, LAZIC, Stanley E, OKABE, Rachel, BENNER, Axel, LEE, Benjamin H

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Expression of Jak2V617F causes a polycythemia vera–like disease with associated myelofibrosis in a murine bone marrow transplant model von Wernig, Gerlinde, Mercher, Thomas, Okabe, Rachel, Levine, Ross L., Lee, Benjamin H., Gilliland, D. Gary

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Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells von Mullally, Ann, Lane, Steven W., Ball, Brian, Megerdichian, Christine, Okabe, Rachel, Al-Shahrour, Fatima, Paktinat, Mahnaz, Haydu, J. Erika, Housman, Elizabeth, Lord, Allegra M., Wernig, Gerlinde, Kharas, Michael G., Mercher, Thomas, Kutok, Jeffery L., Gilliland, D. Gary, Ebert, Benjamin L.

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RON Kinase Is a Novel Therapeutic Target for Philadelphia-Negative Myeloproliferative Neoplasms von Gurska, Lindsay Meg, Okabe, Rachel, Tong, Meng Maxine, Choi, Daniel, Ames, Kristina, Glushakow-Smith, Shira, Montoya, Allison, Tein, Ellen, Cheng, Haiying, Goel, Swati, Halmos, Balazs, Gritsman, Kira

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Early Placental Insulin-Like Protein (INSL4 or EPIL) in Placental and Fetal Membrane Growth von MILLAR, Lynnae, STREINER, Nicole, WEBSTER, Lisa, YAMAMOTO, Sandra, OKABE, Rachel, KAWAMATA, Tasha, SHIMODA, Jacqueline, BÜLLESBACH, Erika, SCHWABE, Christian, BRYANT-GREENWOOD, Gillian

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Reduction of Nitric Oxide Synthase 2 Expression by Distamycin A Improves Survival from Endotoxemia von Baron, Rebecca M, Carvajal, Irvith M, Liu, Xiaoli, Okabe, Rachel O, Fredenburgh, Laura E, Macias, Alvaro A, Chen, Yen-Hsu, Ejima, Kuniaki, Layne, Matthew D, Perrella, Mark A

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Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms von Gurska, Lindsay M, Okabe, Rachel, Schurer, Alexandra, Tong, Meng Maxine, Soto, Mark, Choi, Daniel, Ames, Kristina, Glushakow-Smith, Shira, Montoya, Allison, Tein, Ellen, Miles, Linde A, Cheng, Haiying, Hankey-Giblin, Pamela, Levine, Ross L, Goel, Swati, Halmos, Balazs, Gritsman, Kira

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Abstract IA18: The PI3K isoforms in myeloid leukemia and hematopoietic stem cells von Hemmati, Shayda, Sinclair, Taneisha, Tong, Meng, Bartholdy, Boris, Okabe, Rachel, Ames, Kristina, Ostrodka, Leanne, Haque, Tamanna, Kaur, Imit, Agarwal, Anupriya, Zhao, Jean, Roberts, Thomas, Gritsman, Kira

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PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress von Hemmati, Shayda, Sinclair, Taneisha, Tong, Meng, Bartholdy, Boris, Okabe, Rachel, Ames, Kristina, Ostrodka, Leanne, Haque, Tamanna, Kaur, Imit, Agarwal, Anupriya, Zhao, Jean, Roberts, Thomas, Gritsman, Kira

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3059 - Pi3kinase Alpha and Delta Promote Hematopoietic Stem and Progenitor Cell Cycle Entry Under Stress von Hemmati, Shayda, Sinclair, Taneisha, Tong, Meng, Bartholdy, Boris, Ames, Kristina, Okabe, Rachel, Ostorodka, Leanne, Haque, Tamanna, Gritsman, Kira

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Pi3kinase Alpha and Delta Promote Hematopoietic Stem and Progenitor Cell Cycle Entry Under Stress von Hemmati, Shayda, Sinclair, Taneisha, Tong, Meng, Bartholdy, Boris, Ames, Kristina, Okabe, Rachel, Ostorodka, Leanne, Haque, Tamanna, Gritsman, Kira

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Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress von Xiao, Nan, Jani, Kaushal, Morgan, Kelly, Okabe, Rachel, Cullen, Dana E., Jesneck, Jonathan L., Raffel, Glen D.

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PI3K alpha and delta promote hematopoietic stem cell activation von Hemmati, Shayda, Sinclair, Taneisha, Tong, Meng, Bartholdy, Boris, Okabe, Rachel O., Ames, Kristina, Ostrodka, Leanne, Haque, Tamanna, Kaur, Imit, Mills, Taylor S., Agarwal, Anupriya, Pietras, Eric M., Zhao, Jean J., Roberts, Thomas M., Gritsman, Kira

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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia von Kharas, Michael G, Lengner, Christopher J, Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W, Scholl, Claudia, Fröhling, Stefan, Fleming, Mark, Ebert, Benjamin L, Gilliland, D Gary, Jaenisch, Rudolf, Daley, George Q

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