CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant von Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko

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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802) von Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer von Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Tanimura, Hiromi, Yoshida, Miyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Tachibana, Yukako, Takanashi, Kenji, Higashida, Atsuko, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Mio, Toshiyuki

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High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity von Wheelock, Craig E., Nakagawa, Yoshiaki, Harada, Toshiyuki, Oikawa, Nobuhiro, Akamatsu, Miki, Smagghe, Guy, Stefanou, Dimitra, Iatrou, Kostas, Swevers, Luc

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MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor von Aida, Satoshi, Sonobe, Yukiko, Tanimura, Hiromi, Oikawa, Nobuhiro, Yuhki, Munehiro, Sakamoto, Hiroshi, Mizuno, Takakazu

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Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole von Ohwada, Jun, Tsukazaki, Masao, Hayase, Tadakatsu, Oikawa, Nobuhiro, Isshiki, Yoshiaki, Fukuda, Hiroshi, Mizuguchi, Eisaku, Sakaitani, Masahiro, Shiratori, Yasuhiko, Yamazaki, Toshikazu, Ichihara, Shigeyasu, Umeda, Isao, Shimma, Nobuo

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Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor von Ito, Toshiya, Kinoshita, Kazutomo, Tomizawa, Masaki, Shinohara, Shojiro, Nishii, Hiroki, Matsushita, Masayuki, Hattori, Kazuo, Kohchi, Yasunori, Kohchi, Masami, Hayase, Tadakatsu, Watanabe, Fumio, Hasegawa, Kiyoshi, Tanaka, Hiroshi, Kuramoto, Shino, Takanashi, Kenji, Oikawa, Nobuhiro

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Abstract 4179: Potent and selective TRK inhibitor CH7057288 von Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Tanimura, Hiromi, Hasegawa, Masami, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Sakamoto, Hiroshi, Mio, Toshiyuki

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors von Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Abstract DDT01-02: CH5424802: A selective ALK inhibitor von Sakamoto, Hiroshi, Oikawa, Nobuhiro, Tsukuda, Takuo, Shimma, Nobuo, Ishii, Nobuya, Aoki, Yuko

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Quantitative structure-activity analysis of larvicidal 1-(substituted benzoyl)-2-benzoyl-1-tert-butylhydrazines against Chilo suppressalis von Oikawa, Nobuhiro, Nakagawa, Yoshiaki, Nishimura, Keiichiro, Ueno, Tamio, Fujita, Toshio

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Abstract 3559: A new selective ALK inhibitor CH5424802 shows potent efficacy against ALK-positive cancers including the gatekeeper mutant-driven tumors von Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko

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Hydrophilically functionalized pyrazoles from sugars11Enantiopure Building Blocks from Sugars. Part 22. For Part 21, see Ref.[1].—Presented, in part, at the 9th European Carbohydra... von Oikawa, Nobuhiro, Müller, Christoph, Kunz, Markwart, Lichtenthaler, Frieder W

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Abstract 3593: Generation of a potent and selective inhibitor of ALK, CH5424802, showing superior oral bioavailability, PK profile and in vivo efficacy von Oikawa, Nobuhiro, Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Itoh, Toshiya, Kawada, Hatsuo, Hara, Sosuke, Miyagi, Takuho, Ohwada, Jun, Taniguchi, Saori, Hattori, Kazuo, Tsukuda, Takuo, Takanashi, Kenji, Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Ishii, Nobuya, Aoki, Yuko, Shimma, Nobuo

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Quantitative structure-activity studies of insect growth regulators. XI. Stimulation and inhibition of N-acetylglucosamine incorporation in a cultured integument system by substitu... von Nakagawa, Yoshiaki, Soya, Yoshihiro, Nakai, Katsumi, Oikawa, Nobuhiro, Nishimura, Keiichiro, Ueno, Tamio, Fujita, Toshio, Kurihara, Norio

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Identification of a Novel Vascular Endothelial Growth Factor Receptor 2 Inhibitor and Its Effect for Choroidal Neovascularization In Vivo von Takahashi, Hidenori, Tamaki, Yasuhiro, Ishii, Nobuya, Oikawa, Nobuhiro, Mizuguchi, Eisaku, Francis, Jasmine H., Inoue, Yuji, Iriyama, Aya, Obata, Ryo, Yanagi, Yasuo

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Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues von Kohchi, Yasunori, Hattori, Kazuo, Oikawa, Nobuhiro, Mizuguchi, Eisaku, Isshiki, Yoshiaki, Aso, Kohsuke, Yoshinari, Kiyoshi, Shirai, Haruyoshi, Miwa, Masanori, Inagaki, Yukiko, Ura, Masako, Ogawa, Kotaroh, Okabe, Hisafumi, Ishitsuka, Hideo, Shimma, Nobuo

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Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine von Hattori, Kazuo, Kohchi, Yasunori, Oikawa, Nobuhiro, Suda, Hitomi, Ura, Masako, Ishikawa, Tohru, Miwa, Masanori, Endoh, Mika, Eda, Hiroyuki, Tanimura, Hiromi, Kawashima, Akira, Horii, Ikuo, Ishitsuka, Hideo, Shimma, Nobuo

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