Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells von Fujimoto, Yumi, Morita, Tomoko Yamamori, Ohashi, Akihiro, Haeno, Hiroshi, Hakozaki, Yumi, Fujii, Masanori, Kashima, Yukie, Kobayashi, Susumu S., Mukohara, Toru

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Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation von Du, Junyan, Kageyama, Shun‐Ichiro, Yamashita, Riu, Hirata, Hidenari, Hakozaki, Yumi, Okumura, Masayuki, Motegi, Atsushi, Hojo, Hidehiro, Nakamura, Masaki, Hirano, Yasuhiro, Sunakawa, Hironori, Minamide, Tatsunori, Kotani, Daisuke, Tanaka, Kosuke, Yano, Tomonori, Kojima, Takashi, Ohashi, Akihiro, Tsuchihara, Katsuya, Akimoto, Tetsuo

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Report of the use of patient‐derived xenograft models in the development of anticancer drugs in Japan von Tsumura, Ryo, Koga, Yoshikatsu, Hamada, Akinobu, Kuwata, Takeshi, Sasaki, Hiroki, Doi, Toshihiko, Aikawa, Katsuji, Ohashi, Akihiro, Katano, Ikumi, Ikarashi, Yoshinori, Ito, Mamoru, Ochiai, Atsushi

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Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens von Kashima, Yukie, Togashi, Yosuke, Fukuoka, Shota, Kamada, Takahiro, Irie, Takuma, Suzuki, Ayako, Nakamura, Yoshiaki, Shitara, Kohei, Minamide, Tatsunori, Yoshida, Taku, Taoka, Naofumi, Kawase, Tatsuya, Wada, Teiji, Inaki, Koichiro, Chihara, Masataka, Ebisuno, Yukihiko, Tsukamoto, Sakiyo, Fujii, Ryo, Ohashi, Akihiro, Suzuki, Yutaka, Tsuchihara, Katsuya, Nishikawa, Hiroyoshi, Doi, Toshihiko

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Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2 von Xia, Bing, Sheng, Qing, Nakanishi, Koji, Ohashi, Akihiro, Wu, Jianmin, Christ, Nicole, Liu, Xinggang, Jasin, Maria, Couch, Fergus J., Livingston, David M.

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Long-read sequencing for non-small-cell lung cancer genomes von Sakamoto, Yoshitaka, Xu, Liu, Seki, Masahide, Yokoyama, Toshiyuki T, Kasahara, Masahiro, Kashima, Yukie, Ohashi, Akihiro, Shimada, Yoko, Motoi, Noriko, Tsuchihara, Katsuya, Kobayashi, Susumu S, Kohno, Takashi, Shiraishi, Yuichi, Suzuki, Ayako, Suzuki, Yutaka

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CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade von Morita, Tomoko Yamamori, Yu, Jie, Kashima, Yukie, Kamata, Ryo, Yamamoto, Gaku, Minamide, Tatsunori, Mashima, Chiaki, Yoshiya, Miyuki, Sakae, Yuta, Yamauchi, Toyohiro, Hakozaki, Yumi, Kageyama, Shun-ichiro, Nakamura, Akito, Lightcap, Eric, Tanaka, Kosuke, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro

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A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity von Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nambu, Tadahiro, Miyamoto, Maki, Kawamoto, Tomohiro, Okaniwa, Masanori

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TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma von Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J

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Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway von Nakai, Kazuki, Lin, Hancheng, Yamano, Shotaro, Tanaka, Shinya, Kitamoto, Sho, Saitoh, Hitoshi, Sakuma, Kenta, Kurauchi, Junpei, Akter, Eilma, Konno, Masamitsu, Ishibashi, Kojiro, Kamata, Ryo, Ohashi, Akihiro, Koseki, Jun, Takahashi, Hirotaka, Yokoyama, Hideshi, Shiraki, Yukihiro, Enomoto, Atsushi, Abe, Sohei, Hayakawa, Yoku, Ushiku, Tetsuo, Mutoh, Michihiro, Fujita, Yasuyuki, Kon, Shunsuke

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Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice von Rowley, Matthew, Ohashi, Akihiro, Mondal, Gourish, Mills, Lisa, Yang, Lin, Zhang, Lizhi, Sundsbak, Rhianna, Shapiro, Virginia, Muders, Michael H, Smyrk, Thomas, Couch, Fergus J

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Tex14, a Plk1-Regulated Protein, Is Required for Kinetochore-Microtubule Attachment and Regulation of the Spindle Assembly Checkpoint von Mondal, Gourish, Ohashi, Akihiro, Yang, Lin, Rowley, Matthew, Couch, Fergus J.

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Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one... von Kurasawa, Osamu, Oguro, Yuya, Miyazaki, Tohru, Homma, Misaki, Mori, Kouji, Iwai, Kenichi, Hara, Hideto, Skene, Robert, Hoffman, Isaac, Ohashi, Akihiro, Yoshida, Sei, Ishikawa, Tomoyasu, Cho, Nobuo

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Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor von Iwai, Kenichi, Nambu, Tadahiro, Dairiki, Ryo, Ohori, Momoko, Yu, Jie, Burke, Kristine, Gotou, Masamitsu, Yamamoto, Yukiko, Ebara, Shunsuke, Shibata, Sachio, Hibino, Ryosuke, Nishizawa, Satoru, Miyazaki, Tohru, Homma, Misaki, Oguro, Yuya, Imada, Takashi, Cho, Nobuo, Uchiyama, Noriko, Kogame, Akifumi, Takeuchi, Toshiyuki, Kurasawa, Osamu, Yamanaka, Kazunori, Niu, Huifeng, Ohashi, Akihiro

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Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions von Yamashima, Tetsumori, Mochly-Rosen, Daria, Wakatsuki, Soichi, Mizukoshi, Eishiro, Seike, Takuya, Larus, Isabel Maria, Chen, Che-Hong, Takemura, Miho, Saito, Hisashi, Ohashi, Akihiro

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A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery von Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro

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Expression data of HeLa cells treated with CENP-E siRNA or Eg5 siRNA in the presence of BubR1 siRNA von Nakayama, Yusuke, Ohashi, Akihiro

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Mating Disruption of a Flighted Spongy Moth, Lymantria Dispar Japonica (Motchulsky) in Japan von Minegishi, Hiroyuki, Ohashi, Akihiro, Nakamuta, Kiyoshi

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Functional evaluation and cancer risk assessment of BRCA2 unclassified variants von KANGJIAN WU, HINSON, Shannon R, OHASHI, Akihiro, FARRUGIA, Daniel, WENDT, Patricia, TAVTIGIAN, Sean V, DEFFENBAUGH, Amie, GOLDGAR, David, COUCH, Fergus J

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Fanconi Anemia Complementation Group D2 (FANCD2) Functions Independently of BRCA2- and RAD51-associated Homologous Recombination in Response to DNA Damage von Ohashi, Akihiro, Zdzienicka, Malgorzata Z., Chen, Junjie, Couch, Fergus J.

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