Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion von Pound, Lynley D, Sarkar, Suparna A, Benninger, Richard K P, Wang, Yingda, Suwanichkul, Adisak, Shadoan, Melanie K, Printz, Richard L, Oeser, James K, Lee, Catherine E, Piston, David W, McGuinness, Owen P, Hutton, John C, Powell, David R, O'Brien, Richard M

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Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model von Hawes, Emily M, Claxton, Derek P, Oeser, James K, O'Brien, Richard M

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Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion von Syring, Kristen E, Boortz, Kayla A, Oeser, James K, Ustione, Alessandro, Platt, Kenneth A, Shadoan, Melanie K, McGuinness, Owen P, Piston, David W, Powell, David R, O'Brien, Richard M

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G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion von POUND, Lynley D, OESER, James K, O'BRIEN, Richard M, O'BRIEN, Tracy P, YINGDA WANG, FAULMAN, Chandler J, DADI, Prasanna K, JACOBSON, David A, HUTTON, John C, MCGUINNESS, Owen P, SHIOTA, Masakazu

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Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose von Bosma, Karin J, Rahim, Mohsin, Singh, Kritika, Goleva, Slavina B, Wall, Martha L, Xia, Jing, Syring, Kristen E, Oeser, James K, Poffenberger, Greg, McGuinness, Owen P, Means, Anna L, Powers, Alvin C, Li, Wen-hong, Davis, Lea K, Young, Jamey D, O’Brien, Richard M

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Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids o... von Boortz, Kayla A, Syring, Kristen E, Pound, Lynley D, Wang, Yingda, Oeser, James K, O'Brien, Richard M

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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting von Bosma, Karin J., Rahim, Mohsin, Oeser, James K., McGuinness, Owen P., Young, Jamey D., O'Brien, Richard M.

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The Glucose-6-Phosphatase Catalytic Subunit Gene Promoter Contains Both Positive and Negative Glucocorticoid Response Elements von Vander Kooi, Beth T, Onuma, Hiroshi, Oeser, James K, Svitek, Christina A, Allen, Shelley R, Vander Kooi, Craig W, Chazin, Walter J, O’Brien, Richard M

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The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer von Pound, Lynley D, Hang, Yan, Sarkar, Suparna A, Wang, Yingda, Milam, Laurel A, Oeser, James K, Printz, Richard L, Lee, Catherine E, Stein, Roland, Hutton, John C, O'Brien, Richard M

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Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) Binding and the Inhibition of Basal Glucose-6-Phosphatase Catalytic Subunit Gene Transcription by Insulin von Onuma, Hiroshi, Vander Kooi, Beth T, Boustead, Jared N, Oeser, James K, O’Brien, Richard M

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Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1 von Claxton, Derek P., Overway, Emily M., Oeser, James K., O'Brien, Richard M., Mchaourab, Hassane S.

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G6PC1 and G6PC2 influence glucose-6-phosphate flux but not 11β-hydroxysteroid dehydrogenase type 1 activity von Hawes, Emily M., Boortz, Kayla A., Oeser, James K, O'Rourke, Margaret L, O'Brien, Richard M

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G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity von Hawes, Emily M, Boortz, Kayla A, Oeser, James K, O'Rourke, Margaret L, O'Brien, Richard M

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Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose von Overway, Emily M., Bosma, Karin J., Claxton, Derek P., Oeser, James K., Singh, Kritika, Breidenbach, Lindsay B., Mchaourab, Hassane S., Davis, Lea K., O'Brien, Richard M.

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Biochemical and metabolic characterization of a G6PC2 inhibitor von Hawes, Emily M., Rahim, Mohsin, Haratipour, Zeinab, Orun, Abigail R., O'Rourke, Margaret L., Oeser, James K., Kim, Kwangho, Claxton, Derek P., Blind, Ray D., Young, Jamey D., O'Brien, Richard M.

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An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets von Keller, Mark P, Hawes, Emily M, Schueler, Kathryn L, Stapleton, Donnie S, Mitok, Kelly A, Simonett, Shane P, Oeser, James K, Sampson, Leesa L, Attie, Alan D, Magnuson, Mark A, O'Brien, Richard M

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Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells von Rahim, Mohsin, Nakhe, Arya Y., Banerjee, Deveena R., Overway, Emily M., Bosma, Karin J., Rosch, Jonah C., Oeser, James K., Wang, Bo, Lippmann, Ethan S., Jacobson, David A., O'Brien, Richard M., Young, Jamey D.

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Potential positive and negative consequences of ZnT8 inhibition von Syring, Kristen E, Bosma, Karin J, Goleva, Slavina B, Singh, Kritika, Oeser, James K, Lopez, Christopher A, Skaar, Eric P, McGuinness, Owen P, Davis, Lea K, Powell, David R, O’Brien, Richard M

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Characterization of the human SLC30A8 promoter and intronic enhancer von Pound, Lynley D, Sarkar, Suparna A, Cauchi, Stéphane, Wang, Yingda, Oeser, James K, Lee, Catherine E, Froguel, Philippe, Hutton, John C, O'Brien, Richard M

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The Three Insulin Response Sequences in the Glucose-6-phosphatase Catalytic Subunit Gene Promoter Are Functionally Distinct von Vander Kooi, Beth T, Streeper, Ryan S, Svitek, Christina A, Oeser, James K, Powell, David R, O'Brien, Richard M

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