Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells von Cribbs, Adam, Hookway, Edward S., Wells, Graham, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Prinjha, Rab K., Athanasou, Nick, Sowman, Aneka, Philpott, Martin, Penn, Henry, Soderstrom, Kalle, Feldmann, Marc, Oppermann, Udo

Volltext

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism von Cribbs, Adam P., Terlecki-Zaniewicz, Stefan, Philpott, Martin, Baardman, Jeroen, Ahern, David, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Sampey, Brante, Mander, Palwinder K., Penn, Henry, Wordsworth, Paul, Bowness, Paul, de Winther, Menno, Prinjha, Rab K., Feldmann, Marc, Oppermann, Udo

Volltext

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells von Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Wang, LiAnn, Ren, Xiao-Qin, Soifer, Harris S, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Armstrong, Brian, Wang, Zhigang, Bauer, Paul, Rossi, John, Stein, C A

Volltext

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function von Cribbs, Adam P, Filippakopoulos, Panagis, Philpott, Martin, Wells, Graham, Penn, Henry, Oerum, Henrik, Valge-Archer, Viia, Feldmann, Marc, Oppermann, Udo

Volltext

Silencing of Gene Expression by Gymnotic Delivery of Antisense Oligonucleotides von Soifer, Harris S., Koch, Troels, Lai, Johnathan, Hansen, Bo, Hoeg, Anja, Oerum, Henrik, Stein, C. A.

Volltext

Potent and Nontoxic Antisense Oligonucleotides Containing Locked Nucleic Acids von Wahlestedt, Claes, Salmi, Peter, Good, Liam, Kela, Johanna, Johnsson, Thomas, Hokfelt, Tomas, Broberger, Christian, Porreca, Frank, Lai, Josephine, Ren, Kunkun, Ossipov, Michael, Koshkin, Alexei, Jakobsen, Nana, Skouv, Jan, Oerum, Henrik, Jacobsen, Mogens Havsteen, Wengel, Jesper

Volltext

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates von Straarup, Ellen Marie, Fisker, Niels, Hedtjärn, Maj, Lindholm, Marie W, Rosenbohm, Christoph, Aarup, Vibeke, Hansen, Henrik Frydenlund, Ørum, Henrik, Hansen, Jens B. Rode, Koch, Troels

Volltext

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents von Stein, C.A, Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S, Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels

Volltext

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo von Gupta, Nidhi, Fisker, Niels, Asselin, Marie-Claude, Lindholm, Marie, Rosenbohm, Christoph, Ørum, Henrik, Elmén, Joacim, Seidah, Nabil G, Straarup, Ellen Marie

Volltext

A simple, safe and sensitive method for SARS‐CoV‐2 inactivation and RNA extraction for RT‐qPCR von Kalnina, Lelde, Mateu‐Regué, Àngels, Oerum, Stephanie, Hald, Annemette, Gerstoft, Jan, Oerum, Henrik, Nielsen, Finn Cilius, Iversen, Astrid K. N.

Volltext

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells von Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Stein, Cy A

Volltext

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern von Hagedorn, Peter H., Yakimov, Victor, Ottosen, Søren, Kammler, Susanne, Nielsen, Niels F., Høg, Anja M., Hedtjärn, Maj, Meldgaard, Michael, Møller, Marianne R., Ørum, Henrik, Koch, Troels, Lindow, Morten

Volltext

Protein Kinase C-[alpha] is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells von Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Stein, Cy A

Volltext

Quantum Mechanical Studies of DNA and LNA von Koch, Troels, Shim, Irene, Lindow, Morten, Ørum, Henrik, Bohr, Henrik G.

Volltext

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides von Fluiter, Kees, ten Asbroek, Anneloor L. M. A., de Wissel, Marit B., Jakobs, Marja E., Wissenbach, Margit, Olsson, Håkan, Olsen, Otto, Oerum, Henrik, Baas, Frank

Volltext

Histone Demethylase Inhibition As a Novel Therapeutic Strategy in Myeloma von Pawlyn, Charlotte, Hookway, Edward, Cain, Peter, Pliuskys, Laurynas, Kaiser, Martin F, Bright, Michael, Aronson, Lauren I, Murison, Alexander, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Opperman, Udo, Morgan, Gareth J., Davies, Faith E

Volltext

Abstract SY31-02: Locked nucleic acid (LNA)-modified antisense oligonucleotides as anticancer agents: Using high-affinity antisense molecules in the laboratory and in the clinic von Levin, Arthur A., Greenberger, Lee M., Buchbinder, Aby, Hansen, Bo R., Hedtjärn, Maj, Kauppinen, Sakari, Oerum, Henrik, Horak, Ivan D.

Volltext

On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide von Fluiter, Kees, Frieden, Miriam, Vreijling, Jeroen, Rosenbohm, Christoph, De Wissel, Marit B, Christensen, Signe M, Koch, Troels, Ørum, Henrik, Baas, Frank

Volltext

ORAL DELIVERY OF ANTISENSE CONJUGATES TARGETING PCSK9 von SHEAR, Charles Lester, NOBLE, Stewart Alwyn, OERUM, Henrik

Volltext bestellen

ORAL DELIVERY OF OLIGONUCLEOTIDES von NOBLE, Stewart Alwyl, SHEAR, Charles Lester, OERUM, Henrik

Volltext bestellen