Post-translational insertion of boron in proteins to probe and modulate function von Mollner, Tim A., Isenegger, Patrick G., Josephson, Brian, Buchanan, Charles, Lercher, Lukas, Oehlrich, Daniel, Hansen, D. Flemming, Mohammed, Shabaz, Baldwin, Andrew J., Gouverneur, Véronique, Davis, Benjamin G.

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Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis von Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.

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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glut... von Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Iturrino, Laura, Linares, María Lourdes, Garcia, Aránzazu, Andrés, José Ignacio, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Megens, Anton, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A

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Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)­methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailab... von Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A

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Suzuki–Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs von Fleury-Brégeot, Nicolas, Presset, Marc, Beaumard, Floriane, Colombel, Virginie, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A

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Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor von de Lucas, Ana I, Vega, Juan A, García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A, Cid, José M

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Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ‑Fluoroamines von Roagna, Giulia, Ascough, David M. H, Ibba, Francesco, Vicini, Anna Chiara, Fontana, Alberto, Christensen, Kirsten E, Peschiulli, Aldo, Oehlrich, Daniel, Misale, Antonio, Trabanco, Andrés A, Paton, Robert S, Pupo, Gabriele, Gouverneur, Véronique

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Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection von Cacace, Rita, Zhou, Lujia, van de Craen, Elisabeth Hendrickx, Buist, Arjan, Hoogmartens, Julie, Sieben, Anne, Cras, Patrick, Vandenberghe, Rik, De Deyn, Peter P, Oehlrich, Daniel, De Bondt, An, Engelborghs, Sebastiaan, Moechars, Diederik, Van Broeckhoven, Christine

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Mutated Toll-like receptor 9 increases Alzheimer’s disease risk by compromising innate immunity protection von Cacace, Rita, Zhou, Lujia, Hendrickx Van de Craen, Elisabeth, Buist, Arjan, Hoogmartens, Julie, Sieben, Anne, Cras, Patrick, Vandenberghe, Rik, De Deyn, Peter P., Oehlrich, Daniel, De Bondt, An, Engelborghs, Sebastiaan, Moechars, Diederik, Van Broeckhoven, Christine

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Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M3) receptors von Bradshaw, Benjamin, Evans, Paul, Fletcher, Jane, Lee, Alan T L, Mwashimba, Paul G, Oehlrich, Daniel, Thomas, Eric J, Davies, Robin H, Allen, Benjamin C P, Broadley, Kenneth J, Hamrouni, Amar, Escargueil, Christine

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Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides von Wright, Miranda, Martínez-Lamenca, Carolina, Leenaerts, Joseph E, Brennan, Paul E, Trabanco, Andrés A, Oehlrich, Daniel

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1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads von Rombouts, Frederik J. R, Tresadern, Gary, Delgado, Oscar, Martínez-Lamenca, Carolina, Van Gool, Michiel, García-Molina, Aránzazu, Alonso de Diego, Sergio A, Oehlrich, Daniel, Prokopcova, Hana, Alonso, José Manuel, Austin, Nigel, Borghys, Herman, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Alexander, Richard, Macdonald, Gregor, Moechars, Dieder, Gijsen, Harrie, Trabanco, Andrés A

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Publisher Correction: Post-translational insertion of boron in proteins to probe and modulate function von Mollner, Tim A., Isenegger, Patrick G., Josephson, Brian, Buchanan, Charles, Lercher, Lukas, Oehlrich, Daniel, Hansen, D. Flemming, Mohammed, Shabaz, Baldwin, Andrew J., Gouverneur, Véronique, Davis, Benjamin G.

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Industrial medicinal chemistry insights: neuroscience hit generation at Janssen von Tresadern, Gary, Rombouts, Frederik J.R., Oehlrich, Daniel, Macdonald, Gregor, Trabanco, Andres A.

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Optimization of 1,4-Oxazine β‑Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate von Gijsen, Harrie J. M, Alonso de Diego, Sergio A, De Cleyn, Michel, García-Molina, Aránzazu, Macdonald, Gregor J, Martínez-Lamenca, Carolina, Oehlrich, Daniel, Prokopcova, Hana, Rombouts, Frederik J. R, Surkyn, Michel, Trabanco, Andrés A, Van Brandt, Sven, Van den Bossche, Dries, Van Gool, Michiel, Austin, Nigel, Borghys, Herman, Dhuyvetter, Deborah, Moechars, Diederik

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Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor von Trabanco, Andrés A, Tresadern, Gary, Macdonald, Gregor J, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, García, Aránzazu, Linares, María Lourdes, Alonso de Diego, Sergio A, Alonso, José Manuel, Oehlrich, Daniel, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Andrés, José Ignacio, Lavreysen, Hilde, Cid, José María

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Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptors von de Lucas, Ana, Vega, Juan A., Garcia Molina, Aranzazu, Lourdes Linares, Maria, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andres A., Cid, Jose M.

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A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo von Peschiulli, Aldo, Oehlrich, Daniel, Van Gool, Michiel, Austin, Nigel, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Tresadern, Gary, Rombouts, Frederik J. R, Macdonald, Gregor J, Moechars, Diederik, Trabanco, Andrés A, Gijsen, Harrie J. M

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Scaffold hopping from pyridones to imidazo[1,2- a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor von Tresadern, Gary, Cid, Jose María, Macdonald, Gregor J., Vega, Juan Antonio, de Lucas, Ana Isabel, García, Aránzazu, Matesanz, Encarnación, Linares, María Lourdes, Oehlrich, Daniel, Lavreysen, Hilde, Biesmans, Ilse, Trabanco, Andrés A.

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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome von Matico, Rosalie, Grauwen, Karolien, Chauhan, Dhruv, Yu, Xiaodi, Abdiaj, Irini, Adhikary, Suraj, Adriaensen, Ine, Aranzazu, Garcia Molina, Alcázar, Jesus, Bassi, Michela, Brisse, Ellen, Cañellas, Santiago, Chaudhuri, Shubhra, Delgado, Francisca, Diéguez-Vázquez, Alejandro, Du Jardin, Marc, Eastham, Victoria, Finley, Michael, Jacobs, Tom, Keustermans, Ken, Kuhn, Robert, Llaveria, Josep, Leenaerts, Jos, Linares, Maria Lourdes, Martín, Maria Luz, Martín-Pérez, Rosa, Martínez, Carlos, Miller, Robyn, Muñoz, Frances M, Muratore, Michael E, Nooyens, Amber, Perez-Benito, Laura, Perrier, Mathieu, Pietrak, Beth, Serré, Jef, Sharma, Sujata, Somers, Marijke, Suarez, Javier, Tresadern, Gary, Trabanco, Andres A, Van den Bulck, Dries, Van Gool, Michiel, Van Hauwermeiren, Filip, Varghese, Teena, Vega, Juan Antonio, Youssef, Sameh A, Edwards, Matthew J, Oehlrich, Daniel, Van Opdenbosch, Nina

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