TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma von Teramachi, Jumpei, Tenshin, Hirofumi, Hiasa, Masahiro, Oda, Asuka, Bat-Erdene, Ariunzaya, Harada, Takeshi, Nakamura, Shingen, Ashtar, Mohannad, Shimizu, So, Iwasa, Masami, Sogabe, Kimiko, Oura, Masahiro, Fujii, Shiro, Kagawa, Kumiko, Miki, Hirokazu, Endo, Itsuro, Haneji, Tatsuji, Matsumoto, Toshio, Abe, Masahiro

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Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth von Takeuchi, Kyoko, Abe, Masahiro, Hiasa, Masahiro, Oda, Asuka, Amou, Hiroe, Kido, Shinsuke, Harada, Takeshi, Tanaka, Osamu, Miki, Hirokazu, Nakamura, Shingen, Nakano, Ayako, Kagawa, Kumiko, Yata, Kenichiro, Ozaki, Shuji, Matsumoto, Toshio

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Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors von Nakaue, Emiko, Teramachi, Jumpei, Tenshin, Hirofumi, Hiasa, Masahiro, Harada, Takeshi, Oda, Asuka, Inoue, Yusuke, Shimizu, So, Higa, Yoshiki, Sogabe, Kimiko, Oura, Masahiro, Hara, Tomoyo, Sumitani, Ryohei, Maruhashi, Tomoko, Yamagami, Hiroki, Endo, Itsuro, Tanaka, Eiji, Abe, Masahiro

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Mechanical unloading aggravates bone destruction and tumor expansion in myeloma von Tanimoto, Kotaro, Hiasa, Masahiro, Tenshin, Hirofumi, Teramachi, Jumpei, Oda, Asuka, Harada, Takeshi, Higa, Yoshiki, Sogabe, Kimiko, Oura, Masahiro, Sumitani, Ryohei, Hara, Tomoyo, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro

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Pim‐2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma von Teramachi, Jumpei, Hiasa, Masahiro, Oda, Asuka, Harada, Takeshi, Nakamura, Shingen, Amachi, Ryota, Tenshin, Hirofumi, Iwasa, Masami, Fujii, Shiro, Kagawa, Kumiko, Miki, Hirokazu, Kurahashi, Kiyoe, Yoshida, Sumiko, Endo, Itsuro, Haneji, Tatsuji, Matsumoto, Toshio, Abe, Masahiro

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The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat von Ashtar, Mohannad, Tenshin, Hirofumi, Teramachi, Jumpei, Bat-Erdene, Ariunzaya, Hiasa, Masahiro, Oda, Asuka, Tanimoto, Kotaro, Shimizu, So, Higa, Yoshiki, Harada, Takeshi, Oura, Masahiro, Sogabe, Kimiko, Nakamura, Shingen, Fujii, Shiro, Sumitani, Ryohei, Miki, Hirokazu, Udaka, Kengo, Takahashi, Mamiko, Kagawa, Kumiko, Endo, Itsuro, Tanaka, Eiji, Matsumoto, Toshio, Abe, Masahiro

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Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells von Nakano, Ayako, Tsuji, Daisuke, Miki, Hirokazu, Cui, Qu, El Sayed, Salah Mohamed, Ikegame, Akishige, Oda, Asuka, Amou, Hiroe, Nakamura, Shingen, Harada, Takeshi, Fujii, Shiro, Kagawa, Kumiko, Takeuchi, Kyoko, Sakai, Akira, Ozaki, Shuji, Okano, Kazuma, Nakamura, Takahiro, Itoh, Kohji, Matsumoto, Toshio, Abe, Masahiro

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Myeloma Cell-Osteoclast Interaction Enhances Angiogenesis Together with Bone Resorption: A Role for Vascular Endothelial Cell Growth Factor and Osteopontin von TANAKA, Yoichi, ABE, Masahiro, MORIYAMA, Keiji, HASHIMOTO, Toshihiro, OZAKI, Shuji, MATSUMOTO, Toshio, HIASA, Masahiro, ODA, Asuka, AMOU, Hiroe, NAKANO, Ayako, TAKEUCHI, Kyoko, KITAZOE, Kenichi, KIDO, Shinsuke, INOUE, Daisuke

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The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2 von Higa, Yoshiki, Hiasa, Masahiro, Tenshin, Hirofumi, Nakaue, Emiko, Tanaka, Mariko, Kim, Sooha, Nakagawa, Motosumi, Shimizu, So, Tanimoto, Kotaro, Teramachi, Jumpei, Harada, Takeshi, Oda, Asuka, Oura, Masahiro, Sogabe, Kimiko, Hara, Tomoyo, Sumitani, Ryohei, Maruhashi, Tomoko, Yamagami, Hiroki, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro

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Association of Th1 and Th2 cytokines with transient inflammatory reaction during lenalidomide plus dexamethasone therapy in multiple myeloma von Harada, Takeshi, Ozaki, Shuji, Oda, Asuka, Fujii, Shiro, Nakamura, Shingen, Miki, Hirokazu, Kagawa, Kumiko, Takeuchi, Kyoko, Matsumoto, Toshio, Abe, Masahiro

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TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α... von Tenshin, Hirofumi, Teramachi, Jumpei, Ashtar, Mohannad, Hiasa, Masahiro, Inoue, Yusuke, Oda, Asuka, Tanimoto, Kotaro, Shimizu, So, Higa, Yoshiki, Harada, Takeshi, Oura, Masahiro, Sogabe, Kimiko, Hara, Tomoyo, Sumitani, Ryohei, Maruhashi, Tomoko, Sebe, Mayu, Tsutsumi, Rie, Sakaue, Hiroshi, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro

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Therapeutic efficacy of the resorcylic acid lactone LL‐Z1640‐2 for adult T‐cell leukaemia/lymphoma von Oura, Masahiro, Harada, Takeshi, Oda, Asuka, Teramachi, Jumpei, Nakayama, Atsushi, Sumitani, Ryohei, Inoue, Yusuke, Maeda, Yusaku, Sogabe, Kimiko, Maruhashi, Tomoko, Takahashi, Mamiko, Fujii, Shiro, Nakamura, Shingen, Miki, Hirokazu, Nakamura, Masafumi, Hara, Tomoyo, Yamagami, Hiroki, Kurahashi, Kiyoe, Endo, Itsuro, Hasegawa, Hiroo, Fujiwara, Hiroshi, Abe, Masahiro

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Factors contributing to deep supercooling capability and cold survival in dwarf bamboo (Sasa senanensis) leaf blades von Ishikawa, Masaya, Oda, Asuka, Fukami, Reiko, Kuriyama, Akira

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Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors von Harada, Takeshi, Ozaki, Shuji, Oda, Asuka, Tsuji, Daisuke, Ikegame, Akishige, Iwasa, Masami, Udaka, Kengo, Fujii, Shiro, Nakamura, Shingen, Miki, Hirokazu, Kagawa, Kumiko, Kuroda, Yoshiaki, Kawai, Shigeto, Itoh, Kohji, Yamada-Okabe, Hisafumi, Matsumoto, Toshio, Abe, Masahiro

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Mechanical unloading enhances bone destruction and tumor expansion in multiple myeloma: Critical roles of osteocytic RANKL induction von Tanimoto, Kotaro, Hiasa, Masahiro, Tenshin, Hirofumi, Teramachi, Jumpei, Oda, Asuka, Harada, Takeshi, Ashter, Mohannad, Sogabe, Kimiko, Oura, Masahiro, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro

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TAK1 inhibition effectively suppresses NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis von Tenshin, Hirofumi, Teramachi, Jumpei, Hiasa, Masahiro, Oda, Asuka, Harada, Takeshi, Oura, Masahiro, Sogabe, Kimiko, Ashtar, Mohannad, Tanimoto, Kotaro, Shimizu, So, Higa, Yoshiki, Tanaka, Eiji, Matsumoto, Toshio, Abe, Masahiro

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The anti-SLAMF7 elotuzumab enhances ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells von Tenshin, Hirofumi, Harada, Takeshi, Inoue, Yusuke, Teramachi, Jumpei, Hiasa, Masahiro, Oda, Asuka, Tanimoto, Kotaro, Shimizu, So, Higa, Yoshiki, Oura, Masahiro, Sogabe, Kimiko, Hara, Tomoyo, Maruhashi, Tomoko, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro

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Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib von Nakamura, Shingen, Miki, Hirokazu, Kido, Shinsuke, Nakano, Ayako, Hiasa, Masahiro, Oda, Asuka, Amou, Hiroe, Watanabe, Keiichiro, Harada, Takeshi, Fujii, Shiro, Takeuchi, Kyoko, Kagawa, Kumiko, Ozaki, Shuji, Matsumoto, Toshio, Abe, Masahiro

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Inhibition of TACE activity enhances the susceptibility of myeloma cells to TRAIL von Kagawa, Kumiko, Nakano, Ayako, Miki, Hirokazu, Oda, Asuka, Amou, Hiroe, Takeuchi, Kyoko, Nakamura, Shingen, Harada, Takeshi, Fujii, Shiro, Yata, Kenichiro, Ozaki, Shuji, Matsumoto, Toshio, Abe, Masahiro

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Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma von Kitazoe, Ken-ichi, Abe, Masahiro, Hiasa, Masahiro, Oda, Asuka, Amou, Hiroe, Harada, Takeshi, Nakano, Ayako, Takeuchi, Kyoko, Hashimoto, Toshihiro, Ozaki, Shuji, Matsumoto, Toshio

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