Targeting the DNA Damage Response in Cancer von O’Connor, Mark J.

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity von Fok, Jacqueline H. L., Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W. G., Follia, Valeria, James, Neil, Farrington, Paul M., Karmokar, Ankur, Willis, Sophie E., Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M., Finlay, M. Raymond V., Wilson, Joanne, Smith, Aaron, O’Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E., O’Connor, Mark J., Hollingsworth, Simon J., Dean, Emma, Goldberg, Frederick W., Davies, Barry R., Cadogan, Elaine B.

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Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells von Dev, Harveer, Chiang, Ting-Wei Will, Lescale, Chloe, de Krijger, Inge, Martin, Alistair G., Pilger, Domenic, Coates, Julia, Sczaniecka-Clift, Matylda, Wei, Wenming, Ostermaier, Matthias, Herzog, Mareike, Lam, Jonathan, Shea, Abigail, Demir, Mukerrem, Wu, Qian, Yang, Fengtang, Fu, Beiyuan, Lai, Zhongwu, Balmus, Gabriel, Belotserkovskaya, Rimma, Serra, Violeta, O’Connor, Mark J., Bruna, Alejandra, Beli, Petra, Pellegrini, Luca, Caldas, Carlos, Deriano, Ludovic, Jacobs, Jacqueline J. L., Galanty, Yaron, Jackson, Stephen P.

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Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization von McCormick, Natalie, O’Connor, Mark J., Yokose, Chio, Merriman, Tony R., Mount, David B., Leong, Aaron, Choi, Hyon K.

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Targeting the replication stress response in cancer von Forment, Josep V., O’Connor, Mark J.

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Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes von Hodgson, Darren R., Dougherty, Brian A., Lai, Zhongwu, Fielding, Anitra, Grinsted, Lynda, Spencer, Stuart, O’Connor, Mark J., Ho, Tony W., Robertson, Jane D., Lanchbury, Jerry S., Timms, Kirsten M., Gutin, Alexander, Orr, Maria, Jones, Helen, Gilks, Blake, Womack, Chris, Gourley, Charlie, Ledermann, Jonathan, Barrett, J. Carl

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A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds von Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos

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SLFN11 informs on standard of care and novel treatments in a wide range of cancer models von Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta

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PARP Inhibitors: Extending Benefit Beyond BRCA -Mutant Cancers von Pilié, Patrick G, Gay, Carl M, Byers, Lauren A, O'Connor, Mark J, Yap, Timothy A

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency von Sun, Chaoyang, Yin, Jun, Fang, Yong, Chen, Jian, Jeong, Kang Jin, Chen, Xiaohua, Vellano, Christopher P., Ju, Zhenlin, Zhao, Wei, Zhang, Dong, Lu, Yiling, Meric-Bernstam, Funda, Yap, Timothy A., Hattersley, Maureen, O'Connor, Mark J., Chen, Huawei, Fawell, Stephen, Lin, Shiaw-Yih, Peng, Guang, Mills, Gordon B.

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ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1 von Moiseeva, Tatiana, Hood, Brian, Schamus, Sandy, O’Connor, Mark J., Conrads, Thomas P., Bakkenist, Christopher J.

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Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper von Illuzzi, Giuditta, Staniszewska, Anna D, Gill, Sonja J, Pike, Andy, McWilliams, Lisa, Critchlow, Susan E, Cronin, Anna, Fawell, Stephen, Hawthorne, Glen, Jamal, Kunzah, Johannes, Jeffrey, Leonard, Emilyanne, Macdonald, Ruth, Maglennon, Gareth, Nikkilä, Jenni, O'Connor, Mark J, Smith, Aaron, Southgate, Harriet, Wilson, Joanne, Yates, James, Cosulich, Sabina, Leo, Elisabetta

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Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models von Tran Chau, Vanessa, Liu, Winchygn, Gerbé de Thoré, Marine, Meziani, Lydia, Mondini, Michele, O’Connor, Mark J., Deutsch, Eric, Clémenson, Céline

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Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically von Riches, Lucy C, Trinidad, Antonio G, Hughes, Gareth, Jones, Gemma N, Hughes, Adina M, Thomason, Andrew G, Gavine, Paul, Cui, Andy, Ling, Stephanie, Stott, Jonathan, Clark, Roger, Peel, Samantha, Gill, Pendeep, Goodwin, Louise M, Smith, Aaron, Pike, Kurt G, Barlaam, Bernard, Pass, Martin, O'Connor, Mark J, Smith, Graeme, Cadogan, Elaine B

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Abstract 337: Genetic analysis of tumors from a phase II trial evaluating AZD1775, carboplatin and paclitaxel in patients with TP53-mutant ovarian cancer von Laing, Naomi, Lai, Zhongwu, Barrett, J. Carl, O’Connor, Mark J., Oza, Amit M., Lawrence, David

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Systolic and Diastolic Mechanics in Stress Cardiomyopathy von Medeiros, Keith, O’Connor, Mark J, Baicu, Catalin F, Fitzgibbons, Timothy P, Shaw, Peter, Tighe, Dennis A, Zile, Michael R, Aurigemma, Gerard P

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ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation von Vendetti, Frank P, Karukonda, Pooja, Clump, David A, Teo, Troy, Lalonde, Ronald, Nugent, Katriana, Ballew, Matthew, Kiesel, Brian F, Beumer, Jan H, Sarkar, Saumendra N, Conrads, Thomas P, O'Connor, Mark J, Ferris, Robert L, Tran, Phuoc T, Delgoffe, Greg M, Bakkenist, Christopher J

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Abstract 3721: A camptothecin-containing nanoparticle-drug conjugate combination with DDR agents provides a novel approach to increasing therapeutic index von Oplustil O’Connor, Lenka, Wang, Anderson T., Jones, David R., Odedra, Rajesh, Spreadborough, Michael, Wilson, Joanne, Smith, Aaron, Cotton, Peter, Reens, Jaimini, Barnes, Jen, Sheridan, Victoria, Eliasof, Scott, Tellez, Andres, Lau, Alan, Sadler, Claire, O’Connor, Mark J.

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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy von Fang, Yong, McGrail, Daniel J, Sun, Chaoyang, Labrie, Marilyne, Chen, Xiaohua, Zhang, Dong, Ju, Zhenlin, Vellano, Christopher P, Lu, Yiling, Li, Yongsheng, Jeong, Kang Jin, Ding, Zhiyong, Liang, Jiyong, Wang, Steven W, Dai, Hui, Lee, Sanghoon, Sahni, Nidhi, Mercado-Uribe, Imelda, Kim, Tae-Beom, Chen, Ken, Lin, Shiaw-Yih, Peng, Guang, Westin, Shannon N, Liu, Jinsong, O'Connor, Mark J, Yap, Timothy A, Mills, Gordon B

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The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo von Vendetti, Frank P, Lau, Alan, Schamus, Sandra, Conrads, Thomas P, O'Connor, Mark J, Bakkenist, Christopher J

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