3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies von Asada, Masaki, Iwahashi, Maki, Obitsu, Tetsuo, Kinoshita, Atsushi, Nakai, Yoshihiko, Onoda, Takahiro, Nagase, Toshihiko, Tanaka, Motoyuki, Yamaura, Yoshiyuki, Takizawa, Hiroya, Yoshikawa, Ken, Sato, Kazutoyo, Narita, Masami, Ohuchida, Shuichi, Nakai, Hisao, Toda, Masaaki

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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: Discovery and exploration of the carboxyamide side chain von Asada, Masaki, Obitsu, Tetsuo, Nagase, Toshihiko, Tanaka, Motoyuki, Yamaura, Yoshiyuki, Takizawa, Hiroya, Yoshikawa, Ken, Sato, Kazutoyo, Narita, Masami, Ohuchida, Shuichi, Nakai, Hisao, Toda, Masaaki

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Pyrazolo[1,5- a]pyrimidines, triazolo[1,5- a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF 1) receptor antagonists von Saito, Tetsuji, Obitsu, Tetsuo, Minamoto, Chiaki, Sugiura, Tsuneyuki, Matsumura, Naoya, Ueno, Sonoko, Kishi, Akihiro, Katsumata, Seishi, Nakai, Hisao, Toda, Masaaki

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Synthesis of the C17C27 fragment of bryostatin 3 von Obitsu, Tetsuo, Ohmori, Ken, Ogawa, Yasuyuki, Hosomi, Hiroyuki, Ohba, Shigeru, Nishiyama, Shigeru, Yamamura, Shosuke

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6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists von Saito, Tetsuji, Obitsu, Tetsuo, Kondo, Takashi, Matsui, Toshiaki, Nagao, Yuuki, Kusumi, Kensuke, Matsumura, Naoya, Ueno, Sonoko, Kishi, Akihiro, Katsumata, Seishi, Kagamiishi, Yoshifumi, Nakai, Hisao, Toda, Masaaki

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Total Synthesis of Bryostatin 3 von Ohmori, Ken, Ogawa, Yasuyuki, Obitsu, Tetsuo, Ishikawa, Yuichi, Nishiyama, Shigeru, Yamamura, Shosuke

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Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists von Sugimoto, Isamu, Kambe, Tohru, Okino, Tomotaka, Obitsu, Tetsuo, Ohta, Nobukazu, Nishiyama, Taihei, Kinoshita, Akihiro, Fujimoto, Taku, Egashira, Hiromu, Yamane, Shinsaku, Shuto, Satoshi, Tani, Kousuke, Maruyama, Toru

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Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF1) receptor antagonists von Saito, Tetsuji, Obitsu, Tetsuo, Kohno, Hiroshi, Sugimoto, Isamu, Matsushita, Takeshi, Nishiyama, Taihei, Hirota, Tomoko, Takeda, Hiroyuki, Matsumura, Naoya, Ueno, Sonoko, Kishi, Akihiro, Kagamiishi, Yoshifumi, Nakai, Hisao, Takaoka, Yoshikazu

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Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists von Asada, Masaki, Obitsu, Tetsuo, Kinoshita, Atsushi, Nakai, Yoshihiko, Nagase, Toshihiko, Sugimoto, Isamu, Tanaka, Motoyuki, Takizawa, Hiroya, Yoshikawa, Ken, Sato, Kazutoyo, Narita, Masami, Ohuchida, Shuichi, Nakai, Hisao, Toda, Masaaki

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Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF1) receptor antagonists: Symposium-in-Print: Chemic... von SAITO, Tetsuji, OBITSU, Tetsuo, KISHI, Akihiro, KAGAMIISHI, Yoshifumi, NAKAI, Hisao, TAKAOKA, Yoshikazu, KOHNO, Hiroshi, SUGIMOTO, Isamu, MATSUSHITA, Takeshi, NISHIYAMA, Taihei, HIROTA, Tomoko, TAKEDA, Hiroyuki, MATSUMURA, Naoya, UENO, Sonoko

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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically act... von Asada, Masaki, Obitsu, Tetsuo, Kinoshita, Atsushi, Nagase, Toshihiko, Yoshida, Tadahiro, Yamaura, Yoshiyuki, Takizawa, Hiroya, Yoshikawa, Ken, Sato, Kazutoyo, Narita, Masami, Nakai, Hisao, Toda, Masaaki, Tobe, Yoshito

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Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists von Asada, Masaki, Obitsu, Tetsuo, Nagase, Toshihiko, Sugimoto, Isamu, Yamaura, Yoshiyuki, Sato, Kazutoyo, Narita, Masami, Ohuchida, Shuichi, Nakai, Hisao, Toda, Masaaki

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Synthesis of the C 17C 27 fragment of bryostatin 3 von Obitsu, Tetsuo, Ohmori, Ken, Ogawa, Yasuyuki, Hosomi, Hiroyuki, Ohba, Shigeru, Nishiyama, Shigeru, Yamamura, Shosuke

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COMPOUND FOR TREATING CARTILAGE DISORDERS von TANI, Kousuke, NISHIURA, Akio, FUJIMURA, Shinsei, SUGIHARA, Hikaru, OBITSU, Tetsuo

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Compound for treating cartilage disorders von TANI KOUSUKE, OBITSU TETSUO, NISHIURA AKIO, FUJIMURA SHINSEI, SUGIHARA HIKARU

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Bicyclic heterocyclic compound von OBITSU TETSUO, SAITO TETSUJI, KAGAMIISHI YOSHIFUMI

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(−)-(3S)-4-(2-{[4,4-Di­methoxy-6-(benzyl­oxy­methyl)­per­hydro­pyran-2-yl]­methyl}-1,3-di­thian-2-yl)-4-methyl-3-(1,1,2,2-tetra­methyl-1-sila­propoxy)­pentan-1-ol von Hosomi, Hiroyuki, Ohba, Shigeru, Ohmori, Ken, Obitsu, Tetsuo, Ogawa, Yasuyuki, Ishikawa, Yuichi, Yamamura, Shosuke, Nishiyama, Shigeru

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COMPOUND FOR TREATING CARTILAGE DISORDERS von TANI, KOUSUKE, FUJIMURA, SHINSEI, OBITSU, TETSUO, SUGIHARA, HIKARU, NISHIURA, AKIO

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PREVENTIVE AND/OR THERAPEUTIC AGENT OF CARTILAGE DISORDER von OBITSU TETSUO, NISHIURA AKIO, FUJIMURA SHINSEI, SUGIHARA HIKARI, TANI KOSUKE

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COMPOUND FOR TREATING CARTILAGE DISORDERS von TANI, KOUSUKE, FUJIMURA, SHINSEI, OBITSU, TETSUO, SUGIHARA, HIKARU, NISHIURA, AKIO

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