A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk von Manning, Alisa, Highland, Heather M, Gasser, Jessica, Sim, Xueling, Tukiainen, Taru, Fontanillas, Pierre, Grarup, Niels, Rivas, Manuel A, Mahajan, Anubha, Locke, Adam E, Cingolani, Pablo, Pers, Tune H, Viñuela, Ana, Brown, Andrew A, Wu, Ying, Flannick, Jason, Fuchsberger, Christian, Gamazon, Eric R, Gaulton, Kyle J, Im, Hae Kyung, Teslovich, Tanya M, Blackwell, Thomas W, Bork-Jensen, Jette, Burtt, Noël P, Chen, Yuhui, Green, Todd, Hartl, Christopher, Kang, Hyun Min, Kumar, Ashish, Ladenvall, Claes, Ma, Clement, Moutsianas, Loukas, Pearson, Richard D, Perry, John R B, Rayner, N William, Robertson, Neil R, Scott, Laura J, van de Bunt, Martijn, Eriksson, Johan G, Jula, Antti, Koskinen, Seppo, Lehtimäki, Terho, Palotie, Aarno, Raitakari, Olli T, Jacobs, Suzanne B R, Wessel, Jennifer, Chu, Audrey Y, Scott, Robert A, Goodarzi, Mark O, Blancher, Christine, Buck, Gemma, Buck, David, Chines, Peter S, Gabriel, Stacey, Gjesing, Anette P, Groves, Christopher J, Hollensted, Mette, Huyghe, Jeroen R, Jackson, Anne U, Jun, Goo, Justesen, Johanne Marie, Mangino, Massimo, Murphy, Jacquelyn, Neville, Matt, Onofrio, Robert, Small, Kerrin S, Stringham, Heather M, Trakalo, Joseph, Banks, Eric, Carey, Jason, Carneiro, Mauricio O, DePristo, Mark, Farjoun, Yossi, Fennell, Timothy, Goldstein, Jacqueline I, Grant, George, Hrabé de Angelis, Martin, Maguire, Jared, Neale, Benjamin M, Poplin, Ryan, Purcell, Shaun, Schwarzmayr, Thomas, Shakir, Khalid, Smith, Joshua D, Strom, Tim M, Wieland, Thomas, Lindstrom, Jaana, Brandslund, Ivan, Christensen, Cramer, Surdulescu, Gabriela L, Lakka, Timo A, Doney, Alex S F, Nilsson, Peter, Wareham, Nicholas J, Langenberg, Claudia, Varga, Tibor V, Franks, Paul W, Rolandsson, Olov, Rosengren, Anders H, Farook, Vidya S

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Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls von Fuchsberger, Christian, Mahajan, Anubha, Agarwala, Vineeta, Caulkins, Lizz, Koesterer, Ryan, Sim, Xueling, Blackwell, Thomas W., Cingolani, Pablo, Locke, Adam E., Müller-Nurasyid, Martina, Grarup, Niels, Stringham, Heather M., Chen, Yuhui, Scott, Robert A., Below, Jennifer E., Parker, Stephen C. J., Green, Todd, Beer, Nicola L., Horikoshi, Momoko, Hu, Cheng, Maxwell, Taylor J., Nagai, Yoshihiko, Welch, Ryan P, Voight, Benjamin F., Han, Bok-Ghee, Jenkinson, Christopher P., Kuusisto, Johanna, Balkau, Beverley, Boeing, Heiner, Giedraitis, Vilmantas, Gottesman, Omri, Scott, James, Carey, Jason, Grant, George, Neale, Benjamin M., Purcell, Shaun, Butterworth, Adam S., Aung, Tin, Palli, Domenico, Curran, Joanne E., Rybin, Dennis, Farook, Vidya S., Kumar, Satish, Liu, Jianjun, Musani, Solomon K., Yengo, Loïc, Tan, Sian-Tsung, Wong, Tien Yin, Schwarzmayr, Thomas, Surdulescu, Gabriela L., Herder, Christian, Brandslund, Ivan, Koistinen, Heikki A., Farmer, Andrew J., Jørgensen, Marit E., Ladenvall, Claes, Linneberg, Allan, Orho-Melander, Marju, Qi, Qibin, Roden, Michael, Rolandsson, Olov, Rosengren, Anders H., Wood, Andrew R., Mihailov, Evelin, Blancher, Christine, Poplin, Ryan, Shakir, Khalid, DePristo, Mark, Deloukas, Panos, Nilsson, Peter, Isomaa, Bo, O'Rahilly, Stephen P., Pedersen, Oluf, Tuomilehto, Jaakko, Salomaa, Veikko, Syvänen, Ann-Christine, Bottinger, Erwin P., Chan, Juliana C. N., Chia, Kee Seng, Lehman, Donna M., Ma, Ronald C. W., Sandhu, Manjinder, Froguel, Philippe, Barroso, Inês, Glaser, Benjamin, Illig, Thomas, Prokopenko, Inga, Tuomi, Tiinamaija, Lee, Jong-Young, Morris, Andrew D., Hattersley, Andrew T., Collins, Francis S., Spector, Timothy D., Bell, Graeme I., McVean, Gilean, Hanis, Craig L., Frayling, Timothy M., Cox, Nancy J., Mohlke, Karen L., Groop, Leif

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The genetic architecture of type 2 diabetes von Flannick, Jason A, Mahajan, Anubha, Moutsianas, Loukas, Rivas, Manuel A, Blackwell, Thomas W, Robertson, Neil R, Rayner, N. William, Cingolani, Pablo, Locke, Adam E, Tajes, Juan Fernandez, Jackson, Anne U, Below, Jennifer E, Huang, Jinyan, Stitzel, Michael L, Varga, Tibor V, Hu, Cheng, Huh, Iksoo, Kim, Bong-Jo, Kim, Young Jin, Wang, Xu, Barzilai, Nir, Jenkinson, Christopher P, Kuulasmaa, Teemu, Kuusisto, Johanna, Manning, Alisa K, Palmer, Nicholette D, Giedraitis, Vilmantas, Purcell, Shaun, Lee, Heung Man, Lu, Yingchang, Saleheen, Danish, Aguilar, David Dominguez, Cheng, Ching-Yu, Correa, Adolfo, Fowler, Sharon P, Freedman, Barry I, Griswold, Michael, Hale, Daniel Esten, Khor, Chiea-Chuen, Lim, Wei Yen, Liu, Jianjun, van der Schouw, Yvonne T, Loh, Marie, Musani, Solomon K, Puppala, Sobha, Scott, William R, Mangino, Massimo, Bork-Jensen, Jette, Brandslund, Ivan, Koistinen, Heikki A, Jørgensen, Marit E, Jørgensen, Torben, Lannfelt, Lars, Narisu, Narisu, Milani, Lili, Neville, Matt, Orho-Melander, Marju, Qi, Lu, Roden, Michael, Swift, Amy, Wood, Andrew R, Mihailov, Evelin, Poplin, Ryan, Shakir, Khalid, Gjesing, Anette P, Jun, Goo, Murphy, Jacquelyn, Onofrio, Robert, Isomaa, Bo, Karpe, Fredrik, Huth, Cornelia, O’Rahilly, Stephen P, Watanabe, Richard M, Bharadwaj, Dwaipayan, Chia, Kee Seng, Ebrahim, Shah B, Pollin, Toni I, Froguel, Philippe, Teo, Yik Ying, Loos, Ruth J. F, DeFronzo, Ralph A, Glaser, Benjamin, Ingelsson, Erik, Im, Hae Kyung, Buck, Gemma, Lind, Lars, Farjoun, Yossi, Lee, Jong-Young, Donnelly, Peter, Laakso, Markku, Strom, Tim M, Blangero, John, Tai, E. Shyong, McVean, Gilean, Seielstad, Mark, Lander, Eric Steven, Abecasis, Goncalo, Florez, Jose Carlos, Kang, Hyun Min, Altshuler, David Matthew

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Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass von Girousse, Amandine, Tavernier, Geneviève, Valle, Carine, Moro, Cedric, Mejhert, Niklas, Dinel, Anne-Laure, Houssier, Marianne, Roussel, Balbine, Besse-Patin, Aurèle, Combes, Marion, Mir, Lucile, Monbrun, Laurent, Bézaire, Véronic, Prunet-Marcassus, Bénédicte, Waget, Aurélie, Vila, Isabelle, Caspar-Bauguil, Sylvie, Louche, Katie, Marques, Marie-Adeline, Mairal, Aline, Renoud, Marie-Laure, Galitzky, Jean, Holm, Cecilia, Mouisel, Etienne, Thalamas, Claire, Viguerie, Nathalie, Sulpice, Thierry, Burcelin, Rémy, Arner, Peter, Langin, Dominique

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The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells von Hassler, Justin R, Scheuner, Donalyn L, Wang, Shiyu, Han, Jaeseok, Kodali, Vamsi K, Li, Philip, Nguyen, Julie, George, Jenny S, Davis, Cory, Wu, Shengyang P, Bai, Yongsheng, Sartor, Maureen, Cavalcoli, James, Malhi, Harmeet, Baudouin, Gregory, Zhang, Yaoyang, Yates, III, John R, Itkin-Ansari, Pamela, Volkmann, Niels, Kaufman, Randal J

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The Hormonal Control of Food Intake von Coll, Anthony P., Farooqi, I. Sadaf, O'Rahilly, Stephen

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Modulation of Blood Pressure by Central Melanocortinergic Pathways von Greenfield, Jerry R, Miller, Jeffrey W, Keogh, Julia M, Henning, Elana, Satterwhite, Julie H, Cameron, Gregory S, Astruc, Beatrice, Mayer, John P, Brage, Soren, See, Teik Choon, Lomas, David J, O'Rahilly, Stephen, Farooqi, I. Sadaf

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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans von Patel, Satish, Alvarez-Guaita, Anna, Melvin, Audrey, Rimmington, Debra, Dattilo, Alessia, Miedzybrodzka, Emily L., Cimino, Irene, Maurin, Anne-Catherine, Roberts, Geoffrey P., Meek, Claire L., Virtue, Samuel, Sparks, Lauren M., Parsons, Stephanie A., Redman, Leanne M., Bray, George A., Liou, Alice P., Woods, Rachel M., Parry, Sion A., Jeppesen, Per B., Kolnes, Anders J., Harding, Heather P., Ron, David, Vidal-Puig, Antonio, Reimann, Frank, Gribble, Fiona M., Hulston, Carl J., Farooqi, I. Sadaf, Fafournoux, Pierre, Smith, Steven R., Jensen, Jorgen, Breen, Danna, Wu, Zhidan, Zhang, Bei B., Coll, Anthony P., Savage, David B., O’Rahilly, Stephen

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Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis von Christodoulides, C, Laudes, M, Cawthorn, W.P, Schinner, S, Soos, M, O'Rahilly, S, Sethi, J.K, Vidal-Puig, A

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Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells von Yang, Ming, Darwish, Tamana, Larraufie, Pierre, Rimmington, Debra, Cimino, Irene, Goldspink, Deborah A., Jenkins, Benjamin, Koulman, Albert, Brighton, Cheryl A., Ma, Marcella, Lam, Brian Y. H., Coll, Anthony P., O’Rahilly, Stephen, Reimann, Frank, Gribble, Fiona M.

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Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity von Asai, Masato, Ramachandrappa, Shwetha, Joachim, Maria, Shen, Yuan, Zhang, Rong, Nuthalapati, Nikhil, Ramanathan, Visali, Strochlic, David E., Ferket, Peter, Linhart, Kirsten, Ho, Caroline, Novoselova, Tatiana V., Garg, Sumedha, Ridderstråle, Martin, Marcus, Claude, Hirschhorn, Joel N., Keogh, Julia M., O'Rahilly, Stephen, Chan, Li F., Clark, Adrian J., Farooqi, I. Sadaf, Majzoub, Joseph A.

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Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing von Lam, Brian Y.H, Cimino, Irene, Polex-Wolf, Joseph, Nicole Kohnke, Sara, Rimmington, Debra, Iyemere, Valentine, Heeley, Nicholas, Cossetti, Chiara, Schulte, Reiner, Saraiva, Luis R, Logan, Darren W, Blouet, Clemence, O'Rahilly, Stephen, Coll, Anthony P, Yeo, Giles S.H

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GDF15 mediates the effects of metformin on body weight and energy balance von Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

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The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation von Boyle, K B, Hadaschik, D, Virtue, S, Cawthorn, W P, Ridley, S H, O'Rahilly, S, Siddle, K

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Adult onset global loss of the fto gene alters body composition and metabolism in the mouse von McMurray, Fiona, Church, Chris D, Larder, Rachel, Nicholson, George, Wells, Sara, Teboul, Lydia, Tung, Y C Loraine, Rimmington, Debra, Bosch, Fatima, Jimenez, Veronica, Yeo, Giles S H, O'Rahilly, Stephen, Ashcroft, Frances M, Coll, Anthony P, Cox, Roger D

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Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty von Duckett, Katie, Williamson, Alice, Kincaid, John W R, Rainbow, Kara, Corbin, Laura J, Martin, Hilary C, Eberhardt, Ruth Y, Huang, Qin Qin, Hurles, Matthew E, He, Wen, Brauner, Raja, Delaney, Angela, Dunkel, Leo, Grinspon, Romina P, Hall, Janet E, Hirschhorn, Joel N, Howard, Sasha R, Latronico, Ana C, Jorge, Alexander A L, McElreavey, Ken, Mericq, Verónica, Merino, Paulina M, Palmert, Mark R, Plummer, Lacey, Rey, Rodolfo A, Rezende, Raíssa C, Seminara, Stephanie B, Salnikov, Kathryn, Banerjee, Indraneel, Lam, Brian Y H, Perry, John R B, Timpson, Nicholas J, Clayton, Peter, Chan, Yee-Ming, Ong, Ken K, O’Rahilly, Stephen

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Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity von Liang, Zhengzheng S, Cimino, Irene, Yalcin, Binnaz, Raghupathy, Narayanan, Vancollie, Valerie E, Ibarra-Soria, Ximena, Firth, Helen V, Rimmington, Debra, Farooqi, I Sadaf, Lelliott, Christopher J, Munger, Steven C, O'Rahilly, Stephen, Ferguson-Smith, Anne C, Coll, Anthony P, Logan, Darren W

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Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats von Tung, Yi-Chun Loraine, Ayuso, Eduard, Shan, Xiaoye, Bosch, Fatima, O'Rahilly, Stephen, Coll, Anthony P, Yeo, Giles S.H

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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response von Mulderrig, Lee, Garaycoechea, Juan I., Tuong, Zewen K., Millington, Christopher L., Dingler, Felix A., Ferdinand, John R., Gaul, Liam, Tadross, John A., Arends, Mark J., O’Rahilly, Stephen, Crossan, Gerry P., Clatworthy, Menna R., Patel, Ketan J.

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Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function von Hawe, Johann S., Wilson, Rory, Schmid, Katharina T., Zhou, Li, Lakshmanan, Lakshmi Narayanan, Lehne, Benjamin C., Kühnel, Brigitte, Scott, William R., Wielscher, Matthias, Yew, Yik Weng, Baumbach, Clemens, Lee, Dominic P., Marouli, Eirini, Bernard, Manon, Pfeiffer, Liliane, Matías-García, Pamela R., Autio, Matias I., Bourgeois, Stephane, Herder, Christian, Karhunen, Ville, Meitinger, Thomas, Prokisch, Holger, Rathmann, Wolfgang, Roden, Michael, Sebert, Sylvain, Shin, Jean, Strauch, Konstantin, Zhang, Weihua, Tan, Wilson L. W., Hauck, Stefanie M., Merl-Pham, Juliane, Grallert, Harald, Barbosa, Eudes G. V., Illig, Thomas, Peters, Annette, Paus, Tomas, Pausova, Zdenka, Deloukas, Panos, Foo, Roger S. Y., Jarvelin, Marjo-Riitta, Kooner, Jaspal S., Loh, Marie, Heinig, Matthias, Gieger, Christian, Waldenberger, Melanie, Chambers, John C.

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