Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations von Vaz, Michelle, Hwang, Stephen Y., Kagiampakis, Ioannis, Phallen, Jillian, Patil, Ashwini, O'Hagan, Heather M., Murphy, Lauren, Zahnow, Cynthia A., Gabrielson, Edward, Velculescu, Victor E., Easwaran, Hariharan P., Baylin, Stephen B.

Volltext

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island von O'Hagan, Heather M, Mohammad, Helai P, Baylin, Stephen B

Volltext

Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy von DeStefano Shields, Christina E, White, James R, Chung, Liam, Wenzel, Alyssa, Hicks, Jessica L, Tam, Ada J, Chan, June L, Dejea, Christine M, Fan, Hongni, Michel, John, Maiuri, Ashley R, Sriramkumar, Shruthi, Podicheti, Ram, Rusch, Douglas B, Wang, Hao, De Marzo, Angelo M, Besharati, Sepideh, Anders, Robert A, Baylin, Stephen B, O'Hagan, Heather M, Housseau, Franck, Sears, Cynthia L

Volltext

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage von Ding, Ning, Bonham, Emily M, Hannon, Brooke E, Amick, Thomas R, Baylin, Stephen B, O'Hagan, Heather M

Volltext

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands von O'Hagan, Heather M., Wang, Wei, Sen, Subhojit, DeStefano Shields, Christina, Lee, Stella S., Zhang, Yang W., Clements, Eriko G., Cai, Yi, Van Neste, Leander, Easwaran, Hariharan, Casero, Robert A., Sears, Cynthia L., Baylin, Stephen B.

Volltext

RPA and ATR link transcriptional stress to p53 von Derheimer, Frederick A, O'Hagan, Heather M, Krueger, Heather M, Hanasoge, Sheela, Paulsen, Michelle T, Ljungman, Mats

Volltext

The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer von Savant, Sudha S, Sriramkumar, Shruthi, O'Hagan, Heather M

Volltext

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment von Sriramkumar, Shruthi, Metcalfe, Tara X, Lai, Tim, Zong, Xingyue, Fang, Fang, O'Hagan, Heather M, Nephew, Kenneth P

Volltext

Dietary antioxidants remodel DNA methylation patterns in chronic disease von Beetch, Megan, Harandi‐Zadeh, Sadaf, Shen, Kate, Lubecka, Katarzyna, Kitts, David D., O'Hagan, Heather M., Stefanska, Barbara

Volltext

Chromatin modifications during repair of environmental exposure-induced DNA damage: A potential mechanism for stable epigenetic alterations von O'Hagan, Heather M.

Volltext

PTEN depletion reduces H3K27me3 levels to promote epithelial-to-mesenchymal transition in epithelial colorectal cancer cells von Ghobashi, Ahmed H, Kimani, Jane W, Ladaika, Christopher A, O'Hagan, Heather M

Volltext

Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer von Sriramkumar, Shruthi, Sood, Riddhi, Huntington, Thomas D, Ghobashi, Ahmed H, Vuong, Truc T, Metcalfe, Tara X, Wang, Weini, Nephew, Kenneth P, O'Hagan, Heather M

Volltext

The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases von Ding, Ning, Maiuri, Ashley R., O’Hagan, Heather M.

Volltext

LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF -Mutant Colorectal Cancer von Miller, Samuel A, Policastro, Robert A, Sriramkumar, Shruthi, Lai, Tim, Huntington, Thomas D, Ladaika, Christopher A, Kim, Daeho, Hao, Chunhai, Zentner, Gabriel E, O'Hagan, Heather M

Volltext

How Epigenetic Therapy Beats Adverse Genetics in Monosomy Karyotype AML von O'Hagan, Heather M, Rassool, Feyruz V, Nephew, Kenneth P

Volltext

Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors von Ghobashi, Ahmed H, Lanzloth, Rosie, Ladaika, Christopher A, Masood, Ashiq, O'Hagan, Heather M

Volltext

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment von Shields, Christina E. DeStefano, Van Meerbeke, Sara W., Housseau, Franck, Wang, Hao, Huso, David L., Casero, Robert A., O'Hagan, Heather M., Sears, Cynthia L.

Volltext

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis von Maiuri, Ashley R, Peng, Michael, Sriramkumar, Shruthi, Kamplain, Caitlin M, DeStefano Shields, Christina E, Sears, Cynthia L, O'Hagan, Heather M

Volltext

Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR von Kang, Jae-Hyeok, Uddin, Nizam, Kim, Seungmo, Zhao, Yi, Yoo, Ki-Chun, Kim, Min-Jung, Hong, Sung-Ah, Bae, Sangsu, Lee, Jeong-Yeon, Shin, Incheol, Jin, Young Woo, O'Hagan, Heather M, Yi, Joo Mi, Lee, Su-Jae

Volltext

DVL regulation of tissue-specific aromatase transcripts in breast cancer von O'Hagan, Heather M

Volltext