The importance of p53 location: nuclear or cytoplasmic zip code? von O’Brate, Aurora, Giannakakou, Paraskevi

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OA21.05 Tepotinib + Osimertinib in EGFR-mutant NSCLC with MET Amplification Following 1L Osimertinib: INSIGHT 2 Primary Analysis von Kim, T.M., Guarneri, V., Jye, V.P., Khaw, L.B., Yang, J.-J., Wislez, M., Huang, C., Chong Kin, L., Mazieres, J., Tho, L.M., Hayashi, H., Nhung, N., Chia, P.L., De Marinis, F., Raskin, J., Zhou, Q., Finochhiaro, G., Le, X., Tan, D., Brutlach, S., O'Brate, A., Adrian, S., Berghoff, K., Ellers-Lenz, B., Karachaliou, N., Wu, Y.-L.

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PPD02.03 Tepotinib in Patients with MET Exon 14 (METex14) Skipping NSCLC: Analysis of All Patients From VISION Cohorts A and C von Garassino, M.C., Thomas, M., Felip, E., Sakai, H., Le, X., Veillon, R., Smit, E.F., Mazieres, J., Cortot, A.B., Raskin, J., Viteri, S., Chih-Hsin Yang, J., Ahn, M.-J., Wu, Y.-L., Ma, R., Zhao, J., O'Brate, A., Berghoff, K., Bruns, R., Otto, G., Paik, P.

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OA03.05 Tepotinib in Patients with MET Exon 14 (METex14) Skipping NSCLC: Primary Analysis of the Confirmatory VISION Cohort C von Thomas, M., Garassino, M., Felip, E., Sakai, H., Le, X., Veillon, R., Smit, E., Mazieres, J., Cortot, A., Raskin, J., Viteri, S., Yang, J.C.-H., Ahn, M.-J., Wu, Y.-L., Ma, R., Zhao, J., O'Brate, A., Berghoff, K., Bruns, R., Otto, G., Paik, P.

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Chemistry and Biology of Diazonamide A:  Second Total Synthesis and Biological Investigations von Nicolaou, K. C, Hao, Junliang, Reddy, Mali V, Rao, Paraselli Bheema, Rassias, Gerasimos, Snyder, Scott A, Huang, Xianhai, Chen, David Y.-K, Brenzovich, William E, Giuseppone, Nicolas, Giannakakou, Paraskevi, O'Brate, Aurora

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Enhanced Microtubule-Dependent Trafficking and p53 Nuclear Accumulation by Suppression of Microtubule Dynamics von Giannakakou, Paraskevi, Nakano, Michel, Nicolaou, Kyriacos C., O'Brate, Aurora, Yu, Jian, Blagosklonny, Mikhail V., Greber, Urs F., Fojo, Tito

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The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Acti... von Pryor, Donald E, O'Brate, Aurora, Bilcer, Geoffrey, Díaz, J. Fernando, Wang, Yuefang, Wang, Yong, Kabaki, Mikio, Jung, M. Katherine, Andreu, José M, Ghosh, Arun K, Giannakakou, Paraskevi, Hamel, Ernest

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The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase von MARCUS, Adam I, JUN ZHOU, O'BRATE, Aurora, HAMEL, Ernest, JASON WONG, NIVENS, Michael, EL-NAGGAR, Adel, YAO, Tso-Pang, KHURI, Fadlo R, GIANNAKAKOU, Paraskevi

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Paclitaxel Resistance in Non–Small-Cell Lung Cancer Associated With Beta-Tubulin Gene Mutations von Monzó, M, Rosell, R, Sánchez, J J, Lee, J S, O'Brate, A, González-Larriba, J L, Alberola, V, Lorenzo, J C, Núñez, L, Ro, J Y, Martín, C

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Discovery of a Biologically Active Thiostrepton Fragment von Nicolaou, K. C, Zak, Mark, Rahimipour, Shai, Estrada, Anthony A, Lee, Sang Hyup, O'Brate, Aurora, Giannakakou, Paraskevi, Ghadiri, M. Reza

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Total Synthesis of Apoptolidin:  Completion of the Synthesis and Analogue Synthesis and Evaluation von Nicolaou, K. C, Li, Yiwei, Sugita, Kazuyuki, Monenschein, Holger, Guntupalli, Prasuna, Mitchell, Helen J, Fylaktakidou, Konstantina C, Vourloumis, Dionisios, Giannakakou, Paraskevi, O'Brate, Aurora

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Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele von Wang, Yuefang, O'Brate, Aurora, Zhou, Wei, Giannakakou, Paraskevi

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Survivin deregulation in β-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to Taxol von ZHOU, Jun, O'BRATE, Aurora, ZELNAK, Amelia, GIANNAKAKOUL, Paraskevi

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Sharing New Approaches to Translational Research in Non‐Small Cell Lung Cancer von O'Brate, Aurora, Tarón, Miquel, Gandara, David, Rosell, Rafael

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Total Synthesis and Biological Evaluation of (−)Apicularen A and Analogues Thereof von Nicolaou, K. C., Kim, David W., Baati, Rachid, O′Brate, Aurora, Giannakakou, Paraskevi

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Design, Synthesis, and Biological Properties of Highly Potent Epothilone B Analogues von Nicolaou, K. C., Sasmal, Pradip K., Rassias, Gerasimos, Reddy, Mali Venkat, Altmann, Karl-Heinz, Wartmann, Markus, O'Brate, Aurora, Giannakakou, Paraskevi

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Studies toward Diazonamide A:  Development of a Hetero-Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure von Nicolaou, K. C, Snyder, Scott A, Giuseppone, Nicolas, Huang, Xianhai, Bella, Marco, Reddy, Mali V, Rao, Paraselli Bheema, Koumbis, Alexandros E, Giannakakou, Paraskevi, O'Brate, Aurora

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O-189 The combination of farnesyltransferase inhibitors and taxolreverses taxol resistance by enhancing taxol binding to microtubules: Clinical implications for NSCLC therapy von O'Brate, A., Marcus, A., Giannakakou, P.

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Chemical synthesis and biological evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues von Nicolaou, K.C, Ritzén, Andreas, Namoto, Kenji, Buey, Rubén M, Dı́az, J.Fernando, Andreu, José M, Wartmann, Markus, Altmann, Karl-Heinz, O'Brate, Aurora, Giannakakou, Paraskevi

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Predictive molecular markers in non–small cell lung cancer von Rosell, Rafael, Tarón, Miquel, O’Brate, Aurora

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