Computationally efficient whole-genome regression for quantitative and binary traits von Mbatchou, Joelle, Barnard, Leland, Backman, Joshua, Marcketta, Anthony, Kosmicki, Jack A., Ziyatdinov, Andrey, Benner, Christian, O’Dushlaine, Colm, Barber, Mathew, Boutkov, Boris, Habegger, Lukas, Ferreira, Manuel, Baras, Aris, Reid, Jeffrey, Abecasis, Goncalo, Maxwell, Evan, Marchini, Jonathan

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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease von Dewey, Frederick E, Gusarova, Viktoria, O’Dushlaine, Colm, Gottesman, Omri, Trejos, Jesus, Hunt, Charleen, Van Hout, Cristopher V, Habegger, Lukas, Buckler, David, Lai, Ka-Man V, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Ledbetter, David H, Penn, John, Lopez, Alexander, Borecki, Ingrid B, Overton, John D, Reid, Jeffrey G, Carey, David J, Murphy, Andrew J, Yancopoulos, George D, Baras, Aris, Gromada, Jesper, Shuldiner, Alan R

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INRICH: interval-based enrichment analysis for genome-wide association studies von LEE, Phil H, O'DUSHLAINE, Colm, THOMAS, Brett, PURCELL, Shaun M

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Genetic identification of familial hypercholesterolemia within a single U.S. health care system von Abul-Husn, Noura S., Manickam, Kandamurugu, Jones, Laney K., Wright, Eric A., Hartzel, Dustin N., Gonzaga-Jauregui, Claudia, O'Dushlaine, Colm, Leader, Joseph B., Kirchner, H. Lester, Lindbuchler, D'Andra M., Barr, Marci L., Giovanni, Monica A., Ritchie, Marylyn D., Overton, John D., Reid, Jeffrey G., Metpally, Raghu P. R., Wardeh, Amr H., Borecki, Ingrid B., Yancopoulos, George D., Baras, Aris, Shuldiner, Alan R., Gottesman, Omri, Ledbetter, David H., Carey, David J., Dewey, Frederick E., Murray, Michael F.

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Biobank-driven genomic discovery yields new insight into atrial fibrillation biology von Nielsen, Jonas B., Thorolfsdottir, Rosa B., Fritsche, Lars G., Zhou, Wei, Skov, Morten W., Graham, Sarah E., Herron, Todd J., McCarthy, Shane, Schmidt, Ellen M., Sveinbjornsson, Gardar, Surakka, Ida, Mathis, Michael R., Yamazaki, Masatoshi, Crawford, Ryan D., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Holmen, Oddgeir L., Lin, Maoxuan, Wolford, Brooke N., Dey, Rounak, Dalen, Håvard, Sulem, Patrick, Chung, Jonathan H., Backman, Joshua D., Arnar, David O., Thorsteinsdottir, Unnur, Baras, Aris, O’Dushlaine, Colm, Holst, Anders G., Wen, Xiaoquan, Hornsby, Whitney, Dewey, Frederick E., Boehnke, Michael, Kheterpal, Sachin, Mukherjee, Bhramar, Lee, Seunggeun, Kang, Hyun M., Holm, Hilma, Kitzman, Jacob, Shavit, Jordan A., Jalife, José, Brummett, Chad M., Teslovich, Tanya M., Carey, David J., Gudbjartsson, Daniel F., Stefansson, Kari, Abecasis, Gonçalo R., Hveem, Kristian, Willer, Cristen J.

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A polygenic burden of rare disruptive mutations in schizophrenia von Purcell, Shaun M., Moran, Jennifer L., Fromer, Menachem, Ruderfer, Douglas, Solovieff, Nadia, Roussos, Panos, O’Dushlaine, Colm, Chambert, Kimberly, Bergen, Sarah E., Kähler, Anna, Duncan, Laramie, Stahl, Eli, Genovese, Giulio, Fernández, Esperanza, Collins, Mark O., Komiyama, Noboru H., Choudhary, Jyoti S., Magnusson, Patrik K. E., Banks, Eric, Shakir, Khalid, Garimella, Kiran, Fennell, Tim, DePristo, Mark, Grant, Seth G. N., Haggarty, Stephen J., Gabriel, Stacey, Scolnick, Edward M., Lander, Eric S., Hultman, Christina M., Sullivan, Patrick F., McCarroll, Steven A., Sklar, Pamela

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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease von Abul-Husn, Noura S, Cheng, Xiping, Li, Alexander H, Xin, Yurong, Schurmann, Claudia, Stevis, Panayiotis, Liu, Yashu, Kozlitina, Julia, Stender, Stefan, Wood, G. Craig, Stepanchick, Ann N, Still, Matthew D, McCarthy, Shane, O’Dushlaine, Colm, Packer, Jonathan S, Balasubramanian, Suganthi, Gosalia, Nehal, Esopi, David, Kim, Sun Y, Mukherjee, Semanti, Lopez, Alexander E, Fuller, Erin D, Penn, John, Chu, Xin, Luo, Jonathan Z, Mirshahi, Uyenlinh L, Carey, David J, Still, Christopher D, Feldman, Michael D, Small, Aeron, Damrauer, Scott M, Rader, Daniel J, Zambrowicz, Brian, Olson, William, Murphy, Andrew J, Borecki, Ingrid B, Shuldiner, Alan R, Reid, Jeffrey G, Overton, John D, Yancopoulos, George D, Hobbs, Helen H, Cohen, Jonathan C, Gottesman, Omri, Teslovich, Tanya M, Baras, Aris, Mirshahi, Tooraj, Gromada, Jesper, Dewey, Frederick E

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Pathway analyses implicate glial cells in schizophrenia von Duncan, Laramie E, Holmans, Peter A, Lee, Phil H, O'Dushlaine, Colm T, Kirby, Andrew W, Smoller, Jordan W, Öngür, Dost, Cohen, Bruce M

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Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease von Horowitz, Julie E., Kosmicki, Jack A., Damask, Amy, Sharma, Deepika, Roberts, Genevieve H. L., Justice, Anne E., Banerjee, Nilanjana, Coignet, Marie V., Yadav, Ashish, Leader, Joseph B., Marcketta, Anthony, Park, Danny S., Lanche, Rouel, Maxwell, Evan, Knight, Spencer C., Bai, Xiaodong, Guturu, Harendra, Sun, Dylan, Baltzell, Asher, Kury, Fabricio S. P., Backman, Joshua D., Girshick, Ahna R., O’Dushlaine, Colm, McCurdy, Shannon R., Partha, Raghavendran, Mansfield, Adam J., Turissini, David A., Li, Alexander H., Zhang, Miao, Mbatchou, Joelle, Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Kang, Hyun M., Dobbyn, Lee, Stahl, Eli, Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Jones, Marcus, Balasubramanian, Suganthi, Siminovitch, Katherine, Salerno, William J., Shuldiner, Alan R., Rader, Daniel J., Mirshahi, Tooraj, Locke, Adam E., Marchini, Jonathan, Overton, John D., Carey, David J., Habegger, Lukas, Cantor, Michael N., Rand, Kristin A., Hong, Eurie L., Reid, Jeffrey G., Ball, Catherine A., Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.

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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR Study von Dewey, Frederick E.

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zCall: a rare variant caller for array-based genotyping von GOLDSTEIN, Jacqueline I, CRENSHAW, Andrew, SCHIZOPHRENIA CONSORTIUM, Swedish, SEQUENCING CONSORTIUM, Arra Autism, SKLAR, Pamela, HULTMAN, Christina M, PURCELL, Shaun, MCCARROLL, Steven A, SULLIVAN, Patrick F, DALY, Mark J, NEALE, Benjamin M, CAREY, Jason, GRANT, George B, MAGUIRE, Jared, FROMER, Menachem, O'DUSHLAINE, Colm, MORAN, Jennifer L, CHAMBERT, Kimberly, STEVENS, Christine

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Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility von O'Dushlaine, C, Kenny, E, Heron, E, Donohoe, G, Gill, M, Morris, D, Corvin, A

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Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease von Khera, Amit V, Won, Hong-Hee, Peloso, Gina M, O’Dushlaine, Colm, Liu, Dajiang, Stitziel, Nathan O, Natarajan, Pradeep, Nomura, Akihiro, Emdin, Connor A, Gupta, Namrata, Borecki, Ingrid B, Asselta, Rosanna, Duga, Stefano, Merlini, Piera Angelica, Correa, Adolfo, Kessler, Thorsten, Wilson, James G, Bown, Matthew J, Hall, Alistair S, Braund, Peter S, Carey, David J, Murray, Michael F, Kirchner, H. Lester, Leader, Joseph B, Lavage, Daniel R, Manus, J. Neil, Hartzel, Dustin N, Samani, Nilesh J, Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Lander, Eric S, Rader, Daniel J, Danesh, John, Ardissino, Diego, Gabriel, Stacey, Willer, Cristen, Abecasis, Gonçalo R, Saleheen, Danish, Dewey, Frederick E, Kathiresan, Sekar

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Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history von Bergen, Sarah E, O'Dushlaine, Colm T, Lee, Phil H, Fanous, Ayman H, Ruderfer, Douglas M, Ripke, Stephan, Sullivan, Patrick F, Smoller, Jordan W, Purcell, Shaun M, Corvin, Aiden

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Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder von O’Dushlaine, Colm, Ripke, Stephan, Ruderfer, Douglas M, Hamilton, Steven P, Fava, Maurizio, Iosifescu, Dan V, Kohane, Isaac S, Churchill, Susanne E, Castro, Victor M, Clements, Caitlin C, Blumenthal, Sarah R, Murphy, Shawn N, Smoller, Jordan W, Perlis, Roy H

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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder von Noh, Hyun Ji, Tang, Ruqi, Flannick, Jason, O’Dushlaine, Colm, Swofford, Ross, Howrigan, Daniel, Genereux, Diane P., Johnson, Jeremy, van Grootheest, Gerard, Grünblatt, Edna, Andersson, Erik, Djurfeldt, Diana R., Patel, Paresh D., Koltookian, Michele, M. Hultman, Christina, Pato, Michele T., Pato, Carlos N., Rasmussen, Steven A., Jenike, Michael A., Hanna, Gregory L., Stewart, S. Evelyn, Knowles, James A., Ruhrmann, Stephan, Grabe, Hans-Jörgen, Wagner, Michael, Rück, Christian, Mathews, Carol A., Walitza, Susanne, Cath, Daniëlle C., Feng, Guoping, Karlsson, Elinor K., Lindblad-Toh, Kerstin

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Population structure and genome-wide patterns of variation in Ireland and Britain von O'DUSHLAINE, Colm T, MORRIS, Derek, MOSKVINA, Valentina, KIROV, George, GILL, Michael, CORVIN, Aiden, WILSON, James F, CAVAHERI, Gianpiero L

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EmbedGEM: a framework to evaluate the utility of embeddings for genetic discovery von Mukherjee, Sumit, McCaw, Zachary R, Pei, Jingwen, Merkoulovitch, Anna, Soare, Tom, Tandon, Raghav, Amar, David, Somineni, Hari, Klein, Christoph, Satapati, Santhosh, Lloyd, David, Probert, Christopher, Koller, Daphne, O’Dushlaine, Colm, Karaletsos, Theofanis

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Implication of LRRC4C and DPP6 in neurodevelopmental disorders von Maussion, Gilles, Cruceanu, Cristiana, Rosenfeld, Jill A., Bell, Scott C., Jollant, Fabrice, Szatkiewicz, Jin, Collins, Ryan L., Hanscom, Carrie, Kolobova, Ilaria, de Champfleur, Nicolas Menjot, Blumenthal, Ian, Chiang, Colby, Ota, Vanessa, Hultman, Christina, O'Dushlaine, Colm, McCarroll, Steve, Alda, Martin, Jacquemont, Sebastien, Ordulu, Zehra, Marshall, Christian R., Carter, Melissa T., Shaffer, Lisa G., Sklar, Pamela, Girirajan, Santhosh, Morton, Cynthia C., Gusella, James F., Turecki, Gustavo, Stavropoulos, Dimitri J., Sullivan, Patrick F., Scherer, Stephen W., Talkowski, Michael E., Ernst, Carl

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Marked variation in predicted and observed variability of tandem repeat loci across the human genome von O'Dushlaine, Colm T, Shields, Denis C

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