Ketoreductase-Mediated Stereodivergent Synthesis of 1,1-Disubstituted Cyclobutan-3-ols von O’Dowd, Hardwin, Morales, Olivia M.

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Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives von O’Dowd, Hardwin, Manske, Jenna L., Freedman, Seth A., Cochran, John E.

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Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability von Grillot, Anne-Laure, Tiran, Arnaud Le, Shannon, Dean, Krueger, Elaine, Liao, Yusheng, O’Dowd, Hardwin, Tang, Qing, Ronkin, Steve, Wang, Tiansheng, Waal, Nathan, Li, Pan, Lauffer, David, Sizensky, Emmanuelle, Tanoury, Jerry, Perola, Emanuele, Grossman, Trudy H, Doyle, Tim, Hanzelka, Brian, Jones, Steven, Dixit, Vaishali, Ewing, Nigel, Liao, Shengkai, Boucher, Brian, Jacobs, Marc, Bennani, Youssef, Charifson, Paul S

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of M... von Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M

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Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1 von Boyd, Michael J, Collier, Philip N, Clark, Michael P, Deng, Hongbo, Kesavan, Sarathy, Ronkin, Steven M, Waal, Nathan, Wang, Jian, Cao, Jingrong, Li, Pan, Come, Jon, Davies, Ioana, Duffy, John P, Cochran, John E, Court, John J, Chandupatla, Kishan, Jackson, Katrina L, Maltais, Francois, O’Dowd, Hardwin, Boucher, Christina, Considine, Tony, Taylor, William P, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Crawford, Dan, Doyle, Elizabeth, Phillips, Jonathan, Kemper, Raymond, Swett, Rebecca, Empfield, James, Bunnage, Mark E, Charifson, Paul S, Magavi, Sanjay Shivayogi

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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1 von Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S

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Antimalarial, Antiproliferative, and Antitumor Activities of Artemisinin-Derived, Chemically Robust, Trioxane Dimers von Posner, Gary H, Ploypradith, Poonsakdi, Parker, Michael H, O'Dowd, Hardwin, Woo, Soon-Hyung, Northrop, John, Krasavin, Mikhail, Dolan, Patrick, Kensler, Thomas W, Xie, Suji, Shapiro, Theresa A

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Synthesis of a 6‑Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3‑Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization von Collier, Philip N, Panchagnula, Advaita, O’Dowd, Hardwin, Le Tiran, Arnaud, Aronov, Alex M

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Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones von Wang, Tiansheng, Duncan, Leonard, Gu, Wenxin, O’Dowd, Hardwin, Wei, Yunyi, Perola, Emanuele, Parsons, Jonathan, Gross, Christian H., Moody, Cameron Stuver, Ryan Arends, S.J., Charifson, Paul S.

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N- and C-terminal modifications of negamycin von Raju, B, Mortell, Kathleen, Anandan, Sampathkumar, O'Dowd, Hardwin, Gao, Hongwu, Gomez, Marcela, Hackbarth, Corinne, Wu, Charlotte, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim, Patel, Dinesh V

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An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-Carboxylate Derivatives von Wishka, Donn G, Bédard, Marion, Brighty, Katherine E, Buzon, Richard A, Farley, Kathleen A, Fichtner, Michael W, Kauffman, Goss S, Kooistra, Jaap, Lewis, Jason G, O’Dowd, Hardwin, Samardjiev, Ivan J, Samas, Brian, Yalamanchi, Geeta, Noe, Mark C

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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV von O’Dowd, Hardwin, Shannon, Dean E, Chandupatla, Kishan R, Dixit, Vaishali, Engtrakul, Juntyma J, Ye, Zhengqi, Jones, Steven M, O’Brien, Colleen F, Nicolau, David P, Tessier, Pamela R, Crandon, Jared L, Song, Bin, Macikenas, Dainius, Hanzelka, Brian L, Le Tiran, Arnaud, Bennani, Youssef L, Charifson, Paul S, Grillot, Anne-Laure

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Enantioselective Synthesis of N1999A2 von Ji, Nan, O'Dowd, Hardwin, Rosen, Brad M, Myers, Andrew G

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Novel antibacterial azetidine lincosamides von O’Dowd, Hardwin, Lewis, Jason G., Trias, Joaquim, Asano, Rumi, Blais, Johanne, Lopez, Sara L., Park, Craig K., Wu, Charlotte, Wang, Wen, Gordeev, Mikhail F.

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Preparation of tetra-Boc-protected polymyxin B nonapeptide von O’Dowd, Hardwin, Kim, Bum, Margolis, Peter, Wang, Wen, Wu, Charlotte, Lopez, Sara L., Blais, Johanne

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Novel 6-position modified 1-thioalkyl-lincosamines von O’Dowd, Hardwin, Lewis, Jason G., Gordeev, Mikhail F.

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Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part II: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones von TIANSHENG WANG, DUNCAN, Leonard, CHARIFSON, Paul S, WENXIN GU, O'DOWD, Hardwin, YUNYI WEI, PEROLA, Emanuele, PARSONS, Jonathan, GROSS, Christian H, CAMERON STUVER MOODY, RYAN ARENDS, S. J

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Conformationally restricted analogs of deoxynegamycin von Raju, B., Anandan, Sampathkumar, Gu, Shihai, Herradura, Prudencio, O’Dowd, Hardwin, Kim, Bum, Gomez, Marcela, Hackbarth, Corinne, Wu, Charlotte, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim, Patel, Dinesh V.

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A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA von GREEN, JEREMY, BOYD, MICHAEL JOHN, ARONOV, ALEX, O'DOWD, HARDWIN

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Antimalarial Cyclic Peroxy Ketals von Posner, Gary H, O'Dowd, Hardwin, Ploypradith, Poonsakdi, Cumming, Jared N, Xie, Suji, Shapiro, Theresa A

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