The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens von Gray, Daniel H.D., Kupresanin, Fiona, Berzins, Stuart P., Herold, Marco J., O'Reilly, Lorraine A., Bouillet, Philippe, Strasser, Andreas

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Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis von Teh, Charis E., Lalaoui, Najoua, Jain, Reema, Policheni, Antonia N., Heinlein, Melanie, Alvarez-Diaz, Silvia, Sheridan, Julie M., Rieser, Eva, Deuser, Stefanie, Darding, Maurice, Koay, Hui-Fern, Hu, Yifang, Kupresanin, Fiona, O’Reilly, Lorraine A., Godfrey, Dale I., Smyth, Gordon K., Bouillet, Philippe, Strasser, Andreas, Walczak, Henning, Silke, John, Gray, Daniel H. D.

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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function von Schoenwaelder, Simone M., Yuan, Yuping, Josefsson, Emma C., White, Michael J., Yao, Yu, Mason, Kylie D., O'Reilly, Lorraine A., Henley, Katya J., Ono, Akiko, Hsiao, Sarah, Willcox, Abbey, Roberts, Andrew W., Huang, David C.S., Salem, Hatem H., Kile, Benjamin T., Jackson, Shaun P.

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Patient and public involvement in preclinical and medical research: Evaluation of an established programme in a Discovery‐Based Medical Research Institute von Smith, Robyn A., Slocombe, Judith, Cockwill, Jo, Minas, Kathy, Kiossoglou, George, Gray, Katya, Lawrence, William, Iddles, Michelle, Scott, Clare, O'Reilly, Lorraine A.

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role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins von Mérino, Delphine, Giam, Maybelline, Hughes, Peter D, Siggs, Owen M, Heger, Klaus, O'Reilly, Lorraine A, Adams, Jerry M, Strasser, Andreas, Lee, Erinna F, Fairlie, Walter D, Bouillet, Philippe

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Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1 von Croker, Ben A, O'Donnell, Joanne A, Nowell, Cameron J, Metcalf, Donald, Dewson, Grant, Campbell, Kirsteen J, Rogers, Kelly L, Hu, Yifang, Smyth, Gordon K, Zhang, Jian-Guo, White, Michael, Lackovic, Kurt, Cengia, Louise H, O'Reilly, Lorraine A, Bouillet, Philippe, Cory, Suzanne, Strasser, Andreas, Roberts, Andrew W

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome von Strasser, Andreas, Marsden, Vanessa S, O'Connor, Liam, O'Reilly, Lorraine A, Silke, John, Metcalf, Donald, Ekert, Paul G, Huang, David C. S, Cecconi, Francesco, Kuida, Keisuke, Tomaselli, Kevin J, Roy, Sophie, Nicholson, Don W, Vaux, David L, Bouillet, Philippe, Adams, Jerry M

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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis von Alvarez-Diaz, Silvia, Dillon, Christopher P., Lalaoui, Najoua, Tanzer, Maria C., Rodriguez, Diego A., Lin, Ann, Lebois, Marion, Hakem, Razq, Josefsson, Emma C., O’Reilly, Lorraine A., Silke, John, Alexander, Warren S., Green, Douglas R., Strasser, Andreas

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CD95, BIM and T cell homeostasis von Bouillet, Philippe, O'Reilly, Lorraine A

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MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation von O'Reilly, Lorraine A, Kruse, Elizabeth A, Puthalakath, Hamsa, Kelly, Priscilla N, Kaufmann, Thomas, Huang, David C. S, Strasser, Andreas

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Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis von Salvamoser, Ranja, Brinkmann, Kerstin, O’Reilly, Lorraine A., Whitehead, Lachlan, Strasser, Andreas, Herold, Marco J.

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A type III effector antagonizes death receptor signalling during bacterial gut infection von Pearson, Jaclyn S., Giogha, Cristina, Ong, Sze Ying, Kennedy, Catherine L., Kelly, Michelle, Robinson, Keith S., Lung, Tania Wong Fok, Mansell, Ashley, Riedmaier, Patrice, Oates, Clare V. L., Zaid, Ali, Mühlen, Sabrina, Crepin, Valerie F., Marches, Olivier, Ang, Ching-Seng, Williamson, Nicholas A., O’Reilly, Lorraine A., Bankovacki, Aleksandra, Nachbur, Ueli, Infusini, Giuseppe, Webb, Andrew I., Silke, John, Strasser, Andreas, Frankel, Gad, Hartland, Elizabeth L.

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming von Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E

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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity von Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O’Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

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Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers von Ni, Yanhong, Low, Jun T, Silke, John, O'Reilly, Lorraine A

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Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells von Naik, Edwina, O'Reilly, Lorraine A, Asselin-Labat, Marie-Liesse, Merino, Delphine, Lin, Ann, Cook, Michele, Coultas, Leigh, Bouillet, Philippe, Adams, Jerry M, Strasser, Andreas

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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function von Item, Flurin, Wueest, Stephan, Lemos, Vera, Stein, Sokrates, Lucchini, Fabrizio C., Denzler, Rémy, Fisser, Muriel C., Challa, Tenagne D., Pirinen, Eija, Kim, Youngsoo, Hemmi, Silvio, Gulbins, Erich, Gross, Atan, O’Reilly, Lorraine A., Stoffel, Markus, Auwerx, Johan, Konrad, Daniel

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Transforming Growth Factor β-Dependent Sequential Activation of Smad, Bim, and Caspase-9 Mediates Physiological Apoptosis in Gastric Epithelial Cells von Ohgushi, Masatoshi, Kuroki, Shunsuke, Fukamachi, Hiroshi, O'Reilly, Lorraine A., Kuida, Keisuke, Strasser, Andreas, Yonehara, Shin

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Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner von O’Reilly, Lorraine A., Putoczki, Tracy L., Mielke, Lisa A., Low, Jun T., Lin, Ann, Preaudet, Adele, Herold, Marco J., Yaprianto, Kelvin, Tai, Lin, Kueh, Andrew, Pacini, Guido, Ferrero, Richard L., Gugasyan, Raffi, Hu, Yifang, Christie, Michael, Wilcox, Stephen, Grumont, Raelene, Griffin, Michael D.W., O’Connor, Liam, Smyth, Gordon K., Ernst, Mathias, Waring, Paul, Gerondakis, Steve, Strasser, Andreas

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OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling von Ding, Liang, Fu, Yong, Zhu, Nisha, Zhao, Mengxiang, Ding, Zhuang, Zhang, Xiaoxin, Song, Yuxian, Jing, Yue, Zhang, Qian, Chen, Sheng, Huang, Xiaofeng, O’Reilly, Lorraine A, Silke, John, Hu, Qingang, Ni, Yanhong

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