Conformational Abs Recognizing a Generic Amyloid Fibril Epitope von O'Nuallain, Brian, Wetzel, Ronald

Volltext

Seeding Specificity in Amyloid Growth Induced by Heterologous Fibrils von O'Nuallain, Brian, Williams, Angela D., Westermark, Per, Wetzel, Ronald

Volltext

IgG Conformer's Binding to Amyloidogenic Aggregates von Phay, Monichan, Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Blinder, Veronika, O'Malley, Tiernan T, Solomon, Alan, Walsh, Dominic M, O'Nuallain, Brian

Volltext

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites von Tokarew, Jacqueline M., El-Kodsi, Daniel N., Lengacher, Nathalie A., Fehr, Travis K., Nguyen, Angela P., Shutinoski, Bojan, O’Nuallain, Brian, Jin, Ming, Khan, Jasmine M., Ng, Andy C. H., Li, Juan, Jiang, Qiubo, Zhang, Mei, Wang, Liqun, Sengupta, Rajib, Barber, Kathryn R., Tran, An, Im, Doo Soon, Callaghan, Steve, Park, David S., Zandee, Stephanie, Dong, Xiajun, Scherzer, Clemens R., Prat, Alexandre, Tsai, Eve C., Takanashi, Masashi, Hattori, Nobutaka, Chan, Jennifer A., Zecca, Luigi, West, Andrew B., Holmgren, Arne, Puente, Lawrence, Shaw, Gary S., Toth, Gergely, Woulfe, John M., Taylor, Peggy, Tomlinson, Julianna J., Schlossmacher, Michael G.

Volltext

Transthyretin Aggregate-Specific Antibodies Recognize Cryptic Epitopes on Patient-Derived Amyloid Fibrils von Phay, Monichan, Blinder, Veronika, Macy, Sallie, Greene, Michael J., Wooliver, Daniel C., Liu, Wen, Planas, Antoni, Walsh, Dominic M., Connors, Lawreen H., Primmer, Stanley R., Planque, Stephanie A., Paul, Sudhir, O'Nuallain, Brian

Volltext

Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth von Novobrantseva, Tatiana, Manfra, Denise, Ritter, Jessica, Razlog, Maja, O'Nuallain, Brian, Zafari, Mohammad, Nowakowska, Dominika, Basinski, Sara, Phennicie, Ryan T, Nguyen, Phuong A, Brehm, Michael A, Sazinsky, Stephen, Feldman, Igor

Volltext

Effector function of anti-pyroglutamate-3 A beta antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice von Crehan, Helen, Liu, Bin, Kleinschmidt, Martin, Rahfeld, Jens-Ulrich, Le, Kevin X., Caldarone, Barbara J., Frost, Jeffrey L., Hettmann, Thore, Hutter-Paier, Birgit, O'Nuallain, Brian, Park, Mi-Ae, DiCarli, Marcelo F., Lues, Inge, Schilling, Stephan, Lemere, Cynthia A.

Volltext

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils von O'Nuallain, Brian, Freir, Darragh B, Nicoll, Andrew J, Risse, Emmanuel, Ferguson, Neil, Herron, Caroline E, Collinge, John, Walsh, Dominic M

Volltext

Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide von Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A, Ehrlich, Hartmut J, Schwarz, Hans P, Walsh, Dominic M, Solomon, Alan, O'Nuallain, Brian

Volltext

Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, lea... von Nguyen, Ani, Ritter, Jessica, Zafari, Mohammad, Manfra, Denise, Komoroski, Veronica, O'Nuallain, Brian, Phennicie, Ryan, Kauffman, Kevin, Nowakowska, Dominika, Wahle, Joe, Sazinsky, Steve, Brehm, Michael, Feldman, Igor, Novobrantseva, Tatiana

Volltext

A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo von Levites, Yona, O'Nuallain, Brian, Puligedda, Rama Devudu, Ondrejcak, Tomas, Adekar, Sharad P, Chen, Cindy, Cruz, Pedro E, Rosario, Awilda M, Macy, Sallie, Mably, Alexandra J, Walsh, Dominic M, Vidal, Ruben, Solomon, Alan, Brown, Daniel, Rowan, Michael J, Golde, Todd E, Dessain, Scott K

Volltext

An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice von Frost, Jeffrey L, Liu, Bin, Rahfeld, Jens-Ulrich, Kleinschmidt, Martin, O'Nuallain, Brian, Le, Kevin X, Lues, Inge, Caldarone, Barbara J, Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A

Volltext

Specific Amyloid β Clearance by a Catalytic Antibody Construct von Planque, Stephanie A., Nishiyama, Yasuhiro, Sonoda, Sari, Lin, Yan, Taguchi, Hiroaki, Hara, Mariko, Kolodziej, Steven, Mitsuda, Yukie, Gonzalez, Veronica, Sait, Hameetha B.R., Fukuchi, Ken-ichiro, Massey, Richard J., Friedland, Robert P., O'Nuallain, Brian, Sigurdsson, Einar M., Paul, Sudhir

Volltext

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ von O’Nuallain, Brian, Klyubin, Igor, Mc Donald, Jessica M., Foster, James S., Welzel, Alfred, Barry, Andrew, Dykoski, Richard K., Cleary, James P., Gebbink, Martijn F.B.G., Rowan, Michael J., Walsh, Dominic M.

Volltext

Tau immunization: a cautionary tale? von Mably, Alexandra J, Kanmert, Daniel, Mc Donald, Jessica M, Liu, Wen, Caldarone, Barbara J, Lemere, Cynthia A, O'Nuallain, Brian, Kosik, Kenneth S, Walsh, Dominic M

Volltext

PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages von Kauffman, Kevin, Manfra, Denise, Nowakowska, Dominika, Zafari, Mohammad, Nguyen, Phuong A., Phennicie, Ryan, Vollmann, Elisabeth H., O'Nuallain, Brian, Basinski, Sara, Komoroski, Veronica, Rooney, Kate, Culyba, Elizabeth K., Wahle, Joseph, Ries, Carola, Brehm, Michael, Sazinsky, Steve, Feldman, Igor, Novobrantseva, Tatiana I.

Volltext

Intranasal immunization with 3A1 antibody reduced cerebral beta-amyloid multimers in 5XFAD mice von Chauhan, Neelima, Davis, Francesca, Xiao, Chun, O'Nuallain, Brian, Lemere, Cynthia

Volltext

Phage Display and Peptide Mapping of an Immunoglobulin Light Chain Fibril-Related Conformational Epitope von O'Nuallain, Brian, Allen, Amy, Ataman, Demet, Weiss, Deborah T, Solomon, Alan, Wall, Jonathan S

Volltext

ARE ANTI-ABETA AGGREGATE-PREFERRING ANTIBODIES THE FUTURE FOR AD IMMUNOTHERAPY? von O'Nuallain, Brian, Blinder, Veronika, Kanmert, Daniel, O'Malley, Tiernan, Mably, Alexandra, Frost, Jeffrey, Vanderburgh, Charles R, Lemere, Cynthia A, Walsh, Dominic

Volltext

P4–343: A naturally occurring human IgG specific for oligomeric and fibrillar beta‐amyloid: In vitro and in vivo studies von Devudu Puligedda, Rama, Levites, Yona, O'Nuallain, Brian, Ondrejcak, Tomas, Cruz, Pedro, Ladd, Thomas, Rowan, Michael, Dessain, Scott

Volltext