Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias von Cortes, Jorge E, Kantarjian, Hagop, Shah, Neil P, Bixby, Dale, Mauro, Michael J, Flinn, Ian, O'Hare, Thomas, Hu, Simin, Narasimhan, Narayana I, Rivera, Victor M, Clackson, Tim, Turner, Christopher D, Haluska, Frank G, Druker, Brian J, Deininger, Michael W.N, Talpaz, Moshe

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AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance von O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

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Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl von Gregory, Mark A, Phang, Tzu L, Neviani, Paolo, Alvarez-Calderon, Francesca, Eide, Christopher A, O'Hare, Thomas, Zaberezhnyy, Vadym, Williams, Richard T, Druker, Brian J, Perrotti, Danilo, Degregori, James

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Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening von TYNER, Jeffrey W, YANG, Wayne F, KOVACSOVICS, Tibor, GOTLIB, Jason R, OH, Stephen T, DEININGER, Michael W, MICHEL ZWAAN, Christian, DEN BOER, Monique L, VAN DEN HEUVEL-EIBRINK, Marry M, O'HARE, Thomas, DRUKER, Brian J, LORIAUX, Marc M, BANKHEAD, Armand, GUANG FAN, FLETCHER, Luke B, BRYANT, Jade, GLOVER, Jason M, CHANG, Bill H, SPURGEON, Stephen E, FLEMING, William H

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BCR-ABL1 compound mutations in tyrosine kinase inhibitor–resistant CML: frequency and clonal relationships von Khorashad, Jamshid S., Kelley, Todd W., Szankasi, Philippe, Mason, Clinton C., Soverini, Simona, Adrian, Lauren T., Eide, Christopher A., Zabriskie, Matthew S., Lange, Thoralf, Estrada, Johanna C., Pomicter, Anthony D., Eiring, Anna M., Kraft, Ira L., Anderson, David J., Gu, Zhimin, Alikian, Mary, Reid, Alistair G., Foroni, Letizia, Marin, David, Druker, Brian J., O'Hare, Thomas, Deininger, Michael W.

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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants von O'HARE, Thomas, WALTERS, Denise K, DRUKER, Brian J, STOFFREGEN, Eric P, TAIPING JIA, MANLEY, Paul W, MESTAN, Jürgen, COWAN-JACOB, Sandra W, LEE, Francis Y, HEINRICH, Michael C, DEININGER, Michael W. N

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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

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Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia von Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard

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Activating alleles of JAK3 in acute megakaryoblastic leukemia von Walters, Denise K., Mercher, Thomas, Gu, Ting-Lei, O'Hare, Thomas, Tyner, Jeffrey W., Loriaux, Marc, Goss, Valerie L., Lee, Kimberly A., Eide, Christopher A., Wong, Matthew J., Stoffregen, Eric P., McGreevey, Laura, Nardone, Julie, Moore, Sandra A., Crispino, John, Boggon, Titus J., Heinrich, Michael C., Deininger, Michael W., Polakiewicz, Roberto D., Gilliland, D. Gary, Druker, Brian J.

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An illicit economy: Scavenging and recycling of medical waste von Patwary, Masum A., O’Hare, William Thomas, Sarker, M.H.

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Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib von Griswold, Ian J., MacPartlin, Mary, Bumm, Thomas, Goss, Valerie L., O'Hare, Thomas, Lee, Kimberly A., Corbin, Amie S., Stoffregen, Eric P., Smith, Caitlyn, Johnson, Kara, Moseson, Erika M., Wood, Lisa J., Polakiewicz, Roberto D., Druker, Brian J., Deininger, Michael W.

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A Decade of Nilotinib and Dasatinib: From In Vitro Studies to First-Line Tyrosine Kinase Inhibitors von O'Hare, Thomas

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JAK2ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera von Patel, Ami B., Franzini, Anca, Leroy, Emilie, Kim, Soo Jin, Pomicter, Anthony D., Genet, Lidvine, Xiao, Michael, Yan, Dongqing, Ahmann, Jonathan M., Agarwal, Archana M., Clair, Phillip, Addada, Juanah, Lambert, Jonathan, Salmon, Matthew, Gleich, Gerald J., Cross, Nicholas C.P., Constantinescu, Stefan N., O'Hare, Thomas, Prchal, Josef T., Deininger, Michael W.

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Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

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Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy von Buetti-Dinh, Antoine, O'Hare, Thomas, Friedman, Ran

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RNAi screen for rapid therapeutic target identification in leukemia patients von Tyner, Jeffrey W, Deininger, Michael W, Loriaux, Marc M, Chang, Bill H, Gotlib, Jason R, Willis, Stephanie G, Erickson, Heidi, Kovacsovics, Tibor, O'Hare, Thomas, Heinrich, Michael C, Druker, Brian J

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Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting von Jacob, Thomas, Agarwal, Anupriya, Ramunno-Johnson, Damien, O’Hare, Thomas, Gönen, Mehmet, Tyner, Jeffrey W., Druker, Brian J., Vu, Tania Q.

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Abstinence self-efficacy in people with severe mental illness von O'Hare, Thomas, Ph.D, Shen, Ce, Ph.D

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Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells von Pomicter, Anthony D., Clair, Phillip M., Yan, Dongqing, Heaton, William L., Eiring, Anna M., Anderson, Michael B., Richards, Stephen M., Gililland, Jeremy, O’Hare, Thomas, Deininger, Michael W.

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Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion von Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.

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