Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses von O'Flanagan, Ciara H, Campbell, Kieran R, Zhang, Allen W, Kabeer, Farhia, Lim, Jamie L P, Biele, Justina, Eirew, Peter, Lai, Daniel, McPherson, Andrew, Kong, Esther, Bates, Cherie, Borkowski, Kelly, Wiens, Matt, Hewitson, Brittany, Hopkins, James, Pham, Jenifer, Ceglia, Nicholas, Moore, Richard, Mungall, Andrew J, McAlpine, Jessica N, Shah, Sohrab P, Aparicio, Samuel

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When less may be more: calorie restriction and response to cancer therapy von O'Flanagan, Ciara H, Smith, Laura A, McDonell, Shannon B, Hursting, Stephen D

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PINK1 signalling in cancer biology von O'Flanagan, Ciara H., O'Neill, Cora

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Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells von Lyons, Amy, Coleman, Michael, Riis, Sarah, Favre, Cedric, O'Flanagan, Ciara H., Zhdanov, Alexander V., Papkovsky, Dmitri B., Hursting, Stephen D., O'Connor, Rosemary

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Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs von Cui, Yi, Yang, Gaojie, Goodwin, Daniel R, O'Flanagan, Ciara H, Sinha, Anubhav, Zhang, Chi, Kitko, Kristina E, Shin, Tay Won, Park, Demian, Aparicio, Samuel, Boyden, Edward S

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Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction von Coleman, Michael F, O’Flanagan, Ciara H, Pfeil, Alexander J, Chen, Xuewen, Pearce, Jane B, Sumner, Susan, Krupenko, Sergey A, Hursting, Stephen D

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Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors von Doerstling, Steven S, O'Flanagan, Ciara H, Hursting, Stephen D

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Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes von Kim, Minsoo, Gorelick, Alexander N., Vàzquez-García, Ignacio, Williams, Marc J., Salehi, Sohrab, Shi, Hongyu, Weiner, Adam C., Ceglia, Nick, Funnell, Tyler, Park, Tricia, Boscenco, Sonia, O’Flanagan, Ciara H., Jiang, Hui, Grewal, Diljot, Tang, Cerise, Rusk, Nicole, Gammage, Payam A., McPherson, Andrew, Aparicio, Sam, Shah, Sohrab P., Reznik, Ed

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The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link von Bowers, Laura W, Rossi, Emily L, O'Flanagan, Ciara H, deGraffenried, Linda A, Hursting, Stephen D

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PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer von Cox, Orla T, Edmunds, Shelley J, Simon-Keller, Katja, Li, Bo, Moran, Bruce, Buckley, Niamh E, Bustamante-Garrido, Milan, Healy, Nollaig, O'Flanagan, Ciara H, Gallagher, William M, Kennedy, Richard D, Bernards, René, Caldas, Carlos, Chin, Suet-Feung, Marx, Alexander, O'Connor, Rosemary

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Translating Mechanism-Based Strategies to Break the Obesity−Cancer Link: A Narrative Review von Smith, Laura A., O’Flanagan, Ciara H., Bowers, Laura W., Allott, Emma H., Hursting, Stephen D.

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Effects of folic acid withdrawal on transcriptomic profiles in murine triple-negative breast cancer cell lines von Kok, Dieuwertje E., O’Flanagan, Ciara H., Coleman, Michael F., Ashkavand, Zahra, Hursting, Stephen D., Krupenko, Sergey A.

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IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin von O'Flanagan, Ciara H, O'Shea, Sandra, Lyons, Amy, Fogarty, Fionola M, McCabe, Nuala, Kennedy, Richard D, O'Connor, Rosemary

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Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer von O’Flanagan, Ciara H., Rossi, Emily L., McDonell, Shannon B., Chen, Xuewen, Tsai, Yi-Hsuan, Parker, Joel S., Usary, Jerry, Perou, Charles M., Hursting, Stephen D.

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PINK1, cancer and neurodegeneration von O'Flanagan, Ciara H, Morais, Vanessa A, O'Neill, Cora

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Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors von Lashinger, Laura M, O'Flanagan, Ciara H, Dunlap, Sarah M, Rasmussen, Audrey J, Sweeney, Shannon, Guo, Jessie Yangxiang, Lodi, Alessia, Tiziani, Stefano, White, Eileen, Hursting, Stephen D

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Abstract 4265: Transient versus permanent autophagy inhibition in pancreatic ductal adenocarcinoma von Pearce, Jane B., O'Flanagan, Ciara H., Hursting, Stephen D.

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Clonal fitness inferred from time-series modelling of single-cell cancer genomes von Salehi, Sohrab, Kabeer, Farhia, Ceglia, Nicholas, Andronescu, Mirela, Williams, Marc J., Campbell, Kieran R., Masud, Tehmina, Wang, Beixi, Biele, Justina, Brimhall, Jazmine, Gee, David, Lee, Hakwoo, Ting, Jerome, Zhang, Allen W., Tran, Hoa, O’Flanagan, Ciara, Dorri, Fatemeh, Rusk, Nicole, de Algara, Teresa Ruiz, Lee, So Ra, Cheng, Brian Yu Chieh, Eirew, Peter, Kono, Takako, Pham, Jenifer, Grewal, Diljot, Lai, Daniel, Moore, Richard, Mungall, Andrew J., Marra, Marco A., McPherson, Andrew, Bouchard-Côté, Alexandre, Aparicio, Samuel, Shah, Sohrab P.

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Abstract 1336: Autophagy inhibition reverses EMT and reduces 3D growth of pancreatic adenocarcinoma cells in vitro and in vivo von Pearce, Jane B., O'Flanagan, Ciara H., Hursting, Stephen D.

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Abstract 446: Differential effects of folate depletion on metabolic reprogramming and oxidative stress in nonmetastatic and metastatic claudin-low breast cancer cells von Chen, Xuewen, O'Flanagan, Ciara H., Hursting, Stephen D.

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