Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy von Hookham, Michelle B., O'Donovan, Helen C., Church, Rachel H., Mercier‐Zuber, Annie, Luzi, Lucilla, Curran, Simon P., Carew, Rosemarie M., Droguett, Alejandra, Mezzano, Sergio, Schubert, Markus, White, Morris F., Crean, John K., Brazil, Derek P.

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Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells von O'Donovan, Helen C, Hickey, Fionnuala, Brazil, Derek P, Kavanagh, David H, Oliver, Noelynn, Martin, Finian, Godson, Catherine, Crean, John

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Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR von O'Donovan, Helen C., Kiely, Patrick A., O'Connor, Rosemary

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Methylomic trajectories across human fetal brain development von Spiers, Helen, Hannon, Eilis, Schalkwyk, Leonard C, Smith, Rebecca, Wong, Chloe C Y, O'Donovan, Michael C, Bray, Nicholas J, Mill, Jonathan

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Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci von Hannon, Eilis, Spiers, Helen, Viana, Joana, Pidsley, Ruth, Burrage, Joe, Murphy, Therese M, Troakes, Claire, Turecki, Gustavo, O'Donovan, Michael C, Schalkwyk, Leonard C, Bray, Nicholas J, Mill, Jonathan

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Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's esophagus: a multi-center case-control study von Ross-Innes, Caryn S, Debiram-Beecham, Irene, O'Donovan, Maria, Walker, Elaine, Varghese, Sibu, Lao-Sirieix, Pierre, Lovat, Laurence, Griffin, Michael, Ragunath, Krish, Haidry, Rehan, Sami, Sarmed S, Kaye, Philip, Novelli, Marco, Disep, Babett, Ostler, Richard, Aigret, Benoit, North, Bernard V, Bhandari, Pradeep, Haycock, Adam, Morris, Danielle, Attwood, Stephen, Dhar, Anjan, Rees, Colin, Rutter, Matthew D D, Sasieni, Peter D, Fitzgerald, Rebecca C

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Substitution mutational signatures in whole-genome-sequenced cancers in the UK population von Degasperi, Andrea, Zou, Xueqing, Amarante, Tauanne Dias, Martinez-Martinez, Andrea, Koh, Gene Ching Chiek, Dias, João M L, Heskin, Laura, Chmelova, Lucia, Rinaldi, Giuseppe, Wang, Valerie Ya Wen, Nanda, Arjun S, Bernstein, Aaron, Momen, Sophie E, Young, Jamie, Perez-Gil, Daniel, Memari, Yasin, Badja, Cherif, Shooter, Scott, Czarnecki, Jan, Brown, Matthew A, Davies, Helen R, Nik-Zainal, Serena

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Population-Based Study Reveals New Risk-Stratification Biomarker Panel for Barrett's Esophagus von Bird–Lieberman, Elizabeth L, Dunn, Jason M, Coleman, Helen G, Lao–Sirieix, Pierre, Oukrif, Dahmane, Moore, Christina E, Varghese, Sibu, Johnston, Brian T, Arthur, Kenneth, McManus, Damian T, Novelli, Marco R, O'Donovan, Maria, Cardwell, Christopher R, Lovat, Laurence B, Murray, Liam J, Fitzgerald, Rebecca C

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Acceptability and accuracy of a non-endoscopic screening test for Barrett’s oesophagus in primary care: cohort study von Kadri, Sudarshan R, Lao-Sirieix, Pierre, O’Donovan, Maria, Debiram, Irene, Das, Madhumita, Blazeby, Jane M, Emery, Jon, Boussioutas, Alex, Morris, Helen, Walter, Fiona M, Pharoah, Paul, Hardwick, Richard H, Fitzgerald, Rebecca C

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The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic von Frankell, Alexander M., Jammula, SriGanesh, Li, Xiaodun, Contino, Gianmarco, Killcoyne, Sarah, Abbas, Sujath, Perner, Juliane, Bower, Lawrence, Devonshire, Ginny, Ococks, Emma, Grehan, Nicola, Mok, James, O’Donovan, Maria, MacRae, Shona, Eldridge, Matthew D., Tavaré, Simon, Fitzgerald, Rebecca C.

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The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer von Trotman, Jamie, Armstrong, Ruth, Firth, Helen, Trayers, Claire, Watkins, James, Allinson, Kieren, Jacques, Thomas S., Nicholson, James C., Burke, G. A. Amos, Behjati, Sam, Murray, Matthew J., Hook, Catherine E., Tarpey, Patrick

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Widespread genomic influences on phenotype in Dravet syndrome, a ‘monogenic’ condition von Martins Custodio, Helena, Clayton, Lisa M, Bellampalli, Ravishankara, Pagni, Susanna, Silvennoinen, Katri, Caswell, Richard, Brunklaus, Andreas, Guerrini, Renzo, Koeleman, Bobby P C, Lemke, Johannes R, Møller, Rikke S, Scheffer, Ingrid E, Weckhuysen, Sarah, Zara, Federico, Zuberi, Sameer, Kuchenbaecker, Karoline, Balestrini, Simona, Mills, James D, Sisodiya, Sanjay M

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Genome-wide association study identifies eight loci associated with blood pressure von Newton-Cheh, Christopher, Johnson, Toby, Gateva, Vesela, Tobin, Martin D, Coin, Lachlan, Zhao, Jing Hua, Zhang, Feng, Farrall, Martin, Tanaka, Toshiko, Wallace, Chris, Chambers, John C, Khaw, Kay-Tee, van der Harst, Pim, Polidoro, Silvia, Elliott, Katherine S, Teumer, Alexander, Luan, Jian'an, Kuusisto, Johanna, Hadley, David, McArdle, Wendy L, Dominiczak, Anna, Samani, Nilesh J, Webster, John, Beckmann, Jacques S, Bergmann, Sven, Lim, Noha, Song, Kijoung, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Yuan, Xin, Orho-Melander, Marju, Allione, Alessandra, Di Gregorio, Alessandra, Guarrera, Simonetta, Panico, Salvatore, Barroso, Inês, Sandhu, Manjinder S, Luben, Robert N, Crawford, Gabriel J, Jousilahti, Pekka, Perola, Markus, Bonnycastle, Lori L, Collins, Francis S, Jackson, Anne U, Stringham, Heather M, Valle, Timo T, Bergman, Richard N, Gieger, Christian, Illig, Thomas, Kathiresan, Sekar, O'Donnell, Christopher J, Subirana, Isaac, Freimer, Nelson B, O'Reilly, Paul F, Peltonen, Leena, Pouta, Anneli, de Jong, Paul E, Snieder, Harold, van Gilst, Wiek H, Clarke, Robert, Hamsten, Anders, Peden, John F, Seedorf, Udo, Lakatta, Edward G, Sanna, Serena, Scuteri, Angelo, Dörr, Marcus, Ernst, Florian, Felix, Stephan B, Homuth, Georg, Gut, Ivo G, Lathrop, G Mark, Zelenika, Diana, Deloukas, Panos, Soranzo, Nicole, Williams, Frances M, Salomaa, Veikko, Laakso, Markku, Elosua, Roberto, Forouhi, Nita G, Völzke, Henry, Uiterwaal, Cuno S, van der Schouw, Yvonne T, Matullo, Giuseppe, Navis, Gerjan, Berglund, Göran, Kooner, Jaspal S, Bandinelli, Stefania, Watkins, Hugh, Tuomilehto, Jaakko, Altshuler, David, Laan, Maris, Meneton, Pierre, Jarvelin, Marjo-Riitta, Mooser, Vincent, Melander, Olle, Elliott, Paul, Caulfield, Mark, Munroe, Patricia B

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Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs von Prieto, Maria Luz, O'Sullivan, Laurie, Tan, Shiau Pin, McLoughlin, Peter, Hughes, Helen, O'Donovan, Orla, Rea, Mary C, Kent, Robert M, Cassidy, Joseph P, Gardiner, Gillian E, Lawlor, Peadar G

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls von Clayton, David G, Cardon, Lon R, Duncanson, Audrey, Ouwehand, Willem H, Todd, John A, Donnelly, Peter, Easton, Doug, Evans, David, Morris, Andrew P, Spencer, Chris C. A, Boorman, James P, Cant, Barbara, Everson, Ursula, Hussey, Judith M, Knight, Alexandra S, Nutland, Sarah, Stevens, Helen E, Watkins, Nicholas A, Jones, Richard W, Ring, Susan M, Breen, Gerome, Caesar, Sian, Green, Elaine K, Grozeva, Detelina, Jones, Ian R, Kirov, George, Moskvina, Valentina, Nikolov, Ivan, Collier, David A, Farmer, Anne, Williamson, Richard, Young, Allan H, Ball, Stephen G, Balmforth, Anthony J, Bishop, D. Timothy, Iles, Mark M, Dixon, Richard J, Stevens, Suzanne, Thompson, John R, Bredin, Francesca, Tremelling, Mark, Drummond, Hazel, Nimmo, Elaine R, Fisher, Sheila A, Forbes, Alastair, Lewis, Cathryn M, Prescott, Natalie J, Barbour, Jamie, Mohiuddin, M. Khalid, Mansfield, John C, Cummings, Fraser R, Connell, John, Dobson, Richard, Gungadoo, Johannie, Newhouse, Stephen J, Barton, Anne, Bruce, Ian N, John, Sally L, Potter, Catherine, Silman, Alan J, Symmons, Deborah P. M, Dunger, David B, Widmer, Barry, Frayling, Timothy M, Lango, Hana, Perry, John R. B, Groves, Christopher J, Rayner, Nigel W, Timpson, Nicholas J, Zeggini, Eleftheria, Newport, Melanie, Vannberg, Fredrik, Farrar, Claire, Wordsworth, Paul, Brown, Matthew A, Franklyn, Jayne A, Heward, Joanne M, Simmonds, Matthew J, Seal, Sheila, Stratton, Michael R, Ban, Maria, Conway, David, Chaney, Amy, Ghori, Mohammed J. R, Gwilliam, Rhian, Hunt, Sarah E, McGinnis, Ralph, Potter, Simon, Whittaker, Pamela, Widden, Claire, Withers, David, Hallgrimsdottir, Ingileif B, Vukcevic, Damjan, Bentley, David, Caulfield, Mark, Compston, Alistair, Farrall, Martin, Hall, Alistair S, Hattersley, Andrew T, Mathew, Christopher G

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Common variants near MC4R are associated with fat mass, weight and risk of obesity von Loos, Ruth J F, Lindgren, Cecilia M, Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, Inouye, Michael, Freathy, Rachel M, Attwood, Antony P, Beckmann, Jacques S, Berndt, Sonja I, Bergmann, Sven, Bennett, Amanda J, Bingham, Sheila A, Bochud, Murielle, Brown, Morris, Cauchi, Stéphane, Connell, John M, Cooper, Cyrus, Smith, George Davey, Day, Ian, Dina, Christian, De, Subhajyoti, Dermitzakis, Emmanouil T, Doney, Alex S F, Elliott, Katherine S, Elliott, Paul, Evans, David M, Sadaf Farooqi, I, Froguel, Philippe, Ghori, Jilur, Groves, Christopher J, Gwilliam, Rhian, Hadley, David, Hall, Alistair S, Hattersley, Andrew T, Hebebrand, Johannes, Heid, Iris M, Herrera, Blanca, Hinney, Anke, Hunt, Sarah E, Jarvelin, Marjo-Riitta, Johnson, Toby, Jolley, Jennifer D M, Karpe, Fredrik, Keniry, Andrew, Khaw, Kay-Tee, Luben, Robert N, Mangino, Massimo, Marchini, Jonathan, McArdle, Wendy L, McGinnis, Ralph, Meyre, David, Munroe, Patricia B, Morris, Andrew D, Ness, Andrew R, Neville, Matthew J, Nica, Alexandra C, Ong, Ken K, O'Rahilly, Stephen, Owen, Katharine R, Palmer, Colin N A, Papadakis, Konstantinos, Potter, Simon, Pouta, Anneli, Qi, Lu, Randall, Joshua C, Rayner, Nigel W, Ring, Susan M, Sandhu, Manjinder S, Scherag, André, Sims, Matthew A, Song, Kijoung, Soranzo, Nicole, Speliotes, Elizabeth K, Syddall, Holly E, Teichmann, Sarah A, Timpson, Nicholas J, Tobias, Jonathan H, Uda, Manuela, Ganz Vogel, Carla I, Wallace, Chris, Waterworth, Dawn M, Weedon, Michael N, Willer, Cristen J, Wraight, Vicki L, Yuan, Xin, Zeggini, Eleftheria, Hirschhorn, Joel N, Strachan, David P, Ouwehand, Willem H, Caulfield, Mark J, Samani, Nilesh J, Vollenweider, Peter, Waeber, Gerard, Mooser, Vincent, Deloukas, Panos, McCarthy, Mark I, Wareham, Nicholas J, Barroso, Inês

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An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy von Pagnamenta, Alistair T, Kaiyrzhanov, Rauan, Zou, Yaqun, Da'as, Sahar I, Maroofian, Reza, Donkervoort, Sandra, Dominik, Natalia, Lauffer, Marlen, Ferla, Matteo P, Orioli, Andrea, Giess, Adam, Tucci, Arianna, Beetz, Christian, Sedghi, Maryam, Ansari, Behnaz, Barresi, Rita, Basiri, Keivan, Cortese, Andrea, Elgar, Greg, Fernandez-Garcia, Miguel A, Yip, Janice, Foley, A Reghan, Gutowski, Nicholas, Jungbluth, Heinz, Lassche, Saskia, Lavin, Tim, Marcelis, Carlo, Marks, Peter, Marini-Bettolo, Chiara, Medne, Livija, Moslemi, Ali-Reza, Sarkozy, Anna, Reilly, Mary M, Muntoni, Francesco, Millan, Francisca, Muraresku, Colleen C, Need, Anna C, Nemeth, Andrea H, Neuhaus, Sarah B, Norwood, Fiona, O'Donnell, Marie, O'Driscoll, Mary, Rankin, Julia, Yum, Sabrina W, Zolkipli-Cunningham, Zarazuela, Brusius, Isabell, Wunderlich, Gilbert, Karakaya, Mert, Wirth, Brunhilde, Fakhro, Khalid A, Tajsharghi, Homa, Bönnemann, Carsten G, Taylor, Jenny C, Houlden, Henry

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Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration von Vetro, Annalisa, Pelorosso, Cristiana, Balestrini, Simona, Masi, Alessio, Hambleton, Sophie, Argilli, Emanuela, Giubbolini, Simone, Barrick, Rebekah, Bergant, Gaber, Writzl, Karin, Bijlsma, Emilia K., Cacheiro, Pilar, Mei, Davide, Devlin, Anita, Machol, Keren, Mannaioni, Guido, Sakamoto, Masamune, Menezes, Manoj P., Courtin, Thomas, Sherr, Elliott, Parra, Riccardo, Richardson, Ruth, Roscioli, Tony, Scala, Marcello, von Stülpnagel, Celina, Smedley, Damian, Pochiero, Francesca, Ramesh, Venkateswaran, Capra, Valeria, Mancardi, Margherita, Keren, Boris, Mignot, Cyiril, Lulli, Matteo, Parks, Kendall, Griffin, Helen, Nigro, Vincenzo, Hirata, Yuko, Koichihara, Reiko, Peterlin, Borut, Maki, Ryuto, Nitta, Yohei, Ambrose, John C., Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boustred, Christopher R., Brittain, Helen, Brown, Matthew A., Caulfield, Mark J., Chan, Georgia C., Giess, Adam, Griffin, John N., Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Lakey, Anna, Lopez, Javier F., Maleady-Crowe, Fiona, Minneci, Federico, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Rahim, Tahrima, Rendon, Augusto, Sawant, Kushmita, Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Zarowiecki, Magdalena, Torella, Annalaura, Tohyama, Jun, Hamada, Keisuke, Ogata, Kazuhiro, Sugie, Atsushi, van der Smagt, Jasper J., van Gassen, Koen, Valence, Stephanie, Vittery, Emma, Malone, Stephen, Kato, Mitsuhiro, Ratto, Gian Michele, Guerrini, Renzo

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Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis von Paterson, Anna L, O'Donovan, Maria, Provenzano, Elena, Murray, Liam J, Coleman, Helen G, Johnson, Brian T, McManus, Damian T, Novelli, Marco, Lovat, Laurence B, Fitzgerald, Rebecca C

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Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease von Claus, Laura R., Chen, Chuan, Stallworth, Jennifer, Turner, Joshua L., Slaats, Gisela G., Mabillard, Holly, Senum, Sarah R., Srikanth, Sujata, Flanagan-Steet, Heather, Louie, Raymond J., Silver, Josh, Lerner-Ellis, Jordan, Morel, Chantal, Mighton, Chloe, Sleutels, Frank, van Slegtenhorst, Marjon, van Ham, Tjakko, Brooks, Alice S., Dorresteijn, Eiske M., Barakat, Tahsin Stefan, Dahan, Karin, Demoulin, Nathalie, Goffin, Eric Jean, Olinger, Eric, Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boardman-Pretty, Freya, Boustred, Christopher R., Brittain, Helen, Caulfield, Mark J., Chan, Georgia C., Elgar, Greg, Fowler, Tom, Giess, Adam, Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, McEntagart, Meriel, Minneci, Federico, Moutsianas, Loukas, Mueller, Michael, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Pereira, Mariana Buongermino, Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Sosinsky, Alona, Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Thompson, Simon R., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Larsen, Martin, Hertz, Jens Michael, Lilien, Marc R., Obeidová, Lena, Stone, Hillarey K., Kerecuk, Larissa, Gurgu, Mihai, Yousef Yengej, Fjodor A., Ammerlaan, Carola M.E., Rookmaaker, Maarten B., Hanna, Christian, Rogers, R. Curtis, Duran, Karen, Peters, Edith, Sayer, John A., van Haaften, Gijs, Harris, Peter C., Ling, Kun, Mason, Jennifer M., van Eerde, Albertien M., Steet, Richard

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