Addressing the Reciprocal Crosstalk between the AR and the PI3K/AKT/mTOR Signaling Pathways for Prostate Cancer Treatment von Raith, Fabio, O'Donovan, Daniel H, Lemos, Clara, Politz, Oliver, Haendler, Bernard

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Rapid Identification of Novel Allosteric PRC2 Inhibitors von Read, Jon A, Tart, Jonathan, Rawlins, Philip B, Gregson, Clare, Jones, Karen, Gao, Ning, Zhu, Xiahui, Tomlinson, Ron, Code, Erin, Cheung, Tony, Chen, Huawei, Kawatkar, Sameer P, Bloecher, Andy, Bagal, Sharan, O’Donovan, Daniel H, Robinson, James

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Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion von Kidd, Sarah L, Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias, Aimon, Anthony, Bradley, Anthony, Fairhead, Michael, Brear, Paul, Díaz-Sáez, Laura, McAuley, Katherine, Sore, Hannah F, Madin, Andrew, O'Donovan, Daniel H, Huber, Kilian V. M, Hyvönen, Marko, von Delft, Frank, Dowson, Christopher G, Spring, David R

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Dual Nucleophilic/Electrophilic Capture of In Situ Generated Iminium Ethers: Towards the Synthesis of Functionalized Amide Building Blocks von Peng, Bo, O'Donovan, Daniel H., Jurberg, Igor D., Maulide, Nuno

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A concise synthesis of asymmetrical N,N′-disubstituted guanidines von O’Donovan, Daniel H., Rozas, Isabel

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Drug discovery for epigenetics targets von Holdgate, Geoffrey A, Bardelle, Catherine, Lanne, Alice, Read, Jon, O'Donovan, Daniel H, Smith, James M, Selmi, Nidhal, Sheppard, Robert

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Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches von Carlino, Luca, Astles, Peter C., Ackroyd, Bryony, Ahmed, Afshan, Chan, Christina, Collie, Gavin W., Dale, Ian L., O’Donovan, Daniel H., Fawcett, Caroline, di Fruscia, Paolo, Gohlke, Andrea, Guo, Xiaoxiao, Hao-Ru Hsu, Jessie, Kaplan, Bethany, Milbradt, Alexander G., Northall, Sarah, Petrović, Dušan, Rivers, Emma L., Underwood, Elizabeth, Webb, Alice

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Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist von Scott, James S, Moss, Thomas A, Balazs, Amber, Barlaam, Bernard, Breed, Jason, Carbajo, Rodrigo J, Chiarparin, Elisabetta, Davey, Paul R. J, Delpuech, Oona, Fawell, Stephen, Fisher, David I, Gagrica, Sladjana, Gangl, Eric T, Grebe, Tyler, Greenwood, Ryan D, Hande, Sudhir, Hatoum-Mokdad, Holia, Herlihy, Kara, Hughes, Samantha, Hunt, Thomas A, Huynh, Hoan, Janbon, Sophie L. M, Johnson, Tony, Kavanagh, Stefan, Klinowska, Teresa, Lawson, Mandy, Lister, Andrew S, Marden, Stacey, McGinnity, Dermot F, Morrow, Christopher J, Nissink, J. Willem M, O’Donovan, Daniel H, Peng, Bo, Polanski, Radoslaw, Stead, Darren S, Stokes, Stephen, Thakur, Kumar, Throner, Scott R, Tucker, Michael J, Varnes, Jeffrey, Wang, Haixia, Wilson, David M, Wu, Dedong, Wu, Ye, Yang, Bin, Yang, Wenzhan

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Pyridin-2-yl Guanidine Derivatives: Conformational Control Induced by Intramolecular Hydrogen-Bonding Interactions von Kelly, Brendan, O'Donovan, Daniel H, O'Brien, John, McCabe, Thomas, Blanco, Fernando, Rozas, Isabel

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Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity von O'Donovan, Daniel H., Muguruza, Carolina, Callado, Luis F., Rozas, Isabel

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New methods for the preparation of aryl 2-iminoimidazolidines von O’Donovan, Daniel H., Rozas, Isabel

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Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives von Nagle, Padraic S, Quinn, Susan J, Kelly, John M, O'Donovan, Daniel H, Khan, Amir R, Rodriguez, Fernando, Nguyen, Binh, Wilson, W David, Rozas, Isabel

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A structural study of N,N′-bis-aryl-N′′-acylguanidines von O'Donovan, Daniel H., Kelly, Brendan, Diez-Cecilia, Elena, Kitson, Martin, Rozas, Isabel

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Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs) von Cooper, Bethany M, Iegre, Jessica, O' Donovan, Daniel H, Ölwegård Halvarsson, Maria, Spring, David R

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex von Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O’ Donovan, Daniel H., Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew

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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists von Scott, James S., Stead, Darren, Barlaam, Bernard, Breed, Jason, Carbajo, Rodrigo J., Chiarparin, Elisabetta, Cureton, Natalie, Davey, Paul R. J., Fisher, David I., Gangl, Eric T., Grebe, Tyler, Greenwood, Ryan D., Hande, Sudhir, Hatoum-Mokdad, Holia, Hughes, Samantha J., Hunt, Thomas A., Johnson, Tony, Kavanagh, Stefan L., Klinowska, Teresa C. M., Larner, Carrie J. B., Lawson, Mandy, Lister, Andrew S., Longmire, David, Marden, Stacey, McGuire, Thomas M., McMillan, Caroline, McMurray, Lindsay, Morrow, Christopher J., Nissink, J. Willem M., Moss, Thomas A., O’Donovan, Daniel H., Polanski, Radoslaw, Stokes, Stephen, Thakur, Kumar, Trueman, Dawn, Truman, Caroline, Tucker, Michael J., Wang, Haixia, Whalley, Nicky, Wu, Dedong, Wu, Ye, Yang, Bin, Yang, Wenzhan

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C−H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity von O' Donovan, Daniel H., Aillard, Paul, Berger, Martin, de la Torre, Aurélien, Petkova, Desislava, Knittl‐Frank, Christian, Geerdink, Danny, Kaiser, Marcel, Maulide, Nuno

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The reductive cleavage of picolinic amides von O’ Donovan, Daniel H., De Fusco, Claudia, Spring, David R.

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Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice von O' Donovan, Daniel H., Baker, David, Ciotta, Giovanni, Degorce, Sébastien L., Demanze, Sylvain, Dockerill, Milly, Escudero-Ibarz, Leire, Ireland, Lucy, Mao, Yumeng, Packer, Martin J., Robinson, James, Scarfe, Graeme, Tang, Haoran, Valge-Archer, Viia

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Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction von Iegre, Jessica, Brear, Paul, Baker, David J, Tan, Yaw Sing, Atkinson, Eleanor L, Sore, Hannah F, O' Donovan, Daniel H, Verma, Chandra S, Hyvönen, Marko, Spring, David R

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