Discovery of Clinical Candidate 2‑((2S,6S)‑2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid D... von Ye, Xiang-Yang, Chen, Stephanie Y, Wu, Shung, Yoon, David S, Wang, Haixia, Hong, Zhenqiu, O’Connor, Stephen P, Li, Jun, Li, James J, Kennedy, Lawrence J, Walker, Steven J, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Ramamurthy, Vidyhashankar, Morin, Paul E, Zebo, Rachel, Taylor, Joseph R, Morgan, Nathan N, Ponticiello, Randolph P, Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W, Sleczka, Bogdan G, He, Bin, Kirby, Mark, Leahy, David K, Li, Jianqing, Hanson, Ronald L, Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D, Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C, Gordon, David A, Robl, Jeffrey A

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Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors von Meng, Wei, Brigance, Robert P, Chao, Hannguang J, Fura, Aberra, Harrity, Thomas, Marcinkeviciene, Jovita, O’Connor, Stephen P, Tamura, James K, Xie, Dianlin, Zhang, Yaqun, Klei, Herbert E, Kish, Kevin, Weigelt, Carolyn A, Turdi, Huji, Wang, Aiying, Zahler, Robert, Kirby, Mark S, Hamann, Lawrence G

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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1) von Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Wang, Haixia, Li, James J, Hong, Zhenqiu, O’Connor, Stephen P, Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S, Nayeem, Akbar, Camac, Daniel M, Ramamurthy, Vidhyashankar, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A, Robl, Jeffrey A

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Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1) von Li, Jun, Kennedy, Lawrence J, Wang, Haixia, Li, James J, Walker, Steven J, Hong, Zhenqiu, O’Connor, Stephen P, Nayeem, Akbar, Camac, Daniel M, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Gordon, David A, Robl, Jeffrey A

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Enantioselective Cyclopropanation of Allylic Alcohols. The Effect of Zinc Iodide von Denmark, Scott E, O'Connor, Stephen P

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Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors von O’Connor, Stephen P., Wang, Ying, Simpkins, Ligaya M., Brigance, Robert P., Meng, Wei, Wang, Aiying, Kirby, Mark S., Weigelt, Carolyn A., Hamann, Lawrence G.

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Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors von Shi, Yan, Zhang, Jing, Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Sitkoff, Doree, Pudzianowski, Andrew T., Chong, Saeho, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.

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Catalytic, Enantioselective Cyclopropanation of Allylic Alcohols. Substrate Generality von Denmark, Scott E, O'Connor, Stephen P

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Solution and Solid-State Studies of a Chiral Zinc-Sulfonamide Complex Relevant to Enantioselective Cyclopropanations von Denmark, Scott E., O'Connor, Stephen P., Wilson, Scott R.

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Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors von Shi, Yan, Sitkoff, Doree, Zhang, Jing, Han, Wei, Hu, Zilun, Stein, Philip D., Wang, Ying, Kennedy, Lawrence J., O’Connor, Stephen P., Ahmad, Saleem, Liu, Eddie C.-K., Seiler, Steve M., Lam, Patrick Y.S., Robl, Jeffrey A., Macor, John E., Atwal, Karnail S., Zahler, Robert

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Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors von Shi, Yan, O’Connor, Stephen P., Sitkoff, Doree, Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Li, Chi, Ruan, Zheming, Michael Lawrence, R., Klei, Herbert E., Kish, Kevin, Liu, Eddie C.-K., Seiler, Steve M., Schweizer, Liang, Steinbacher, Thomas E., Schumacher, William A., Robl, Jeffrey A., Macor, John E., Atwal, Karnail S., Stein, Philip D.

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Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577 von Shi, Yan, Li, Chi, O’Connor, Stephen P., Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Sitkoff, Doree, Pudzianowski, Andrew T., Huang, Christine, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.

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Synthesis and evaluation of acylguanidine FXa inhibitors von O’Connor, Stephen P., Atwal, Karnail, Li, Chi, Liu, Eddie C.-K., Seiler, Steven M., Shi, Mengxiao, Shi, Yan, Stein, Philip D., Wang, Ying

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Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors von Shi, Yan, Zhang, Jing, Stein, Philip D., Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Atwal, Karnail S., Bisacchi, Gregory S., Sitkoff, Doree, Pudzianowski, Andrew T., Liu, Eddie C., Hartl, Karen S., Seiler, Steven M., Youssef, Sonia, Steinbacher, Thomas E., Schumacher, William A., Rendina, Alan R., Bozarth, Jeffrey M., Peterson, Tara L., Zhang, Ge, Zahler, Robert

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Synthesis of spiroketal-modified avermectin analogs: 23-nor-23-oxa- and 23-nor-23-thia-avermectins von Meinke, Peter T., O'Connor, Stephen P., Fisher, Michael H., Mrozik, Helmut

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Synthesis of ring-contracted, 25-nor-6,5-spiroketal-modified avermectin derivatives von Meinke, Peter T., O'Connor, Stephen P., Mrozik, Helmut, Fisher, Michael H.

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Catalytic enantioselective cyclopropanation with bis(halomethyl)zinc reagents. II. The effect of promoter structure on selectivity von Denmark, Scott E., Christenson, Beritte L., O'Connor, Stephen P.

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Catalytic enantioselective cyclopropanation with bis(halomethyl)zinc reagents. I. Optimization of reaction protocol von Denmark, Scott E., Christenson, Beritte L., Coe, Diane M., O'Connor, Stephen P.

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Electrode insertion tools, lead assemblies, kits and methods for placement of cardiac device electrodes von O'CONNOR STEPHEN A. P

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New vistas in organoelement chemistry von Denmark, S. E., Christenson, B. L., O'Connor, S. P., Murase, N.

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