Targeting the DNA Damage Response in Cancer von O’Connor, Mark J.

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Targeting the replication stress response in cancer von Forment, Josep V., O’Connor, Mark J.

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PARP Inhibitors: Extending Benefit Beyond BRCA -Mutant Cancers von Pilié, Patrick G, Gay, Carl M, Byers, Lauren A, O'Connor, Mark J, Yap, Timothy A

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A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds von Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos

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Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically von Riches, Lucy C., Trinidad, Antonio G., Hughes, Gareth, Jones, Gemma N., Hughes, Adina M., Thomason, Andrew G., Gavine, Paul, Cui, Andy, Ling, Stephanie, Stott, Jonathan, Clark, Roger, Peel, Samantha, Gill, Pendeep, Goodwin, Louise M., Smith, Aaron, Pike, Kurt G., Barlaam, Bernard, Pass, Martin, O'Connor, Mark J., Smith, Graeme, Cadogan, Elaine B.

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors von Jaspers, Janneke E, Kersbergen, Ariena, Boon, Ute, Sol, Wendy, van Deemter, Liesbeth, Zander, Serge A, Drost, Rinske, Wientjens, Ellen, Ji, Jiuping, Aly, Amal, Doroshow, James H, Cranston, Aaron, Martin, Niall M B, Lau, Alan, O'Connor, Mark J, Ganesan, Shridar, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

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ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation von Vendetti, Frank P, Karukonda, Pooja, Clump, David A, Teo, Troy, Lalonde, Ronald, Nugent, Katriana, Ballew, Matthew, Kiesel, Brian F, Beumer, Jan H, Sarkar, Saumendra N, Conrads, Thomas P, O'Connor, Mark J, Ferris, Robert L, Tran, Phuoc T, Delgoffe, Greg M, Bakkenist, Christopher J

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The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo von Vendetti, Frank P, Lau, Alan, Schamus, Sandra, Conrads, Thomas P, O'Connor, Mark J, Bakkenist, Christopher J

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Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper von Illuzzi, Giuditta, Staniszewska, Anna D, Gill, Sonja J, Pike, Andy, McWilliams, Lisa, Critchlow, Susan E, Cronin, Anna, Fawell, Stephen, Hawthorne, Glen, Jamal, Kunzah, Johannes, Jeffrey, Leonard, Emilyanne, Macdonald, Ruth, Maglennon, Gareth, Nikkilä, Jenni, O'Connor, Mark J, Smith, Aaron, Southgate, Harriet, Wilson, Joanne, Yates, James, Cosulich, Sabina, Leo, Elisabetta

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Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress von Young, Lucy A, O'Connor, Lenka Oplustil, de Renty, Christelle, Veldman-Jones, Margaret H, Dorval, Thierry, Wilson, Zena, Jones, David R, Lawson, Deborah, Odedra, Rajesh, Maya-Mendoza, Apolinar, Reimer, Corinne, Bartek, Jiri, Lau, Alan, O'Connor, Mark J

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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for P... von Johannes, Jeffrey W., Balazs, Amber, Barratt, Derek, Bista, Michal, Chuba, Matthew D., Cosulich, Sabina, Critchlow, Susan E., Degorce, Sebastien L., Di Fruscia, Paolo, Edmondson, Scott D., Embrey, Kevin, Fawell, Stephen, Ghosh, Avipsa, Gill, Sonja J., Gunnarsson, Anders, Hande, Sudhir M., Heightman, Tom D., Hemsley, Paul, Illuzzi, Giuditta, Lane, Jordan, Larner, Carrie, Leo, Elisabetta, Liu, Lina, Madin, Andrew, Martin, Scott, McWilliams, Lisa, O'Connor, Mark J., Orme, Jonathan P., Pachl, Fiona, Packer, Martin J., Pei, Xiaohui, Pike, Andrew, Schimpl, Marianne, She, Hongyao, Staniszewska, Anna D., Talbot, Verity, Underwood, Elizabeth, Varnes, Jeffrey G., Xue, Lin, Yao, Tieguang, Zhang, Ke, Zhang, Andrew X., Zheng, Xiaolan

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Klinefelter Syndrome and Diabetes von O’Connor, Mark J., Snyder, Emma A., Hayes, Frances J.

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Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification von Pellegrino, Benedetta, Herencia-Ropero, Andrea, Llop-Guevara, Alba, Pedretti, Flaminia, Moles-Fernández, Alejandro, Viaplana, Cristina, Villacampa, Guillermo, Guzmán, Marta, Rodríguez, Olga, Grueso, Judit, Jiménez, Jose, Arenas, Enrique J, Degasperi, Andrea, Dias, João M L, Forment, Josep V, O'Connor, Mark J, Déas, Olivier, Cairo, Stefano, Zhou, Yinghui, Musolino, Antonino, Caldas, Carlos, Nik-Zainal, Serena, Clarke, Robert B, Nuciforo, Paolo, Díez, Orland, Serres-Créixams, Xavier, Peg, Vicente, Espinosa-Bravo, Martín, Macarulla, Teresa, Oaknin, Ana, Mateo, Joaquin, Arribas, Joaquín, Dienstmann, Rodrigo, Bellet, Meritxell, Oliveira, Mafalda, Saura, Cristina, Gutiérrez-Enríquez, Sara, Balmaña, Judith, Serra, Violeta

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs von Rottenberg, Sven, Jaspers, Janneke E, Kersbergen, Ariena, van der Burg, Eline, Nygren, Anders O.H, Zander, Serge A.L, Derksen, Patrick W.B, de Bruin, Michiel, Zevenhoven, John, Lau, Alan, Boulter, Robert, Cranston, Aaron, O'Connor, Mark J, Martin, Niall M.B, Borst, Piet, Jonkers, Jos

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Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition von MCCABE, Nuala, TURNER, Nicholas C, SMITH, Graeme C. M, ASHWORTH, Alan, LORD, Christopher J, KLUZEK, Katarzyna, BIALKOWSKA, Aneta, SWIFT, Sally, GIAVARA, Sabrina, O'CONNOR, Mark J, TUFT, Andrew N, ZDZIENICKA, Malgorzata Z

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Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment von Naipal, Kishan A T, Verkaik, Nicole S, Ameziane, Najim, van Deurzen, Carolien H M, Ter Brugge, Petra, Meijers, Matty, Sieuwerts, Anieta M, Martens, John W, O'Connor, Mark J, Vrieling, Harry, Hoeijmakers, Jan H J, Jonkers, Jos, Kanaar, Roland, de Winter, Johan P, Vreeswijk, Maaike P, Jager, Agnes, van Gent, Dik C

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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition von Krawczyk, Przemek M, Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J, Buist, Marrije R, Soullié, Thomas, Rens, Joost, Verhagen, Hence J.M, O'Connor, Mark J, Franken, Nicolaas A.P, ten Hagen, Timo L.M, Kanaar, Roland, Aten, Jacob A

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion von Golding, Sarah E, Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F, Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A, O'Connor, Mark J, Povirk, Lawrence F, van Meter, Timothy, Valerie, Kristoffer

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ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation von Biddlestone-Thorpe, Laura, Sajjad, Muhammad, Rosenberg, Elizabeth, Beckta, Jason M, Valerie, Nicholas C K, Tokarz, Mary, Adams, Bret R, Wagner, Alison F, Khalil, Ashraf, Gilfor, Donna, Golding, Sarah E, Deb, Sumitra, Temesi, David G, Lau, Alan, O'Connor, Mark J, Choe, Kevin S, Parada, Luis F, Lim, Sang Kyun, Mukhopadhyay, Nitai D, Valerie, Kristoffer

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Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft von Senra, Joana M, Telfer, Brian A, Cherry, Kim E, McCrudden, Cian M, Hirst, David G, O'Connor, Mark J, Wedge, Stephen R, Stratford, Ian J

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