Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC von Heavey, Susan, O’Byrne, Kenneth J, Gately, Kathy

Volltext

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden von Hellmann, Matthew D, Ciuleanu, Tudor-Eliade, Pluzanski, Adam, Lee, Jong Seok, Otterson, Gregory A, Audigier-Valette, Clarisse, Minenza, Elisa, Linardou, Helena, Burgers, Sjaak, Salman, Pamela, Borghaei, Hossein, Ramalingam, Suresh S, Brahmer, Julie, Reck, Martin, O’Byrne, Kenneth J, Geese, William J, Green, George, Chang, Han, Szustakowski, Joseph, Bhagavatheeswaran, Prabhu, Healey, Diane, Fu, Yali, Nathan, Faith, Paz-Ares, Luis

Volltext

Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature von Barr, Martin P, Gray, Steven G, Hoffmann, Andreas C, Hilger, Ralf A, Thomale, Juergen, O'Flaherty, John D, Fennell, Dean A, Richard, Derek, O'Leary, John J, O'Byrne, Kenneth J

Volltext

The Role of Inflammation in the Pathogenesis of Non-small Cell Lung Cancer von O'Callaghan, Dermot S., O'Donnell, Dearbhaile, O'Connell, Finbarr, O'Byrne, Kenneth J.

Volltext

Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations von YANG, James Chih-Hsin, HIRSH, Vera, PALMER, Michael, SEQUIST, Lecia V, SCHULER, Martin, YAMAMOTO, Nobuyuki, O'BYRNE, Kenneth J, MOK, Tony S. K, ZAZULINA, Victoria, SHAHIDI, Mehdi, LUNGERSHAUSEN, Juliane, MASSEY, Dan

Volltext

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage von Bolderson, Emma, Burgess, Joshua T., Li, Jun, Gandhi, Neha S., Boucher, Didier, Croft, Laura V., Beard, Samuel, Plowman, Jennifer J., Suraweera, Amila, Adams, Mark N., Naqi, Ali, Zhang, Shu-Dong, Sinclair, David A., O’Byrne, Kenneth J., Richard, Derek J.

Volltext

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair von Sobanski, Thais, Suraweera, Amila, Burgess, Joshua T., Richard, Iain, Cheong, Chee Man, Dave, Keyur, Rose, Maddison, Adams, Mark N., O’Byrne, Kenneth J., Richard, Derek J., Bolderson, Emma

Volltext

EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX s... von Pirker, Robert, Prof, Pereira, Jose R, MD, von Pawel, Joachim, MD, Krzakowski, Maciej, Prof, Ramlau, Rodryg, MD, Park, Keunchil, Prof, de Marinis, Filippo, MD, Eberhardt, Wilfried EE, MD, Paz-Ares, Luis, MD, Störkel, Stephan, Prof, Schumacher, Karl-Maria, MD, von Heydebreck, Anja, PhD, Celik, Ilhan, Prof, O'Byrne, Kenneth J, Prof

Volltext

Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells von Shah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J., Adams, Mark N.

Volltext

Effects of HER Family-targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer von Collins, Denis M, Madden, Stephen F, Gaynor, Nicola, AlSultan, Dalal, Le Gal, Marion, Eustace, Alex J, Gately, Kathy A, Hughes, Clare, Davies, Anthony M, Mahgoub, Thamir, Ballot, Jo, Toomey, Sinead, O'Connor, Darran P, Gallagher, William M, Holmes, Frankie A, Espina, Virginia, Liotta, Lance, Hennessy, Bryan T, O'Byrne, Kenneth J, Hasmann, Max, Bossenmaier, Birgit, O'Donovan, Norma, Crown, John

Volltext

Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study von O'Byrne, Kenneth J, Prof, Gatzemeier, Ulrich, MD, Bondarenko, Igor, MD, Barrios, Carlos, MD, Eschbach, Corinna, MD, Martens, Uwe M, MD, Hotko, Yevhen, MD, Kortsik, Cornelius, MD, Paz-Ares, Luis, MD, Pereira, Jose R, MD, von Pawel, Joachim, MD, Ramlau, Rodryg, MD, Roh, Jae-Kyung, Prof, Yu, Chih-Teng, MD, Stroh, Christopher, PhD, Celik, Ilhan, Prof, Schueler, Armin, MS, Pirker, Robert, Prof

Volltext

Systemic and Intracranial Outcomes With First-Line Nivolumab Plus Ipilimumab in Patients With Metastatic NSCLC and Baseline Brain Metastases From CheckMate 227 Part 1 von Reck, Martin, Ciuleanu, Tudor-Eliade, Lee, Jong-Seok, Schenker, Michael, Zurawski, Bogdan, Kim, Sang-We, Mahave, Mauricio, Alexandru, Aurelia, Peters, Solange, Pluzanski, Adam, Caro, Reyes Bernabe, Linardou, Helena, Burgers, Jacobus A., Nishio, Makoto, Martinez-Marti, Alex, Azuma, Koichi, Axelrod, Rita, Paz-Ares, Luis G., Ramalingam, Suresh S., Borghaei, Hossein, O’Byrne, Kenneth J., Li, Li, Bushong, Judith, Gupta, Ravi G., Grootendorst, Diederik J., Eccles, Laura J., Brahmer, Julie R.

Volltext

hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage von Boucher, Didier, Kariawasam, Ruvini, Burgess, Joshua, Gimenez, Adrian, Ocampo, Tristan E., Ferguson, Blake, Naqi, Ali, Walker, Graeme J., Bolderson, Emma, Gamsjaeger, Roland, O’Byrne, Kenneth J., Cubeddu, Liza, Khanna, Kum Kum, Richard, Derek J.

Volltext

Meta-analysis of individual patient data from randomized trials of chemotherapy plus cetuximab as first-line treatment for advanced non-small cell lung cancer von Pujol, Jean-Louis, Pirker, Robert, Lynch, Thomas J, Butts, Charles A, Rosell, Rafael, Shepherd, Frances A, Vansteenkiste, Johan, O’Byrne, Kenneth J, de Blas, Barbara, Heighway, Jim, von Heydebreck, Anja, Thatcher, Nick

Volltext

Sotorasib (960 mg or 240 mg) once daily in patients with previously treated KRAS G12C-mutated advanced NSCLC von Hochmair, Maximilian J., Vermaelen, Karim, Mountzios, Giannis, Carcereny, Enric, Dooms, Christophe, Lee, Se-Hoon, Morocz, Eva, Kato, Terufumi, Ciuleanu, Tudor-Eliade, Dy, Grace K., Parente, Barbara, O’Byrne, Kenneth J., Chu, Quincy S., Castro Junior, Gilberto De, Girard, Nicolas, Snyder, Wendy, Tran, Qui, Kormany, William, Houk, Brett, Mehta, Bhakti, Curioni-Fontecedro, Alessandra

Volltext

An Exploration of Small Molecules That Bind Human Single-Stranded DNA Binding Protein 1 von Schuurs, Zachariah P, Martyn, Alexander P, Soltau, Carl P, Beard, Sam, Shah, Esha T, Adams, Mark N, Croft, Laura V, O’Byrne, Kenneth J, Richard, Derek J, Gandhi, Neha S

Volltext

Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture von Ryan, Sarah-Louise, Baird, Anne-Marie, Vaz, Gisela, Urquhart, Aaron J, Senge, Mathias, Richard, Derek J, O'Byrne, Kenneth J, Davies, Anthony M

Volltext

The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer von Burgess, Joshua T., Rose, Maddison, Boucher, Didier, Plowman, Jennifer, Molloy, Christopher, Fisher, Mark, O'Leary, Connor, Richard, Derek J., O'Byrne, Kenneth J., Bolderson, Emma

Volltext

Macrophage and Mast-Cell Invasion of Tumor Cell Islets Confers a Marked Survival Advantage in Non–Small-Cell Lung Cancer von WELSH, Tomas J, GREEN, Ruth H, RICHARDSON, Donna, WALLER, David A, O'BYRNE, Kenneth J, BRADDING, Peter

Volltext

Human single-stranded DNA binding proteins are essential for maintaining genomic stability von Ashton, Nicholas W, Bolderson, Emma, Cubeddu, Liza, O'Byrne, Kenneth J, Richard, Derek J

Volltext