Characterization of Novel Selective H1-Antihistamines for Clinical Evaluation in the Treatment of Insomnia von Moree, Wilna J, Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S, Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham

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A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects von Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham, Bozigian, Haig P.

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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease von Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H

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Novel benzothiophene H1-antihistamines for the treatment of insomnia von MOREE, Wilna J, JOVIC, Florence, HERNANDEZ, Lisa M, O'BRIEN, Zhihong, JIANYUN WEN, HUA WANG, HOARE, Samuel R. J, PETROSKI, Robert E, SACAAN, Aida, MADAN, Ajay, CROWE, Paul D, BEATON, Graham, COON, Timothy, JINGHUA YU, LI, Bin-Feng, TUCCI, Fabio C, MARINKOVIC, Dragan, GROSS, Raymond S, MALANY, Siobhan, BRADBURY, Margaret J

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Abstract C101: Preclinical and clinical pharmacokinetics (PK) of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP),... von Hall, Michael, O'Brien, Zhihong, Zabludoff, Sonya

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Validation and application of a liquid chromatography–tandem mass spectrometric method for the simultaneous determination of testosterone and dihydrotestosterone in rat prostatic t... von O’Brien, Zhihong, Post, Noah, Brown, Michael, Madan, Ajay, Coon, Timothy, Luo, Rosa, Kohout, Trudy A.

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First-in-human dose-escalation study of NBF-006, a novel investigational siRNA targeting GSTP, in patients with non-small cell lung, pancreatic, or colorectal cancer von Tolcher, Anthony W., Spira, Alexander I., Nemunaitis, John J., Vandross, Andrae Lavon, Mamdani, Hirva, O'Brien, Zhihong, Huynh, Annie, Albaugh, Zachary, Gullbo, Joachim, Zabludoff, Sonya

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Characterization of Novel Selective H 1 -Antihistamines for Clinical Evaluation in the Treatment of Insomnia von Moree, Wilna J., Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S., Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J., Hernandez, Lisa M., O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J., Petroski, Robert E., Sacaan, Aida, Madan, Ajay, Crowe, Paul D., Beaton, Graham

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Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer von Cina, Cima, Harborth, Jens, O'Brien, Zhihong, Beltran-Raygoza, Nish, Jin, Jung-kang, Xu, Jessica, Lee, Sang Jun, Tsang, Kwok, Yao, Jiping, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer von O'Brien, Zhihong, Wang, Li, Majeti, Bharat, Clamme, Jeanpierre, Baclig, Robiel, Chu, James, Fong, Steven, Harborth, Jens, Ibarra, Jose, Yin, Haiqing, Yu, Jing, Zhang, Clayton, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.

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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy von Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John

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A pharmacokinetic evaluation of five H 1 antagonists after an oral and intravenous microdose to human subjects von Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham, Bozigian, Haig P.

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Novel benzothiophene H 1-antihistamines for the treatment of insomnia von Moree, Wilna J., Jovic, Florence, Coon, Timothy, Yu, Jinghua, Li, Bin-Feng, Tucci, Fabio C., Marinkovic, Dragan, Gross, Raymond S., Malany, Siobhan, Bradbury, Margaret J., Hernandez, Lisa M., O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R.J., Petroski, Robert E., Sacaan, Aida, Madan, Ajay, Crowe, Paul D., Beaton, Graham

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships von Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John

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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von Lanier, Marion C, Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E, Zhang, Xiaohu, Williams, John P, Gross, Raymond S, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I, Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H

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Abstract 4060: Discovery and preclinical development of KRAS-targeting siRNA therapeutic modality for the treatment of pancreatic cancer von OBrien, Zhihong (Julie), Wang, Li, Cina, Cima, Majeti, Bharat, Chu, James, Wang, Xiaoen, Baclig, Robiel, Lin, James, Ibarra, Jose, Chatterjee, Dhrubamitra, Jin, Jung-Kang, Clamme, Jean-Pierre, Daniels, Jennifer, Wang, Hai, Harborth, Jens, Ying, Wenbin

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Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2- c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists von Chen, Mi, Guo, Zhiqiang, Lanier, Marion C., Zhao, Liren, Betz, Stephen F., Huang, Charles Q., Loweth, Colin J., Ashweek, Neil J., Liu, Xin-Jun, Struthers, R. Scott, Bradbury, Margaret J., Behan, James W., Wen, Jenny, O’Brien, Zhihong, Saunders, John, Zhu, Yun-Fei

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Novel benzothiophene H sub(1)-antihistamines for the treatment of insomnia von Moree, Wilna J, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Li, Bin-Feng, Tucci, Fabio C, Marinkovic, Dragan, Gross, Raymond S, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O'Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel RJ, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham

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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2AReceptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von LANIER, Marion C, MOORJANI, Manisha, MARKISON, Stacy, JOSWIG, Tanya, KARGO, William, PIERCEY, Jaime, SANTOS, Mark, MALANY, Siobhan, ZHAO, Marilyn, PETROSKI, Robert, CRESPO, Maria I, DIAZ, Jose-Luis, ZHIYONG LUO, SAUNDERS, John, WEN, Jenny, O'BRIEN, Zhihong, JALALI, Kayvon, MADAN, Ajay, SLEE, Deborah H, YONGSHENG CHEN, LIN, Emily, TELLEW, John E, XIAOHU ZHANG, WILLIAMS, John P, GROSS, Raymond S, LECHNER, Sandra M

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