TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK von Schweighoffer, Edina, Nys, Josquin, Vanes, Lesley, Smithers, Nicholas, Tybulewicz, Victor L J

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The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway von Schweighoffer, Edina, Vanes, Lesley, Nys, Josquin, Cantrell, Doreen, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L.J.

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A helminth-derived suppressor of ST2 blocks allergic responses von Vacca, Francesco, Chauche, Caroline, Jamwal, Abhishek, Hinchy, Elizabeth C., Heieis, Graham, Webster, Holly, Ogunkanbr, Adefunke, Sekne, Zala, Gregory, William F., Wear, Martin, Perona-Wright, Georgia, Higgins, Matthew K., Nys, Josquin A., Cohen, E. Suzanne, McSorley, Henry J.

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No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells von Nys, Josquin, Smulski, Cristian R, Tardivel, Aubry, Willen, Laure, Kowalczyk, Christine, Donzé, Olivier, Huard, Bertrand, Hess, Henry, Schneider, Pascal

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A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells von Haselmayer, Philipp, Vigolo, Michele, Nys, Josquin, Schneider, Pascal, Hess, Henry

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Su1794 TOLERABILITY, SAFETY, AND CLINICAL PHARMACOLOGY OF AZD7798, A DEPLETING ANTIBODY TARGETING CCR9 von Harper, Andrew R., Bouma, Gerben, Lundahl, Anna, Larsson, Julia, Bock, David, Eck, Steven, Duncan, Marnie, Nys, Josquin, Mo, John, Gehrmann, Ulf, Arkhammar, Per, Kiraga, Joanna, Popinska, Agnieszka, Soto, Pablo Forte, Belvisi, Maria G., Fowler, Andrew, Marks, Daniel J.

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Su1770 AZD7798: A NEW CCR9 DEPLETING ANTIBODY TO TREAT CROHN'S DISEASE von Nys, Josquin, Thom, George, Cariuk, Peter, Riley, Aidan, Kelly, Aoife, Swieboda, Dawid P., Huntington, Catherine, Rees, D.G., Irving, Lorraine M., Schofield, Darren, Daramola, Lekan, Stebbings, Richard, Marks, Daniel J.

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Sa2018 FIRST-TIME-IN-HUMAN VISUALISATION OF CCR9 EXPRESSION IN THE GUT BY POSITRON EMISSION TOMOGRAPHY von MacKay, James, Jucaite, Aurelija, Cselényi, Zsolt, Johnström, Peter, Dahl, Kenneth, Schou, Magnus, Stenkrona, Per, Sousa, Vasco C., Högnäsbacka, Antonia, Gonzalez, Miguel A. Cortes, Giffen, Paul, Bouma, Gerben, Nys, Josquin, Brülls, Mikael, Duncan, Marnie, Larsson, Julia, Lundahl, Anna, Les, Karolina A., Bergare, Jonas, Elmore, Charles S., Kiraga, Joanna, Blé, François-Xavier, Fowler, Andrew, Belvisi, Maria G., Marks, Daniel J.

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Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival von Ackermann, Jochen A, Nys, Josquin, Schweighoffer, Edina, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L J

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[11C]Vercirnon - a candidate PET radioligand for the CCR9 chemokine receptor von Högnäsbacka, Antonia, Cortes Gonzalez, Miguel Angel, Cselenyi, Zsolt, Jucaite, Aurelija, Dahl, Kenneth, Johnstrom, Peter, Sousa, Vasco, Bergare, Jonas, Nys, Josquin, Gardiner, Philip, Brülls, Mikael, Gehrmann, Ulf, Ble, Francois-Xavier, Les, Karolina, Elmore, Charles, Mackay, Jamie, Halldin, Christer, Marks, Daniel, Schou, Magnus

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Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover von Corkill, Dominic J., Hunt, Alan N., Hinrichs, Mary Jane, White, Nicholas, Rebelatto, Marlon, Roskos, Lorin, Nys, Josquin, Scott, Alison, Robinson, Matthew J., Ryan, Patricia, Postle, Anthony D., Sleeman, Matthew A.

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Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties von Schuepbach-Mallepell, Sonia, Das, Dolon, Willen, Laure, Vigolo, Michele, Tardivel, Aubry, Lebon, Luc, Kowalczyk-Quintas, Christine, Nys, Josquin, Smulski, Cristian, Zheng, Timothy S., Maskos, Klaus, Lammens, Alfred, Jiang, Xuliang, Hess, Henry, Tan, Seng-Lai, Schneider, Pascal

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Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung von Campbell, Jamie, Nys, Josquin, Eghobamien, Laura, Cohen, E Suzanne, Robinson, Matthew J, Sleeman, Matthew A

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No Evidence That Soluble TACI Induces Signalling via Membrane-Expressed BAFF and APRIL in Myeloid Cells. e61350 von Nys, Josquin, Smulski, Cristian R, Tardivel, Aubry, Willen, Laure, Kowalczyk, Christine, Donze, Olivier, Huard, Bertrand, Hess, Henry, Schneider, Pascal

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Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease von Dennison, Thomas W, Edgar, Rachel D, Payne, Felicity, Nayak, Komal M, Ross, Alexander DB, Cenier, Aurelie, Glemas, Claire, Giachero, Federica, Foster, April R, Harris, Rebecca, Kraiczy, Judith, Salvestrini, Camilla, Stavrou, Georgia, Torrente, Franco, Brook, Kimberley, Trayers, Claire, Elmentaite, Rasa, Youssef, Gehad, Tél, Bálint, Winton, Douglas James, Skoufou-Papoutsaki, Nefeli, Adler, Sam, Bufler, Philip, Azabdaftari, Aline, Jenke, Andreas, G, Natasha, Thomas, Natasha, Miele, Erasmo, Al-Mohammad, Abdulrahman, Guarda, Greta, Kugathasan, Subra, Venkateswaran, Suresh, Clatworthy, Menna R, Castro-Dopico, Tomas, Suchanek, Ondrej, Strisciuglio, Caterina, Gasparetto, Marco, Lee, Seokjun, Xu, Xingze, Bello, Erica, Han, Namshik, Zerbino, Daniel R, Teichmann, Sarah A, Nys, Josquin, Heuschkel, Robert, Perrone, Francesca, Zilbauer, Matthias

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Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease von Dennison, Thomas W, Edgar, Rachel D, Payne, Felicity, Nayak, Komal M, Ross, Alexander D. B, Cenier, Aurelie, Glemas, Claire, Giachero, Federica, Foster, April R, Harris, Rebecca, Kraiczy, Judith, Salvestrini, Camilla, Stavrou, Georgia, Torrente, Franco, Brook, Kimberley, Trayers, Claire, Elmentaite, Rasa, Youssef, Gehad, Tél, Bálint, Winton, Douglas James, Skoufou-Papoutsaki, Nefeli, Adler, Sam, Bufler, Philip, Azabdaftari, Aline, Jenke, Andreas, G, Natasha, Thomas, Natasha, Miele, Erasmo, Al-Mohammad, Abdulrahman, Guarda, Greta, Kugathasan, Subra, Venkateswaran, Suresh, Clatworthy, Menna R, Castro-Dopico, Tomas, Suchanek, Ondrej, Strisciuglio, Caterina, Gasparetto, Marco, Lee, Seokjun, Xu, Xingze, Bello, Erica, Han, Namshik, Zerbino, Daniel R, Teichmann, Sarah A, Nys, Josquin, Heuschkel, Robert, Perrone, Francesca, Zilbauer, Matthias

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Therapeutic binding molecules von Thom, Albert, Huntington, Catherine, Nys, Josquin, Cariuk, Peter, Riley, Aidan, Rees, David, Schofield, Darren, Irving, Lorraine, Robinson, Matthew

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THERAPEUTIC BINDING MOLECULES von REES, David Gareth, NYS, Josquin Arnaud, HUNTINGTON, Catherine Eugenie Chaillan, ROBINSON, Matthew, THOM, Albert George, CARIUK, Peter, RILEY, Aidan, SCHOFIELD, Darren Jonathan, IRVING, Lorraine

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THERAPEUTIC BINDING MOLECULES von REES, David Gareth, NYS, Josquin Arnaud, HUNTINGTON, Catherine Eugenie Chaillan, ROBINSON, Matthew, THOM, Albert George, CARIUK, Peter, RILEY, Aidan, SCHOFIELD, Darren Jonathan, IRVING, Lorraine

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THERAPEUTIC BINDING MOLECULE THAT BINDS TO CCR9 von REES, David Gareth, NYS, Josquin Arnaud, HUNTINGTON, Catherine Eugenie Chaillan, ROBINSON, Matthew, THOM, Albert George, CARIUK, Peter, RILEY, Aidan, SCHOFIELD, Darren Jonathan, IRVING, Lorraine

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