Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis von Klint, Susanne, Feldwisch, Joachim, Gudmundsdotter, Lindvi, Dillner Bergstedt, Karin, Gunneriusson, Elin, Höidén Guthenberg, Ingmarie, Wennborg, Anders, Nyborg, Andrew C, Kamboj, Amol P, Peloso, Paul M, Bejker, David, Frejd, Fredrik Y

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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties von Nyborg, Andrew C, Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C, Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O'Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N, Wilson, David M, Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y, Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A, Osbourn, Jane, Coats, Steven, Baca, Manuel

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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk von Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A

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Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells von Nyborg, Andrew C, Zacco, Anna, Ettinger, Rachel, Jack Borrok, M, Zhu, Jie, Martin, Tom, Woods, Rob, Kiefer, Christine, Bowen, Michael A, Suzanne Cohen, E., Herbst, Ronald, Wu, Herren, Coats, Steven

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains von Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.

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C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation von Wang, Jun, Beher, Dirk, Nyborg, Andrew C., Shearman, Mark S., Golde, Todd E., Goate, Alison

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Pegloticase co-administered with high MW polyethylene glycol effectively reduces PEG-immunogenicity and restores prolonged circulation in mouse von Li, Zhongbo, Shen, Limei, Ma, Alice, Talkington, Anne, Li, Zibo, Nyborg, Andrew C., Bowers, M. Scott, LaMoreaux, Brian, Livingston, Eric W., Frank, Jonathan E., Yuan, Hong, Lai, Samuel K.

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High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies von Talkington, Anne M., McSweeney, Morgan D., Zhang, Tao, Li, Zibo, Nyborg, Andrew C., LaMoreaux, Brian, Livingston, Eric W., Frank, Jonathan E., Yuan, Hong, Lai, Samuel K.

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Flavodoxin Hydroquinone Reduces Azotobacter vinelandii Fe Protein to the All-Ferrous Redox State with a S = 0 Spin State von Lowery, Thomas J., Wilson, Phillip E., Zhang, Bo, Bunker, Jared, Harrison, Roger G., Nyborg, Andrew C., Thiriot, David, Watt, Gerald D.

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Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase von Nyborg, Andrew C, Ladd, Thomas B, Jansen, Karen, Kukar, Thomas, Golde, Todd E

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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates von Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E

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A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells von Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Zhang, Zhifen, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Melnyk, Roman A., Spiller, Benjamin W., Lacy, D. Borden

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A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the S... von Nyborg, Andrew C, Jansen, Karen, Ladd, Thomas B, Fauq, Abdul, Golde, Todd E

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Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface von Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Ohi, Melanie D., Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Spiller, Benjamin W., Lacy, D. Borden

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Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy von Herl, Lauren, Lleo, Alberto, Thomas, Anne V., Nyborg, Andrew C., Jansen, Karen, Golde, Todd E., Hyman, Bradley T., Berezovska, Oksana

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Signal Peptide Peptidase:  Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs von Sato, Toru, Nyborg, Andrew C, Iwata, Nobuhisa, Diehl, Thekla S, Saido, Takaomi C, Golde, Todd E, Wolfe, Michael S

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Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor von Nyborg, Andrew C., Kornilova, Anna Y., Jansen, Karen, Ladd, Thomas B., Wolfe, Michael S., Golde, Todd E.

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Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells von Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E

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Targeting the junction of CɛmX and ɛ-migis for the specific depletion of mIgE-expressing B cells von Chowdhury, Partha S., Chen, Yan, Yang, Chunning, Cook, Kimberly E., Nyborg, Andrew C., Ettinger, Rachel, Herbst, Ronald, Kiener, Peter A., Wu, Herren

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Overexpression of nicastrin increases Abeta production von Murphy, M Paul, Das, Pritam, Nyborg, Andrew C, Rochette, Marjorie J, Dodson, Mark W, Loosbrock, Nicole M, Souder, Terrance M, McLendon, Chris, Merit, Sami L, Piper, Siân C, Jansen, Karen R, Golde, Todd E

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