136. Participation or Engagement? Audit of an Education and Exercise Programme for Inflammatory Joint Disease von Dean, Allison, Nutland, Helen, Smith, Hilary, Nisar, Mohamed, Laxminarayan, Ram, Arthanari, Subha

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Population structure, differential bias and genomic control in a large-scale, case-control association study von Clayton, David G, Walker, Neil M, Smyth, Deborah J, Pask, Rebecca, Cooper, Jason D, Maier, Lisa M, Smink, Luc J, Lam, Alex C, Ovington, Nigel R, Stevens, Helen E, Nutland, Sarah, Howson, Joanna M M, Faham, Malek, Moorhead, Martin, Jones, Hywel B, Falkowski, Matthew, Hardenbol, Paul, Willis, Thomas D, Todd, John A

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Haplotype tagging for the identification of common disease genes von Johnson, Gillian C.L., Esposito, Laura, Barratt, Bryan J., Smith, Annabel N., Heward, Joanne, Di Genova, Gianfranco, Ueda, Hironori, Cordell, Heather J., Eaves, Iain A., Dudbridge, Frank, Twells, Rebecca C.J., Payne, Felicity, Hughes, Wil, Nutland, Sarah, Stevens, Helen, Carr, Phillipa, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Gough, Stephen C.L., Clayton, David G., Todd, John A.

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Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus von SMYTH, Deborah, COOPER, Jason D, BARRATT, Bryan J, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A, DUNGER, David B, WIDMER, Barry, STRACHAN, David P, RING, Susan M, WALKER, Neil, CLAYTON, David G, COLLINS, Joanne E, TWELLS, Rebecca C. J, GOUGH, Stephen C. L, TODD, John A, HEWARD, Joanne M, FRANKLYN, Jayne A, HOWSON, Joanna M. M, VELLA, Adrian, NUTLAND, Sarah, RANCE, Helen E, MAIER, Lisa

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Genome-wide association study identifies eight loci associated with blood pressure von Newton-Cheh, Christopher, Johnson, Toby, Gateva, Vesela, Tobin, Martin D, Coin, Lachlan, Zhao, Jing Hua, Zhang, Feng, Farrall, Martin, Tanaka, Toshiko, Wallace, Chris, Chambers, John C, Khaw, Kay-Tee, van der Harst, Pim, Polidoro, Silvia, Elliott, Katherine S, Teumer, Alexander, Luan, Jian'an, Kuusisto, Johanna, Hadley, David, McArdle, Wendy L, Dominiczak, Anna, Samani, Nilesh J, Webster, John, Beckmann, Jacques S, Bergmann, Sven, Lim, Noha, Song, Kijoung, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Yuan, Xin, Orho-Melander, Marju, Allione, Alessandra, Di Gregorio, Alessandra, Guarrera, Simonetta, Panico, Salvatore, Barroso, Inês, Sandhu, Manjinder S, Luben, Robert N, Crawford, Gabriel J, Jousilahti, Pekka, Perola, Markus, Bonnycastle, Lori L, Collins, Francis S, Jackson, Anne U, Stringham, Heather M, Valle, Timo T, Bergman, Richard N, Gieger, Christian, Illig, Thomas, Kathiresan, Sekar, O'Donnell, Christopher J, Subirana, Isaac, Freimer, Nelson B, O'Reilly, Paul F, Peltonen, Leena, Pouta, Anneli, de Jong, Paul E, Snieder, Harold, van Gilst, Wiek H, Clarke, Robert, Hamsten, Anders, Peden, John F, Seedorf, Udo, Lakatta, Edward G, Sanna, Serena, Scuteri, Angelo, Dörr, Marcus, Ernst, Florian, Felix, Stephan B, Homuth, Georg, Gut, Ivo G, Lathrop, G Mark, Zelenika, Diana, Deloukas, Panos, Soranzo, Nicole, Williams, Frances M, Salomaa, Veikko, Laakso, Markku, Elosua, Roberto, Forouhi, Nita G, Völzke, Henry, Uiterwaal, Cuno S, van der Schouw, Yvonne T, Matullo, Giuseppe, Navis, Gerjan, Berglund, Göran, Kooner, Jaspal S, Bandinelli, Stefania, Watkins, Hugh, Tuomilehto, Jaakko, Altshuler, David, Laan, Maris, Meneton, Pierre, Jarvelin, Marjo-Riitta, Mooser, Vincent, Melander, Olle, Elliott, Paul, Caulfield, Mark, Munroe, Patricia B

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Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene von Nejentsev, Sergey, Godfrey, Lisa, Snook, Hywel, Rance, Helen, Nutland, Sarah, Walker, Neil M., Lam, Alex C., Guja, Cristian, Ionescu-Tirgoviste, Constantin, Undlien, Dag E., Rønningen, Kjersti S., Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Newport, Melanie J., Clayton, David G., Todd, John A.

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls von Clayton, David G, Cardon, Lon R, Duncanson, Audrey, Ouwehand, Willem H, Todd, John A, Donnelly, Peter, Easton, Doug, Evans, David, Morris, Andrew P, Spencer, Chris C. A, Boorman, James P, Cant, Barbara, Everson, Ursula, Hussey, Judith M, Knight, Alexandra S, Nutland, Sarah, Stevens, Helen E, Watkins, Nicholas A, Jones, Richard W, Ring, Susan M, Breen, Gerome, Caesar, Sian, Green, Elaine K, Grozeva, Detelina, Jones, Ian R, Kirov, George, Moskvina, Valentina, Nikolov, Ivan, Collier, David A, Farmer, Anne, Williamson, Richard, Young, Allan H, Ball, Stephen G, Balmforth, Anthony J, Bishop, D. Timothy, Iles, Mark M, Dixon, Richard J, Stevens, Suzanne, Thompson, John R, Bredin, Francesca, Tremelling, Mark, Drummond, Hazel, Nimmo, Elaine R, Fisher, Sheila A, Forbes, Alastair, Lewis, Cathryn M, Prescott, Natalie J, Barbour, Jamie, Mohiuddin, M. Khalid, Mansfield, John C, Cummings, Fraser R, Connell, John, Dobson, Richard, Gungadoo, Johannie, Newhouse, Stephen J, Barton, Anne, Bruce, Ian N, John, Sally L, Potter, Catherine, Silman, Alan J, Symmons, Deborah P. M, Dunger, David B, Widmer, Barry, Frayling, Timothy M, Lango, Hana, Perry, John R. B, Groves, Christopher J, Rayner, Nigel W, Timpson, Nicholas J, Zeggini, Eleftheria, Newport, Melanie, Vannberg, Fredrik, Farrar, Claire, Wordsworth, Paul, Brown, Matthew A, Franklyn, Jayne A, Heward, Joanne M, Simmonds, Matthew J, Seal, Sheila, Stratton, Michael R, Ban, Maria, Conway, David, Chaney, Amy, Ghori, Mohammed J. R, Gwilliam, Rhian, Hunt, Sarah E, McGinnis, Ralph, Potter, Simon, Whittaker, Pamela, Widden, Claire, Withers, David, Hallgrimsdottir, Ingileif B, Vukcevic, Damjan, Bentley, David, Caulfield, Mark, Compston, Alistair, Farrall, Martin, Hall, Alistair S, Hattersley, Andrew T, Mathew, Christopher G

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Common variants near MC4R are associated with fat mass, weight and risk of obesity von Loos, Ruth J F, Lindgren, Cecilia M, Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, Inouye, Michael, Freathy, Rachel M, Attwood, Antony P, Beckmann, Jacques S, Berndt, Sonja I, Bergmann, Sven, Bennett, Amanda J, Bingham, Sheila A, Bochud, Murielle, Brown, Morris, Cauchi, Stéphane, Connell, John M, Cooper, Cyrus, Smith, George Davey, Day, Ian, Dina, Christian, De, Subhajyoti, Dermitzakis, Emmanouil T, Doney, Alex S F, Elliott, Katherine S, Elliott, Paul, Evans, David M, Sadaf Farooqi, I, Froguel, Philippe, Ghori, Jilur, Groves, Christopher J, Gwilliam, Rhian, Hadley, David, Hall, Alistair S, Hattersley, Andrew T, Hebebrand, Johannes, Heid, Iris M, Herrera, Blanca, Hinney, Anke, Hunt, Sarah E, Jarvelin, Marjo-Riitta, Johnson, Toby, Jolley, Jennifer D M, Karpe, Fredrik, Keniry, Andrew, Khaw, Kay-Tee, Luben, Robert N, Mangino, Massimo, Marchini, Jonathan, McArdle, Wendy L, McGinnis, Ralph, Meyre, David, Munroe, Patricia B, Morris, Andrew D, Ness, Andrew R, Neville, Matthew J, Nica, Alexandra C, Ong, Ken K, O'Rahilly, Stephen, Owen, Katharine R, Palmer, Colin N A, Papadakis, Konstantinos, Potter, Simon, Pouta, Anneli, Qi, Lu, Randall, Joshua C, Rayner, Nigel W, Ring, Susan M, Sandhu, Manjinder S, Scherag, André, Sims, Matthew A, Song, Kijoung, Soranzo, Nicole, Speliotes, Elizabeth K, Syddall, Holly E, Teichmann, Sarah A, Timpson, Nicholas J, Tobias, Jonathan H, Uda, Manuela, Ganz Vogel, Carla I, Wallace, Chris, Waterworth, Dawn M, Weedon, Michael N, Willer, Cristen J, Wraight, Vicki L, Yuan, Xin, Zeggini, Eleftheria, Hirschhorn, Joel N, Strachan, David P, Ouwehand, Willem H, Caulfield, Mark J, Samani, Nilesh J, Vollenweider, Peter, Waeber, Gerard, Mooser, Vincent, Deloukas, Panos, McCarthy, Mark I, Wareham, Nicholas J, Barroso, Inês

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes von Todd, John A, Walker, Neil M, Cooper, Jason D, Smyth, Deborah J, Downes, Kate, Plagnol, Vincent, Bailey, Rebecca, Nejentsev, Sergey, Field, Sarah F, Payne, Felicity, Lowe, Christopher E, Szeszko, Jeffrey S, Hafler, Jason P, Zeitels, Lauren, Yang, Jennie H M, Vella, Adrian, Nutland, Sarah, Stevens, Helen E, Schuilenburg, Helen, Coleman, Gillian, Maisuria, Meeta, Meadows, William, Smink, Luc J, Healy, Barry, Burren, Oliver S, Lam, Alex A C, Ovington, Nigel R, Allen, James, Adlem, Ellen, Leung, Hin-Tak, Wallace, Chris, Howson, Joanna M M, Guja, Cristian, Ionescu-Tîrgovişte, Constantin, Simmonds, Matthew J, Heward, Joanne M, Gough, Stephen C L, Dunger, David B, Wicker, Linda S, Clayton, David G

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Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles von Esposito, Laura, Hunter, Kara M D, Clark, Jan, Rainbow, Daniel B, Stevens, Helen, Denesha, Jennifer, Duley, Simon, Dawson, Sarah, Coleman, Gillian, Nutland, Sarah, Bell, Gwynneth L, Moran, Carla, Pekalski, Marcin, Todd, John A, Wicker, Linda S

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Genome-wide and fine-resolution association analysis of malaria in West Africa von Jallow, Muminatou, Teo, Yik Ying, Small, Kerrin S, Rockett, Kirk A, Deloukas, Panos, Clark, Taane G, Kivinen, Katja, Bojang, Kalifa A, Conway, David J, Pinder, Margaret, Sirugo, Giorgio, Sisay-Joof, Fatou, Usen, Stanley, Auburn, Sarah, Bumpstead, Suzannah J, Campino, Susana, Coffey, Alison, Dunham, Andrew, Fry, Andrew E, Green, Angela, Gwilliam, Rhian, Hunt, Sarah E, Inouye, Michael, Jeffreys, Anna E, Mendy, Alieu, Palotie, Aarno, Potter, Simon, Ragoussis, Jiannis, Rogers, Jane, Rowlands, Kate, Somaskantharajah, Elilan, Whittaker, Pamela, Widden, Claire, Donnelly, Peter, Howie, Bryan, Marchini, Jonathan, Morris, Andrew, SanJoaquin, Miguel, Achidi, Eric Akum, Agbenyega, Tsiri, Allen, Angela, Amodu, Olukemi, Corran, Patrick, Djimde, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara K, Drakeley, Chris, Dunstan, Sarah, Evans, Jennifer, Farrar, Jeremy, Fernando, Deepika, Hien, Tran Tinh, Horstmann, Rolf D, Ibrahim, Muntaser, Karunaweera, Nadira, Kokwaro, Gilbert, Koram, Kwadwo A, Lemnge, Martha, Makani, Julie, Marsh, Kevin, Michon, Pascal, Modiano, David, Molyneux, Malcolm E, Mueller, Ivo, Parker, Michael, Peshu, Norbert, Plowe, Christopher V, Puijalon, Odile, Reeder, John, Reyburn, Hugh, Riley, Eleanor M, Sakuntabhai, Anavaj, Singhasivanon, Pratap, Sirima, Sodiomon, Tall, Adama, Taylor, Terrie E, Thera, Mahamadou, Troye-Blomberg, Marita, Williams, Thomas N, Wilson, Michael, Kwiatkowski, Dominic P

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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease von Fisher, Sheila A, Tremelling, Mark, Anderson, Carl A, Gwilliam, Rhian, Bumpstead, Suzannah, Prescott, Natalie J, Nimmo, Elaine R, Massey, Dunecan, Berzuini, Carlo, Johnson, Christopher, Barrett, Jeffrey C, Cummings, Fraser R, Drummond, Hazel, Lees, Charlie W, Onnie, Clive M, Hanson, Catherine E, Blaszczyk, Katarzyna, Inouye, Mike, Ewels, Philip, Ravindrarajah, Radhi, Keniry, Andrew, Hunt, Sarah, Carter, Martyn, Watkins, Nick, Ouwehand, Willem, Lewis, Cathryn M, Cardon, Lon, Lobo, Alan, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Mansfield, John C, Deloukas, Panos, Mathew, Christopher G, Parkes, Miles, Satsangi, Jack

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Factors associated with reporting antibiotic use as STI prophylaxis among HIV PrEP users: findings from a cross-sectional online community survey, May-July 2019, UK von O'Halloran, Charlotte, Croxford, Sara, Mohammed, Hamish, Gill, Owen Noel, Hughes, Gwenda, Fifer, Helen, Allen, Hester, Owen, Greg, Nutland, Will, Delpech, Valerie, Saunders, John Michael

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Rheumatoid arthritis association at 6q23 von Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David, Worthington, Jane

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease von UEDA, Hironori, HOWSON, Joanna M. M, HERR, Mathias H, DAHLMAN, Ingrid, PAYNE, Felicity, SMYTH, Deborah, LOWE, Christopher, TWELLS, Rebecca C. J, HOWLETT, Sarah, HEALY, Barry, NUTLAND, Sarah, RANCE, Helen E, ESPOSITO, Laura, EVERETT, Vin, SMINK, Luc J, LAM, Alex C, CORDELL, Heather J, WALKER, Nell M, BORDIN, Cristina, HULME, John, MOTZO, Costantino, CUCCA, Francesco, HESS, J. Fred, HEWARD, Joanne, METZKER, Michael L, ROGERS, Jane, GREGORY, Simon, ALLAHABADIA, Amit, NITHLYANANTHAN, Ratnasingam, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, BINGLEY, Polly, GILLESPIE, Kathleen M, UNDLIEN, Dag E, SNOOK, Hywel, RENNINGEN, Kjersti S, GUJA, Cristlan, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A, MAXWELL, A. Peter, CARSON, Dennis J, PATTERSON, Chris C, FRANKLYN, Jayne A, CLAYTON, David G, PETERSON, Laurence B, CHAMBERLAIN, Giselle, WICKER, Linda S, TODD, John A, GOUGH, Stephen C. L, RAINBOW, Daniel B, HUNTER, Kara M. D, SMITH, Annabel N, DI GENOVA, Gianfranco

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Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing von SZESZKO, Jeffrey S, HOWSON, Joanna M. M, COOPER, Jason D, WALKER, Neil M, TWELLS, Rebecca C. J, STEVENS, Helen E, NUTLAND, Sarah L, TODD, John A

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Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene von Davison, Lucy J., Wallace, Chris, Cooper, Jason D., Cope, Nathan F., Wilson, Nicola K., Smyth, Deborah J., Howson, Joanna M.M., Saleh, Nada, Al-Jeffery, Abdullah, Angus, Karen L., Stevens, Helen E., Nutland, Sarah, Duley, Simon, Coulson, Richard M.R., Walker, Neil M., Burren, Oliver S., Rice, Catherine M., Cambien, Francois, Zeller, Tanja, Munzel, Thomas, Lackner, Karl, Blankenberg, Stefan, Fraser, Peter, Gottgens, Berthold, Todd, John A.

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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors von Pekalski, Marcin L, Ferreira, Ricardo C, Coulson, Richard M R, Cutler, Antony J, Guo, Hui, Smyth, Deborah J, Downes, Kate, Dendrou, Calliope A, Castro Dopico, Xaquin, Esposito, Laura, Coleman, Gillian, Stevens, Helen E, Nutland, Sarah, Walker, Neil M, Guy, Catherine, Dunger, David B, Wallace, Chris, Tree, Timothy I M, Todd, John A, Wicker, Linda S

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Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes von NEJENTSEV, Sergey, COOPER, Jason D, UNDLIEN, Dag E, RØNNINGEN, Kjersti S, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, GILLESPIE, Kathleen M, RING, Susan M, STRACHAN, David P, WIDMER, Barry, DUNGER, David, TODDL, John A, GODFREY, Lisa, HOWSON, Joanna M. M, RANCE, Helen, NUTLAND, Sarah, WALKER, Neil M, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A

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Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients von Downes, Kate, Marcovecchio, M. Loredana, Clarke, Pamela, Cooper, Jason D., Ferreira, Ricardo C., Howson, Joanna M. M., Jolley, Jennifer, Nutland, Sarah, Stevens, Helen E., Walker, Neil M., Wallace, Chris, Dunger, David B., Todd, John A.

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