A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers von Smith, Patrick F., Krishnarajah, Janakan, Nunn, Philip A., Hill, Ron J., Karr, Dane, Tam, D., Masjedizadeh, Mohammad, Funk, Jens O., Gourlay, Steve G.

Volltext

Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease von Langrish, Claire L., Bradshaw, J. Michael, Francesco, Michelle R., Owens, Timothy D., Xing, Yan, Shu, Jin, LaStant, Jacob, Bisconte, Angelina, Outerbridge, Catherine, White, Stephen D., Hill, Ronald J., Brameld, Ken A., Goldstein, David M., Nunn, Philip A.

Volltext

Prolonged and tunable residence time using reversible covalent kinase inhibitors von Bradshaw, J Michael, McFarland, Jesse M, Paavilainen, Ville O, Bisconte, Angelina, Tam, Danny, Phan, Vernon T, Romanov, Sergei, Finkle, David, Shu, Jin, Patel, Vaishali, Ton, Tony, Li, Xiaoyan, Loughhead, David G, Nunn, Philip A, Karr, Dane E, Gerritsen, Mary E, Funk, Jens Oliver, Owens, Timothy D, Verner, Erik, Brameld, Ken A, Hill, Ronald J, Goldstein, David M, Taunton, Jack

Volltext

Phase 1 clinical trial evaluating safety, exposure and pharmacodynamics of BTK inhibitor tolebrutinib (PRN2246, SAR442168) von Owens, Timothy D., Smith, Patrick F., Redfern, Andrew, Xing, Yan, Shu, Jin, Karr, Dane E., Hartmann, Sonja, Francesco, Michelle R., Langrish, Claire L., Nunn, Philip A., Gourlay, Steven G.

Volltext

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function von Schnegelsberg, Birthe, Sun, Tung-Tien, Cain, Gary, Bhattacharya, Anindya, Nunn, Philip A, Ford, Anthony P D W, Vizzard, Margaret A, Cockayne, Debra A

Volltext

Discovery of Reversible Covalent Bruton’s Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib) von Owens, Timothy D, Brameld, Ken A, Verner, Erik J, Ton, Tony, Li, Xiaoyan, Zhu, Jiang, Masjedizadeh, Mohammad R, Bradshaw, J. Michael, Hill, Ronald J, Tam, Danny, Bisconte, Angelina, Kim, Eun Ok, Francesco, Michelle, Xing, Yan, Shu, Jin, Karr, Dane, LaStant, Jacob, Finkle, David, Loewenstein, Natalie, Haberstock-Debic, Helena, Taylor, Michael J, Nunn, Philip, Langrish, Claire L, Goldstein, David M

Volltext

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP von Cockayne, Debra A., Dunn, Philip M., Zhong, Yu, Rong, Weifang, Hamilton, Sara G., Knight, Gillian E., Ruan, Huai‐Zhen, Ma, Bei, Yip, Ping, Nunn, Philip, McMahon, Stephen B., Burnstock, Geoffrey, Ford, Anthony P. D. W.

Volltext

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats von Kaan, Timothy K. Y., Yip, Ping K., Patel, Sital, Davies, Meirion, Marchand, Fabien, Cockayne, Debra A., Nunn, Philip A., Dickenson, Anthony H., Ford, Anthony P. D. W., Zhong, Yu, Malcangio, Marzia, McMahon, Stephen B.

Volltext

Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion, and absolute bioavailability in healthy participants von Ucpinar, Sibel, Smith, Patrick F., Long, Li, Li, Fujun, Yan, Hui, Wadhwa, Jyoti, Chu, Katherine A., Shu, Jin, Nunn, Philip, Li, Mengyao

Volltext

Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions von Chen, Gang, Panicker, Sandip, Lau, Kai-Yeung, Apparsundaram, Subramaniam, Patel, Vaishali A., Chen, Shiow-Ling, Soto, Rothschild, Jung, Jimmy K.C., Ravindran, Palanikumar, Okuhara, Dayne, Bohnert, Gary, Che, Qinglin, Rao, Patricia E., Allard, John D., Badi, Laura, Bitter, Hans-Marcus, Nunn, Philip A., Narula, Satwant K., DeMartino, Julie A.

Volltext

Purinoceptors as therapeutic targets for lower urinary tract dysfunction von Ford, Anthony P D W., Gever, Joel R., Nunn, Philip A., Zhong, Yu, Cefalu, Joseph S., Dillon, Michael P., Cockayne, Debra A.

Volltext

A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects von Ucpinar, Sibel, Darpo, Borje, Neale, Ann, Nunn, Philip, Shu, Jin, Chu, Katherine A., Kavanagh, Marianne, Xue, Hongqi, Phiasivongsa, Pasit, Thomas, Dolca, Smith, Patrick F.

Volltext

Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice von Smith, Christopher W., Campos, Joana, Brown, Helena C., Jooss, Natalie J., Ivanova, Vanesa-Sindi, Harbi, Maan, Garcia-Quintanilla, Lourdes, Jossi, Sian, Perez-Toledo, Marisol, Rookes, Kieran, Brill, Alexander, Theodore, Lindsay N., Owens, Tim, LaStant, Jacob, Foulke, Matthew C., Mukai, Shin, Francesco, Michelle, Storek, Michael, Hicks, Alexandra, Langrish, Claire, Nunn, Philip A., Cunningham, Adam F., Chauhan, Abhi, Thomas, Mark R., Watson, Steve P., Nicolson, Phillip L. R.

Volltext

The role of metabotropic glutamate receptor mGlu5 in control of micturition and bladder nociception von Hu, Youmin, Dong, Li, Sun, Biying, Guillon, Marlene A., Burbach, Leah R., Nunn, Philip A., Liu, Xingrong, Vilenski, Olga, Ford, Anthony P.D.W., Zhong, Yu, Rong, Weifang

Volltext

Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X3 and P2X2/3 Receptors in the Spinal Cord von Kaan, Timothy K. Y, Yip, Ping K, Grist, John, Cefalu, Joseph S, Nunn, Philip A, Ford, Anthony P. D. W, Zhong, Yu, McMahon, Stephen B

Volltext

An investigation of the effects of zaprinast, a PDE inhibitor, on the nitrergic control of the urethra in anaesthetized female rats von Wibberley, Alexandra, Nunn, Philip A, Naylor, Alasdair M, Ramage, Andrew G

Volltext

Efficacy of a Bruton's Tyrosine Kinase Inhibitor (PRN‐473) in the treatment of canine pemphigus foliaceus von Goodale, Elizabeth C., Varjonen, Katarina E., Outerbridge, Catherine A., Bizikova, Petra, Borjesson, Dori, Murrell, Dedee F., Bisconte, Angelina, Francesco, Michelle, Hill, Ronald J., Masjedizadeh, Mohammad, Nunn, Philip, Gourlay, Steven G., White, Stephen D.

Volltext

Open trial of Bruton’s tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus von Goodale, Elizabeth C., White, Stephen D., Bizikova, Petra, Borjesson, Dori, Murrell, Dedee F., Bisconte, Angelina, Francesco, Michelle, Hill, Ronald J., Masjedizadeh, Mohammad, Nunn, Philip, Gourlay, Steven G., Jordan, Tyler J.M., Emery, Carolyn B., Outerbridge, Catherine A.

Volltext

Tyk2 inhibitors and uses thereof von NUNN Philip

Volltext bestellen

PRN1008, a Reversible Covalent BTK Inhibitor in Clinical Development for Immune Thrombocytopenic Purpura von Langrish, Claire L, Bradshaw, J Michael, Owens, Timothy D, Campbell, Robert L, Francesco, Michelle R, Karr, Dane E, Murray, Steve K, Quesenberry, Robert C, Smith, Patrick F, Taylor, Michael D., Zhu, Jiang, Nunn, Philip A, Gourlay, Steven G

Volltext