A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma von Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cayanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.

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Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor von Rodrik-Outmezguine, Vanessa S., Okaniwa, Masanori, Yao, Zhan, Novotny, Chris J., McWhirter, Claire, Banaji, Arpitha, Won, Helen, Wong, Wai, Berger, Mike, de Stanchina, Elisa, Barratt, Derek G., Cosulich, Sabina, Klinowska, Teresa, Rosen, Neal, Shokat, Kevan M.

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Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3―Activating Compound von PETERSON, Quinn P, HSU, Danny C, NOVOTNY, Chris J, WEST, Diana C, KIM, Dewey, SCHMIT, Joanna M, DIRIKOLU, Levent, HERGENROTHER, Paul J, FAN, Timothy M

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Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors von Lazarus, Michael B, Novotny, Chris J, Shokat, Kevan M

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Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K‑Ras von Novotny, Chris J, Hamilton, Gregory L, McCormick, Frank, Shokat, Kevan M

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Dissecting the biology of mTORC1 beyond rapamycin von Yang, Guang, Francis, Deanne, Krycer, James R., Larance, Mark, Zhang, Ziyang, Novotny, Chris J., Diaz-Vegas, Alexis, Shokat, Kevan M., James, David E.

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Overcoming resistance to HER2 inhibitors through state-specific kinase binding von Novotny, Chris J, Pollari, Sirkku, Park, Jin H, Lemmon, Mark A, Shen, Weijun, Shokat, Kevan M

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Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3 von Peterson, Quinn P., Hsu, Danny C., Goode, David R., Novotny, Chris J., Totten, Ryan K., Hergenrother, Paul J.

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Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1) von Hsu, Danny C, Roth, Howard S, West, Diana C, Botham, Rachel C, Novotny, Chris J, Schmid, Steven C, Hergenrother, Paul J

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Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs von Lucas, Pamela W., Schmit, Joanna M., Peterson, Quinn P., West, Diana C., Hsu, Danny C., Novotny, Chris J., Dirikolu, Levent, Churchwell, Mona I., Doerge, Daniel R., Garrett, Laura D., Hergenrother, Paul J., Fan, Timothy M.

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Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening von Novotny, Chris J., Pollari, Sirkku, Park, Jin H., Lemmon, Mark A., Schultz, Peter G., Shen, Weijun, Shokat, Kevan M.

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Discovery and Canine Preclinical Assessment of a Non-Toxic Procaspase-3-Activating Compound von Peterson, Quinn P., Hsu, Danny C., Novotny, Chris J., West, Diana C., Kim, Dewey, Schmit, Joanna M., Dirikolu, Levent, Hergenrother, Paul J., Fan, Timothy M.

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Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1 in healthy dogs von Lucas, Pamela W., Schmit, Joanna M., Peterson, Quinn P., West, Diana C., Hsu, Danny C., Novotny, Chris J., Dirikolu, Levent, Deorge, Daniel R., Garrett, Laura D., Hergenrother, Paul J., Fan, Timothy M.

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DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS von PETERSON, QUINN PATRICK, WEST, DIANA C, HERGENROTHER, PAUL JOSEPH, HSU, DANNY CHUNG, NOVOTNY, CHRIS J, FAN, TIMOTHY M

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Procaspase activating compounds von Hergenrother Paul J, Fan Timothy M, West Diana C, Peterson Quinn Patrick, Novotny Chris J, Hsu Danny Chung

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DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS von FAN, Timothy M, HERGENROTHER, Paul Joseph, NOVOTNY, Chris J, PETERSON, Quinn Patrick, HSU, Danny Chung, WEST, Diana C

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Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs von PETERSON, QUINN PATRICK, WEST, DIANA C, HERGENROTHER, PAUL JOSEPH, HSU, DANNY CHUNG, NOVOTNY, CHRIS J, FAN, TIMOTHY M

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projeto, síntese e avaliação de compostos ativadores de procaspase como fármacos anticâncer personalizados von PAUL JOSEPH HERGENROTHER, CHRIS J. NOVOTNY, DIANA C. WEST, QUINN PATRICK PETERSON, TIMOTHY M. FAN, DANNY CHUNG HSU

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PROCASPASE ACTIVATING COMPOUNDS von FAN TIMOTHY M, HERGENROTHER PAUL J, PETERSON QUINN PATRICK, WEST DIANA C, NOVOTNY CHRIS J, HSU DANNY CHUNG

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Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs von FAN TIMOTHY M, HERGENROTHER PAUL J, PETERSON QUINN PATRICK, WEST DIANA C, NOVOTNY CHRIS J, HSU DANNY CHUNG

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