Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts von Patil, Satish, Lis, Lev G, Schumacher, Robert J, Norris, Beverly J, Morgan, Monique L, Cuellar, Rebecca A. D, Blazar, Bruce R, Suryanarayanan, Raj, Gurvich, Vadim J, Georg, Gunda I

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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS von Flory, Craig M., Norris, Beverly J., Larson, Nicole A., Coicou, Lia G., Koniar, Brenda L., Mysz, Margaret A., Rich, Timothy P., Ingbar, David H., Schumacher, Robert J.

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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity von Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R. C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi

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Abstract LB078: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) inhibits hormone therapy resistant breast cancer cells, in part by Inhibiting CYP3A4 arachidonic acid epoxygenase activity von Guo, Zhijun, Lei, Jianxun, Hong, Kwon Ho, Norris, Beverly, Flory, Craig M., Jayaraman, Swaathi, McDermott, Connor, Ambrose, Elizabeth, Sevrioukova, Irina, Poulos, Tom, Denisov, Ilia, Sliga, Stephen, Schumacher, Robert J., Georg, Gunda I., Hawse, John R., Goetz, Matthew P., Potter, David A.

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria von Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O'Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda I., Ambrose, Elizabeth, Potter, David A.

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Abstract LB102: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral r... von Guo, Zhijun, Lei, Jianxun, Venkatesh, Hrishi, Owen, David, Bass, Adam, Cannon, Christine, McCarra, Joshua, Koniar, Brenda, Flory, Craig, Norris, Beverly, Schumacher, Robert J., Jayaraman, Swaathi, Hawse, John, Antonarakis, Emmanuel S., Petricoin, Emanuel F., Wulfkuhle, Julia, Cardiff, Robert D., Ambrose, Elizabeth A., Georg, Gunda I., Schwertfeger, Kaylee L., Farrar, Michael A., Croix, Brad St, Goetz, Matthew P., Potter, David A.

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Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- brea... von Guo, Zhijun, Sevrioukova, Irina, Hanse, Eric, Zhang, Xia, Denisov, Ilia, Chiu, Ting-Lan, Cuellar, Rebecca, Torres, Christian, Wulfkuhle, Julia, Petricoin, Emanuel, Cao, Qing, Chu, Haitao, Norris, Beverly, Schumacher, Robert, Kelekar, Ameeta, Blair, Ian, Capdevila, Jorge, Falck, John, Poulos, Thomas, Sligar, Steven, Georg, Gunda, Amin, Elizabeth, Potter, David A.

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria von Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O’Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda I., Ambrose, Elizabeth, Potter, David A.

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Abstract 82: CYP3A4 promotes mammary carcinoma angiogenesis in a cell iIntrinsic fashion von Guo, Zhijun, Norris, Beverly, Henriksen, Jonathan, Morgan, Monique, Maher, Michael, Schumacher, Robert, Bliss, Robin, Chu, Haitao, Gupta, Kalpna, Schmechel, Stephen, Potter, David

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Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides von Guo, Zhijun, Sevrioukova, Irina F., Hanse, Eric, Denisov, Ilia, Zhang, Xia, Chiu, Ting-Lan, Swedien, Daniel, Stamschror, Justin, Alvarez, Juan, Ortiz, William Marerro, Morgan, Monique, Maher, Michael, Chavez, Kathryn J., Thomas, Dafydd, Bae, Young Kyung, Henriksen, Jonathan, Norris, Beverly, Schumacher, Robert J., Wang, Henry, Bliss, Robin, Chu, Haitao, Cuellar, Rebecca, Poulos, Thomas L., Sligar, Stephen G., Atkins, William, Schmechel, Stephen, Capdevila, Jorge, Falck, John, Blair, Ian, Jones, Jeffrey P., Georg, Gunda, Gupta, Kalpna, Kelekar, Ameeta, Amin, Elizabeth, Potter, David A.

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Abstract 2689: Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide von Guo, Zhijun, Chavez, Kathryn J., Alvarez, Juan, Zhang, Xia, Norris, Beverly, Maher, Michael, Morgan, Monique, Schumacher, Robert J., Cuellar, Rebecca, Sevrioukova, Irina F., Poulos, Thomas L., Denisov, Ilia, Sligar, Stephen G., Gupta, Kalpna, Blair, Ian A., Capdevila, Jorge, Kelekar, Ameeta, Amin, Elizabeth, Georg, Gunda, Potter, David A.

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Robust Progenitor T-Cell Production From Human Hematopoietic Progenitor Cell Expanded with Stemregenin-1 von Stefanski, Heather, Singh, Jastaranpreet, Norris, Beverly, Schumacher, Robert, Wagner, John E., Blazar, Bruce R., Zuniga-Pflucker, Juan Carlos

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519 - Robust Progenitor T-Cell Production From Human Hematopoietic Progenitor Cell Expanded with Stemregenin-1 von Stefanski, Heather, Singh, Jastaranpreet, Norris, Beverly, Schumacher, Robert, Wagner, John E., Blazar, Bruce R., Zuniga-Pflucker, Juan Carlos

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A framework for evaluating safety in design von Norris, Beverly

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Enzymatic assays for 2-deoxyglucose and 2-deoxyglucose 6-phosphate von Chi, Maggie M.-Y., Pusateri, Mary Ellen, Carter, Joyce G., Norris, Beverly J., McDougal, David B., Lowry, Oliver H.

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Method and system for the production of cells and cell products and applications thereof von Hirschel, Mark, Crep, Martin Peder, Page, Darrell P, Bongers, Karl Patrick, Adams, Grant, Gramer, Michael J, Wong, Thiem Chan Duong, Norris, Beverly, Waniger, Scott, Wojciechowski, Robert J

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FREMGANGSMÅDE OG SYSTEM TIL CELLEPRODUKTION von PAGE, Darrell, Paul, WOJCIECHOWSKI, Robert, J, BONGERS, Karl, Patrick, WANIGER, Scott, Thomas, ADAMS, Grant, GRAMER, Michael, John, NORRIS, Beverly, CREP, Martin, Peder, WONG, Thiem Chan Duong, HIRSCHEL, Mark, D

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METHOD AND SYSTEM FOR THE PRODUCTION OF CELLS von PAGE, Darrell, Paul, WOJCIECHOWSKI, Robert, J, BONGERS, Karl, Patrick, WANIGER, Scott, Thomas, ADAMS, Grant, GRAMER, Michael, John, NORRIS, Beverly, CREP, Martin, Peder, WONG, Thiem Chan Duong, HIRSCHEL, Mark, D

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METHOD AND SYSTEM FOR THE PRODUCTION OF CELLS AND CELL PRODUCTS AND APPLICATIONS THEREOF von WOJCIECHOWSKI ROBERT J, NORRIS BEVERLY, WONG THIEM CHAN DUONG, HIRSCHEL MARK, BONGERS KARL PATRICK, WANIGER SCOTT, ADAMS GRANT, GRAMER MICHAEL J, PAGE DARRELL P, CREP MARTIN PEDER

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Method and system for the production of cells and cell products and applications thereof von Norris Beverly, Hirschel Mark, Wojciechowski Robert J, Crep Martin Peder, Gramer Michael J, Adams Grant, Waniger Scott, Page Darrell P, Bongers Karl Patrick, Wong Thiem Chan Duong

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