Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action von Karagöz, G. Elif, Duarte, Afonso M.S., Akoury, Elias, Ippel, Hans, Biernat, Jacek, Morán Luengo, Tania, Radli, Martina, Didenko, Tatiana, Nordhues, Bryce A., Veprintsev, Dmitry B., Dickey, Chad A., Mandelkow, Eckhard, Zweckstetter, Markus, Boelens, Rolf, Madl, Tobias, Rüdiger, Stefan G.D.

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Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency von Sabbagh, Jonathan J, O'Leary, 3rd, John C, Blair, Laura J, Klengel, Torsten, Nordhues, Bryce A, Fontaine, Sarah N, Binder, Elisabeth B, Dickey, Chad A

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Hsp90 activator Aha1 drives production of pathological tau aggregates von Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.

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Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation von Abisambra, Jose F, Jinwal, Umesh K, Blair, Laura J, O'Leary, 3rd, John C, Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E, Zhang, Bo, Nordhues, Bryce A, Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A, Dickey, Chad A

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau von Blair, Laura J, Nordhues, Bryce A, Hill, Shannon E, Scaglione, K Matthew, O'Leary, 3rd, John C, Fontaine, Sarah N, Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L, Muschol, Martin, Uversky, Vladimir N, Klengel, Torsten, Binder, Elisabeth B, Kayed, Rakez, Golde, Todd E, Berchtold, Nicole, Dickey, Chad A

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Human cyclophilin 40 unravels neurotoxic amyloids von Baker, Jeremy D, Shelton, Lindsey B, Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A, Darling, April, Sullivan, Leia E, Sun, Zheying, Solanki, Parth K, Martin, Mackenzie D, Suntharalingam, Amirthaa, Sabbagh, Jonathan J, Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N, Zweckstetter, Markus, Dickey, Chad A, Koren, 3rd, John, Blair, Laura J

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DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins von Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens Jr, Stanley M, Dickey, Chad A

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The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein von Taylor, Isabelle R., Ahmad, Atta, Wu, Taia, Nordhues, Bryce A., Bhullar, Anup, Gestwicki, Jason E., Zuiderweg, Erik R.P.

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Imbalance of Hsp70 family variants fosters tau accumulation von Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.

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Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD von Sabbagh, Jonathan J, Cordova, Ricardo A, Zheng, Dali, Criado-Marrero, Marangelie, Lemus, Andrea, Li, Pengfei, Baker, Jeremy D, Nordhues, Bryce A, Darling, April L, Martinez-Licha, Carlos, Rutz, Daniel A, Patel, Shreya, Buchner, Johannes, Leahy, James W, Koren, John, Dickey, Chad A, Blair, Laura J

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Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy von Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A

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Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma von Stothert, Andrew R., Suntharalingam, Amirthaa, Tang, Xiaolan, Crowley, Vincent M., Mishra, Sanket J., Webster, Jack M., Nordhues, Bryce A., Huard, Dustin J. E., Passaglia, Christopher L., Lieberman, Raquel L., Blagg, Brian S. J., Blair, Laura J., Koren, John, Dickey, Chad A.

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NMR Characterization of the Interaction of the Salmonella Type III Secretion System Protein SipD and Bile Salts von Wang, Yu, Nordhues, Bryce A, Zhong, Dalian, De Guzman, Roberto N

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Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis von Selenica, Maj-Linda B, Davtyan, Hayk, Housley, Steven B, Blair, Laura J, Gillies, Anne, Nordhues, Bryce A, Zhang, Bo, Liu, Joseph, Gestwicki, Jason E, Lee, Daniel C, Gordon, Marcia N, Morgan, Dave, Dickey, Chad A

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The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate von Chatterjee, Srirupa, Zhong, Dalian, Nordhues, Bryce A., Battaile, Kevin P., Lovell, Scott, De Guzman, Roberto N.

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Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement von Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R.P., Gestwicki, Jason E., Dickey, Chad A.

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Nuclear Magnetic Resonance Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa von Chaudhury, Sukanya, Nordhues, Bryce A, Kaur, Kawaljit, Zhang, Na, De Guzman, Roberto N

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The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling von Blair, Laura J, Criado-Marrero, Marangelie, Zheng, Dali, Wang, Xinming, Kamath, Siddharth, Nordhues, Bryce A, Weeber, Edwin J, Dickey, Chad A

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The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics von Fontaine, Sarah N, Martin, Mackenzie D, Akoury, Elias, Assimon, Victoria A, Borysov, Sergiy, Nordhues, Bryce A, Sabbagh, Jonathan J, Cockman, Matt, Gestwicki, Jason E, Zweckstetter, Markus, Dickey, Chad A

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Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules von Martin, Mackenzie D, Baker, Jeremy D, Suntharalingam, Amirthaa, Nordhues, Bryce A, Shelton, Lindsey B, Zheng, Dali, Sabbagh, Jonathan J, Haystead, Timothy A.J, Gestwicki, Jason E, Dickey, Chad A

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