Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism von Cabreiro, Filipe, Au, Catherine, Leung, Kit-Yi, Vergara-Irigaray, Nuria, Cochemé, Helena M., Noori, Tahereh, Weinkove, David, Schuster, Eugene, Greene, Nicholas D.E., Gems, David

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Lipid order and charge protect killer T cells from accidental death von Rudd-Schmidt, Jesse A., Hodel, Adrian W., Noori, Tahereh, Lopez, Jamie A., Cho, Hyun-Jung, Verschoor, Sandra, Ciccone, Annette, Trapani, Joseph A., Hoogenboom, Bart W., Voskoboinik, Ilia

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Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma von Flinsenberg, Thijs W H, Tromedjo, Charnelle C, Hu, Nan, Liu, Ye, Guo, Yin, Thia, Kevin Y T, Noori, Tahereh, Song, Xiaomin, Aw Yeang, Han X, Tantalo, Daniela G, Handunnetti, Sasanka, Seymour, John F, Roberts, Andrew W, Ritchie, David, Koldej, Rachel, Neeson, Paul J, Wang, Lai, Trapani, Joseph A, Tam, Constantine S, Voskoboinik, Ilia

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ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse von Rudd-Schmidt, Jesse A, Laine, Romain F, Noori, Tahereh, Brennan, Amelia J, Voskoboinik, Ilia

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NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation von Lelliott, Emily J., Ramsbottom, Kelly M., Dowling, Mark R., Shembrey, Carolyn, Noori, Tahereh, Kearney, Conor J., Michie, Jessica, Parish, Ian A., Jordan, Margaret A., Baxter, Alan G., Young, Neil D., Brennan, Amelia J., Oliaro, Jane

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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells von Sutton, Vivien R, Watt, Sally V, Akhlaghi, Hedieh, Cipolla, David C, Chen, Kuan-Ju, LaSala, Daniel, McDonald, Patrick P, Beavis, Paul A, Munoz, Isabelle, Hodel, Adrian W, Noori, Tahereh, Voskoboinik, Ilia, Trapani, Joseph A

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Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing von Lopez, Jamie A, Noori, Tahereh, Minson, Adrian, Li Jovanoska, Lu, Thia, Kevin, Hildebrand, Michael S, Akhlaghi, Hedieh, Darcy, Phillip K, Kershaw, Michael H, Brown, Natasha J, Grigg, Andrew, Trapani, Joseph A, Voskoboinik, Ilia

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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity von Burr, Marian L., Sparbier, Christina E., Chan, Yih-Chih, Williamson, James C., Woods, Katherine, Beavis, Paul A., Lam, Enid Y. N., Henderson, Melissa A., Bell, Charles C., Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W., Bassik, Michael C., Neeson, Paul J., Behren, Andreas, Darcy, Phillip K., Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A., Cebon, Jonathan, Lehner, Paul J., Dawson, Mark A.

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Acidic pH can attenuate immune killing through inactivation of perforin von Hodel, Adrian W, Rudd-Schmidt, Jesse A, Noori, Tahereh, Lupton, Christopher J, Cheuk, Veronica C T, Trapani, Joseph A, Hoogenboom, Bart W, Voskoboinik, Ilia

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A cell-based functional assay that accurately links genotype to phenotype in familial HLH von Noori, Tahereh, Rudd-Schmidt, Jesse A., Kane, Alisa, Frith, Katie, Gray, Paul E., Hu, Hannah, Hsu, Danny, Chung, Clara W. T., Hodel, Adrian W., Trapani, Joseph A., Voskoboinik, Ilia

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Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization von Brasacchio, Daniella, Alsop, Amber E, Noori, Tahereh, Lufti, Mariam, Iyer, Sweta, Simpson, Kaylene J, Bird, Phillip I, Kluck, Ruth M, Johnstone, Ricky W, Trapani, Joseph A

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Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1 von Castiblanco, Daniela, Rudd-Schmidt, Jesse A., Noori, Tahereh, Sutton, Vivien R., Hung, Ya Hui, Flinsenberg, Thijs W.H., Hodel, Adrian W., Young, Neil D., Smith, Nicholas, Bratkovic, Drago, Peters, Heidi, Walterfang, Mark, Trapani, Joseph A., Brennan, Amelia J., Voskoboinik, Ilia

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Filaggrin-Associated Atopic Skin, Eye, Airways, and Gut Disease, Modifying the Presentation of X-Linked Reticular Pigmentary Disorder (XLPDR) von Li, Margaret W. Y., Burnett, Leslie, Dai, Pei, Avery, Danielle T., Noori, Tahereh, Voskoboinik, Ilia, Shah, Parth R., Tatian, Artiene, Tangye, Stuart G., Gray, Paul E., Ma, Cindy S.

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Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer von Brasacchio, Daniella, Busuttil, Rita A., Noori, Tahereh, Johnstone, Ricky W., Boussioutas, Alex, Trapani, Joseph A.

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Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis von Jang, Helena S., Flinsenberg, Thijs W. H., Lacaze, Paul, Thia, Kevin Y. T., Noori, Tahereh, Fernando, Suran L., Kerridge, Ian, Riaz, Moeen, McNeil, John J., Blombery, Piers A., Trapani, Joseph A., Voskoboinik, Ilia

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Recovery of natural killer cell cytotoxicity in a A91V perforinhomozygous patient following severe haemophagocytic lymphohistiocytosis von Jang, Helena S., Flinsenberg, Thijs W. H., Lacaze, Paul, Thia, Kevin Y. T., Noori, Tahereh, Fernando, Suran L., Kerridge, Ian, Riaz, Moeen, McNeil, John J., Blombery, Piers A., Trapani, Joseph A., Voskoboinik, Ilia

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Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome von Opat, Stephen, Hearps, Anna C., Thia, Kevin, Yuen, Agnes, Rogers, Ben, Chachage, Mkunde, Moore, Gregory, Shortt, Jake, Ryland, Georgina, Blombery, Piers, Schwarer, Anthony P., Noori, Tahereh, Trapani, Joseph A., Jaworowski, Anthony, Voskoboinik, Ilia

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Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin von Brennan, Amelia J., Law, Ruby H. P., Conroy, Paul J., Noori, Tahereh, Lukoyanova, Natalya, Saibil, Helen, Yagita, Hideo, Ciccone, Annette, Verschoor, Sandra, Whisstock, James C., Trapani, Joseph A., Voskoboinik, Ilia

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Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome von Opat, Stephen, Hearps, Anna C, Thia, Kevin, Yuen, Agnes, Rogers, Ben, Chachage, Mkunde, Moore, Gregory, Shortt, Jake, Ryland, Georgina, Blombery, Piers, Schwarer, Anthony P, Noori, Tahereh, Trapani, Joseph A, Jaworowski, Anthony, Voskoboinik, Ilia

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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity von Burr, Marian L, Sparbier, Christina E, Chan, Yih-Chih, Williamson, James C, Woods, Katherine, Beavis, Paul A, Lam, Enid Y. N, Henderson, Melissa A, Bell, Charles C, Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W, Bassik, Michael C, Neeson, Paul J, Behren, Andreas, Darcy, Phillip K, Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A, Cebon, Jonathan, Lehner, Paul J, Dawson, Mark A

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