Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2 von Alessi, Dario R, Gray, Nathanael S, Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P, Nomanbhoy, Tyzoon K

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ERK5 kinase activity is dispensable for cellular immune response and proliferation von Lin, Emme C. K., Amantea, Christopher M., Nomanbhoy, Tyzoon K., Weissig, Helge, Ishiyama, Junichi, Hu, Yi, Sidique, Shyama, Li, Bei, Kozarich, John W., Rosenblum, Jonathan S.

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Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates von Patricelli, Matthew P, Szardenings, A. Katrin, Liyanage, Marek, Nomanbhoy, Tyzoon K, Wu, Min, Weissig, Helge, Aban, Arwin, Chun, Doris, Tanner, Stephen, Kozarich, John W

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor von Johnson, Douglas S, Stiff, Cory, Lazerwith, Scott E, Kesten, Suzanne R, Fay, Lorraine K, Morris, Mark, Beidler, David, Liimatta, Marya B, Smith, Sarah E, Dudley, David T, Sadagopan, Nalini, Bhattachar, Shobha N, Kesten, Stephen J, Nomanbhoy, Tyzoon K, Cravatt, Benjamin F, Ahn, Kay

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Functional interrogation of kinases and other nucleotide-binding proteins von Rosenblum, Jonathan S., Nomanbhoy, Tyzoon K., Kozarich, John W.

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Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma von Matthews, Julie Marie, Bhatt, Shruti, Patricelli, Matthew P., Nomanbhoy, Tyzoon K., Jiang, Xiaoyu, Natkunam, Yasodha, Gentles, Andrew J., Martinez, Ezequiel, Zhu, Daxing, Chapman, Jennifer Rose, Cortizas, Elena, Shyam, Ragini, Chinichian, Shideh, Advani, Ranjana, Tan, Li, Zhang, Jianming, Choi, Hwan Geun, Tibshirani, Robert, Buhrlage, Sara J., Gratzinger, Dita, Verdun, Ramiro, Gray, Nathanael S., Lossos, Izidore S.

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High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity von Zhu, Wen, Radadiya, Ashish, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi, Rice, David W., Takagi, Yuichiro, Richards, Nigel G. J.

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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pa... von Ahn, Kay, Smith, Sarah E, Liimatta, Marya B, Beidler, David, Sadagopan, Nalini, Dudley, David T, Young, Tim, Wren, Paul, Zhang, Yanhua, Swaney, Steven, Van Becelaere, Keri, Blankman, Jacqueline L, Nomura, Daniel K, Bhattachar, Shobha N, Stiff, Cory, Nomanbhoy, Tyzoon K, Weerapana, Eranthie, Johnson, Douglas S, Cravatt, Benjamin F

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Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response von Nomanbhoy, Tyzoon K, Sharma, Geeta, Brown, Heidi, Wu, Jiangyue, Aban, Arwin, Vogeti, Subha, Alemayehu, Senait, Sykes, Maria, Rosenblum, Jonathan S, Kozarich, John W

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Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase‑6 von Okerberg, Eric S, Dagbay, Kevin B, Green, Jennifer L, Soni, Ishankumar, Aban, Arwin, Nomanbhoy, Tyzoon K, Savinov, Sergey N, Hardy, Jeanne A, Kozarich, John W

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Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity von Ahn, Kyunghye, Johnson, Douglas S, Fitzgerald, Laura R, Liimatta, Marya, Arendse, Andrea, Stevenson, Tracy, Lund, Eric. T, Nugent, Richard A, Nomanbhoy, Tyzoon K, Alexander, Jessica P, Cravatt, Benjamin F

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Discovery of Potent and Selective Covalent Inhibitors of JNK von Zhang, Tinghu, Inesta-Vaquera, Francisco, Niepel, Mario, Zhang, Jianming, Ficarro, Scott B., Machleidt, Thomas, Xie, Ting, Marto, Jarrod A., Kim, NamDoo, Sim, Taebo, Laughlin, John D., Park, Hajeung, LoGrasso, Philip V., Patricelli, Matt, Nomanbhoy, Tyzoon K., Sorger, Peter K., Alessi, Dario R., Gray, Nathanael S.

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In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases von Patricelli, Matthew P., Nomanbhoy, Tyzoon K., Wu, Jiangyue, Brown, Heidi, Zhou, David, Zhang, Jianming, Jagannathan, Subadhra, Aban, Arwin, Okerberg, Eric, Herring, Chris, Nordin, Brian, Weissig, Helge, Yang, Qingkai, Lee, Jiing-Dwan, Gray, Nathanael S., Kozarich, John W.

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Blocking Site-to-Site Translocation of a Misactivated Amino Acid by Mutation of a Class I tRNA Synthetase von Bishop, Anthony C., Nomanbhoy, Tyzoon K., Schimmel, Paul

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Mutational Separation of Two Pathways for Editing by a Class I tRNA Synthetase von Hendrickson, Tamara L, Nomanbhoy, Tyzoon K, de Crécy-Lagard, Valérie, Fukai, Shuya, Nureki, Osamu, Yokoyama, Shigeyuki, Schimmel, Paul

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C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases von Rosen, Michael K, Gosser, Yuying Q, Nomanbhoy, Tyzoon K, Aghazadeh, Behzad, Manor, Danny, Combs, Carolyn, Cerione, Richard A

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ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement von Nordin, Brian E, Liu, Yongsheng, Aban, Arwin, Brown, Heidi E, Wu, Jiangyue, Hainley, Anna K, Rosenblum, Jonathan S, Nomanbhoy, Tyzoon K, Kozarich, John W

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Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH) von Johnson, Douglas S., Ahn, Kay, Kesten, Suzanne, Lazerwith, Scott E., Song, Yuntao, Morris, Mark, Fay, Lorraine, Gregory, Tracy, Stiff, Cory, Dunbar, James B., Liimatta, Marya, Beidler, David, Smith, Sarah, Nomanbhoy, Tyzoon K., Cravatt, Benjamin F.

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Abstract 225: Chemoproteomic evaluation of target engagement in clinical samples von Nomanbhoy, Tyzoon K.

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Misactivated Amino Acids Translocate at Similar Rates across Surface of a tRNA Synthetase von Nomanbhoy, Tyzoon K., Schimmel, Paul R.

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