Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase von Gupta, Kushol, Turkki, Vesa, Sherrill-Mix, Scott, Hwang, Young, Eilers, Grant, Taylor, Louis, McDanal, Charlene, Wang, Ping, Temelkoff, David, Nolte, Robert T, Velthuisen, Emile, Jeffrey, Jerry, Van Duyne, Gregory D, Bushman, Frederic D

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Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics von DeAnda, Felix, Hightower, Kendra E, Nolte, Robert T, Hattori, Kazunari, Yoshinaga, Tomokazu, Kawasuji, Takashi, Underwood, Mark R

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor R... von Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A

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Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop von Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, Young, Jasmine

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The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors von Wood, Edgar R., Bledsoe, Randy, Chai, Jing, Daka, Philias, Deng, Hongfeng, Ding, Yun, Harris-Gurley, Sarah, Kryn, Luz Helena, Nartey, Eldridge, Nichols, James, Nolte, Robert T., Prabhu, Ninad, Rise, Cecil, Sheahan, Timothy, Shotwell, J. Brad, Smith, Danielle, Tai, Vince, Taylor, J. David, Tomberlin, Ginger, Wang, Liping, Wisely, Bruce, You, Shihyun, Xia, Bing, Dickson, Hamilton

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Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold von Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert

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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors von Peese, Kevin M, Allard, Christopher W, Connolly, Timothy, Johnson, Barry L, Li, Chen, Patel, Manoj, Sorensen, Margaret E, Walker, Michael A, Meanwell, Nicholas A, McAuliffe, Brian, Minassian, Beatrice, Krystal, Mark, Parker, Dawn D, Lewis, Hal A, Kish, Kevin, Zhang, Ping, Nolte, Robert T, Simmermacher, Jean, Jenkins, Susan, Cianci, Christopher, Naidu, B. Narasimhulu

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Rational Design of Potent Non-Nucleoside Inhibitors of HIV‑1 Reverse Transcriptase von Chong, Pek, Sebahar, Paul, Youngman, Michael, Garrido, Dulce, Zhang, Huichang, Stewart, Eugene L., Nolte, Robert T., Wang, Liping, Ferris, Robert G., Edelstein, Mark, Weaver, Kurt, Mathis, Amanda, Peat, Andrew

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Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains von Gupta, Kushol, Brady, Troy, Dyer, Benjamin M, Malani, Nirav, Hwang, Young, Male, Frances, Nolte, Robert T, Wang, Liping, Velthuisen, Emile, Jeffrey, Jerry, Van Duyne, Gregory D, Bushman, Frederic D

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Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors von Hasegawa, Masaichi, Nishigaki, Naohiko, Washio, Yoshiaki, Kano, Kazuya, Harris, Philip A, Sato, Hideyuki, Mori, Ichiro, West, Rob I, Shibahara, Megumi, Toyoda, Hiroko, Wang, Liping, Nolte, Robert T, Veal, James M, Cheung, Mui

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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis von Harris, Philip A, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Finger, Joshua N, Hoffman, Sandra J, Kahler, Kirsten M, Lehr, Ruth, Lich, John D, Nagilla, Rakesh, Nolte, Robert T, Ouellette, Michael T, Pao, Christina S, Schaeffer, Michelle C, Smallwood, Angela, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Marquis, Robert W, Bertin, John, Gough, Peter J

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Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction von Phelan, Caroline A, Gampe, Robert T, Lambert, Millard H, Parks, Derek J, Montana, Valerie, Bynum, Jane, Broderick, Timothy M, Hu, Xiao, Williams, Shawn P, Nolte, Robert T, Lazar, Mitchell A

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ von Milburn, Michael V, Nolte, Robert T, Wisely, G. Bruce, Westin, Stefan, Cobb, Jeffery E, Lambert, Millard H, Kurokawa, Riki, Rosenfeld, Michael G, Willson, Timothy M, Glass, Christopher K

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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR α von Xu, H. Eric, Stanley, Thomas B, Montana, Valerie G, Lambert, Millard H, Shearer, Barry G, Cobb, Jeffery E, McKee, David D, Galardi, Cristin M, Plunket, Kelli D, Nolte, Robert T, Parks, Derek J, Moore, John T, Kliewer, Steven A, Willson, Timothy M, Stimmel, Julie B

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Novel 4-amino-furo[2,3- d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors von Miyazaki, Yasushi, Matsunaga, Shinichiro, Tang, Jun, Maeda, Yutaka, Nakano, Masato, Philippe, Rocher J., Shibahara, Megumi, Liu, Wei, Sato, Hideyuki, Wang, Liping, Nolte, Robert T.

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X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation von Wang, Liping, Zuercher, William J., Consler, Thomas G., Lambert, Millard H., Miller, Aaron B., Orband-Miller, Lisa A., McKee, David D., Willson, Timothy M., Nolte, Robert T.

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Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity von Xu, Robert X., Hassell, Anne M., Vanderwall, Dana, Lambert, Millard H., Holmes, William D., Luther, Michael A., Rocque, Warren J., Milburn, Michael V., Zhao, Yingdong, Ke, Hengming, Nolte, Robert T.

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BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution von Pearce, Kenneth H., Overton, Laurie K., Gampe, Robert T., Barrett, George B., Taylor, J. David, McKee, David D., Campobasso, Nino, Nolte, Robert T., Reid, Robert A.

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Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators von Glass, Christopher K, Westin, Stefan, Kurokawa, Riki, Nolte, Robert T, Wisely, G. Bruce, McInerney, Eileen M, Rose, David W, Milburn, Michael V, Rosenfeld, Michael G

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