Checkpoint Inhibition in Bladder Cancer: Clinical Expectations, Current Evidence, and Proposal of Future Strategies Based on a Tumor-Specific Immunobiological Approach von Mancini, Mariangela, Righetto, Marialaura, Noessner, Elfriede

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Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation von Mendler, Anna N., Hu, Bin, Prinz, Petra U., Kreutz, Marina, Gottfried, Eva, Noessner, Elfriede

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Collagen density regulates the activity of tumor-infiltrating T cells von Kuczek, Dorota E, Larsen, Anne Mette H, Thorseth, Marie-Louise, Carretta, Marco, Kalvisa, Adrija, Siersbæk, Majken S, Simões, Ana Micaela C, Roslind, Anne, Engelholm, Lars H, Noessner, Elfriede, Donia, Marco, Svane, Inge Marie, Straten, Per Thor, Grøntved, Lars, Madsen, Daniel H

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T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice von Quitt, Oliver, Luo, Shanshan, Meyer, Marten, Xie, Zhe, Golsaz-Shirazi, Forough, Loffredo-Verde, Eva, Festag, Julia, Bockmann, Jan Hendrik, Zhao, Lili, Stadler, Daniela, Chou, Wen-Min, Tedjokusumo, Raindy, Wettengel, Jochen Martin, Ko, Chunkyu, Noeßner, Elfriede, Bulbuc, Nadja, Shokri, Fazel, Lüttgau, Sandra, Heikenwälder, Mathias, Bohne, Felix, Moldenhauer, Gerhard, Momburg, Frank, Protzer, Ulrike

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Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer von Hänze, Jörg, Wegner, Moritz, Noessner, Elfriede, Hofmann, Rainer, Hegele, Axel

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A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas von Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

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Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities von Chu, Chang-Feng, Sabath, Florian, Fibi-Smetana, Silvia, Sun, Shan, Öllinger, Rupert, Noeßner, Elfriede, Chao, Ying-Yin, Rinke, Linus, Winheim, Elena, Rad, Roland, Krug, Anne B., Taher, Leila, Zielinski, Christina E.

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Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing von Fischbeck, Angelika J, Ruehland, Svenja, Ettinger, Andreas, Paetzold, Kerstin, Masouris, Ilias, Noessner, Elfriede, Mendler, Anna N

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Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens von Holmen Olofsson, Gitte, Idorn, Manja, Carnaz Simões, Ana Micaela, Aehnlich, Pia, Skadborg, Signe Koggersbøl, Noessner, Elfriede, Debets, Reno, Moser, Bernhard, Met, Özcan, thor Straten, Per

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Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy von Olguín-Contreras, Luis Felipe, Mendler, Anna N, Popowicz, Grzegorz, Hu, Bin, Noessner, Elfriede

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Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy von Schlenker, Ramona, Olguín-Contreras, Luis Felipe, Leisegang, Matthias, Schnappinger, Julia, Disovic, Anja, Rühland, Svenja, Nelson, Peter J, Leonhardt, Heinrich, Harz, Hartmann, Wilde, Susanne, Schendel, Dolores J, Uckert, Wolfgang, Willimsky, Gerald, Noessner, Elfriede

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Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease von Kammerl, Ilona E, Dann, Angela, Mossina, Alessandra, Brech, Dorothee, Lukas, Christina, Vosyka, Oliver, Nathan, Petra, Conlon, Thomas M, Wagner, Darcy E, Overkleeft, Hermen S, Prasse, Antje, Rosas, Ivan O, Straub, Tobias, Krauss-Etschmann, Susanne, Königshoff, Melanie, Preissler, Gerhard, Winter, Hauke, Lindner, Michael, Hatz, Rudolf, Behr, Jürgen, Heinzelmann, Katharina, Yildirim, Ali Ö, Noessner, Elfriede, Eickelberg, Oliver, Meiners, Silke

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A Lysine Residue at the C-Terminus of MHC Class I Ligands Correlates with Low C-Terminal Proteasomal Cleavage Probability von Schmalen, Adrian, Kammerl, Ilona E, Meiners, Silke, Noessner, Elfriede, Deeg, Cornelia A, Hauck, Stefanie M

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A novel role of MMP-13 for murine DC function: its inhibition dampens T-cell activation von Bartmann, Juliane, Frankenberger, Marion, Neurohr, Claus, Eickelberg, Oliver, Noessner, Elfriede, von Wulffen, Werner

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Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling von Bendz, Henriette, Ruhland, Sibylle C., Pandya, Maya J., Hainzl, Otmar, Riegelsberger, Stefan, Braüchle, Christoph, Mayer, Matthias P., Buchner, Johannes, Issels, Rolf D., Noessner, Elfriede

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Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function von Gassmann, Hendrik, Schneider, Kira, Evdokimova, Valentina, Ruzanov, Peter, Schober, Sebastian J., Xue, Busheng, von Heyking, Kristina, Thiede, Melanie, Richter, Guenther H. S., Pfaffl, Michael W., Noessner, Elfriede, Stein, Lincoln D., Sorensen, Poul H., Burdach, Stefan E. G., Thiel, Uwe

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CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity von Modak, Madhura, Mattes, Ann-Kathrin, Reiss, Daniela, Skronska-Wasek, Wioletta, Langlois, Rebecca, Sabarth, Nicolas, Konopitzky, Renate, Ramirez, Fidel, Lehr, Katharina, Mayr, Tobias, Kind, David, Viollet, Coralie, Swee, Lee Kim, Petschenka, Jutta, El Kasmi, Karim C, Noessner, Elfriede, Kitt, Kerstin, Pflanz, Stefan

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Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival von Brech, Dorothee, Herbstritt, Anna S., Diederich, Sarah, Straub, Tobias, Kokolakis, Evangelos, Irmler, Martin, Beckers, Johannes, Büttner, Florian A., Schaeffeler, Elke, Winter, Stefan, Schwab, Matthias, Nelson, Peter J., Noessner, Elfriede

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Intratumoral alterations of dendritic-cell differentiation and CD8+ T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma von Noessner, Elfriede, Brech, Dorothee, Mendler, Anna N., Masouris, Ilias, Schlenker, Ramona, Prinz, Petra U.

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Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma - a case report von Issels, Rolf D., Lindner, Lars H., von Bergwelt-Baildon, Michael, Lang, Peter, Rischpler, Christoph, Diem, Heinz, Mosetter, Barbara, Eckl, Judith, Schendel, Dolores J., Salat, Christoph, Stötzer, Oliver, Burdach, Stefan, von Luettichau-Teichert, Irene, Handgretinger, Rupert, Neumann, Jens, Kirchner, Thomas, Steiger, Katja, Boxberg, Melanie, Mansmann, Ulrich, Multhoff, Gabriele, Noessner, Elfriede

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