mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress von Yun, Young Sung, Kim, Kwan Hyun, Tschida, Barbara, Sachs, Zohar, Noble-Orcutt, Klara E., Moriarity, Branden S., Ai, Teng, Ding, Rui, Williams, Jessica, Chen, Liqiang, Largaespada, David, Kim, Do-Hyung

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Synthesis and antileukemic activities of C1–C10-modified parthenolide analogues von Kempema, Aaron M., Widen, John C., Hexum, Joseph K., Andrews, Timothy E., Wang, Dan, Rathe, Susan K., Meece, Frederick A., Noble, Klara E., Sachs, Zohar, Largaespada, David A., Harki, Daniel A.

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Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia von Sachs, Karen, Sarver, Aaron L, Noble-Orcutt, Klara E, LaRue, Rebecca S, Antony, Marie Lue, Chang, Daniel, Lee, Yoonkyu, Navis, Connor M, Hillesheim, Alexandria L, Nykaza, Ian R, Ha, Ngoc A, Hansen, Conner J, Karadag, Fatma K, Bergerson, Rachel J, Verneris, Michael R, Meredith, Matthew M, Schomaker, Matthew L, Linden, Michael A, Myers, Chad L, Largaespada, David A, Sachs, Zohar

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Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line von Kurata, Morito, Antony, Marie Lue, Noble-Orcutt, Klara E, Rathe, Susan K, Lee, Yoonkyu, Furuno, Hidehiro, Ishibashi, Sachiko, Ikeda, Masumi, Yamamoto, Kouhei, Kitagawa, Masanobu, Largaespada, David A, Sachs, Zohar

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Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome von Yun, Hyun Don, Antony, Marie Lue, Linden, Michael A., Noble-Orcutt, Klara E., Eckfeldt, Craig E., Ustun, Celalettin, Nelson, Andrew C., Sachs, Zohar

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NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

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Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML von LaRue, Rebecca S., Noble-Orcutt, Klara E., Hansen, Conner, Ha, Ngoc, Largaespada, David A., Sachs, Zohar

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Abstract 2582: Dose-dependent NRASG12V -mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line von Kurata, Morito, Antony, Marie L., Noble, Klara E., Rathe, Susan K., Hirakouchi, Haruka, Yamamoto, Kouhei, Kitagawa, Masanobu, Sachs, Zohar, Largaespada, David A.

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Single Cell Correlation Analysis: A Novel Method to Analyze Single Cell RNA Sequencing Data Identifies a Self-Renewing Subpopulation of Human Acute Myeloid Leukemia Stem Cells von Lee, Yoonkyu, Wang, Wen, Starr, Timothy K, Noble-Orcutt, Klara E, Myers, Chad L, Sachs, Zohar

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TP53 Altered Acute Myeloid Leukemia Stem Cells Hyperactivate Nuclear Factor-Kappa B von Antony, Marie Lue, Noble-Orcutt, Klara E, Jensen, Jeffrey Lee, He, Fiona, Sachs, Zohar

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Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML von Larue, Rebecca S., Noble, Klara E, Hansen, Conner, Ha, Ngoc, Largaespada, David A, Sachs, Zohar

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Therapeutic Vulnerabilities in Acute Myeloid Leukemia (AML) with TP53 Alterations von Ogunsan, Oluwateniayo, Antony, Marie Lue, Noble-Orcutt, Klara E., He, Fiona, Sachs, Zohar

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Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome von Chang, Daniel, Noble-Orcutt, Klara E, Hudson, Wendy, Iyer, Aishwarya, Pomeroy, Emily, Eckfeldt, Craig E., Sarver, Aaron, Temiz, Nuri Alpay, Linden, Michael, Myers, Chad L, Largaespada, David A., Sachs, Zohar

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Abstract A56: TP53 mutant human AMLs stem cells rely on the proteasome for self-renewal von Antony, Marie Lue, Lee, Yoonkyu, Noble-Orcutt, Klara E, Sachs, Zohar

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Abstract PR09: Single-cell transcriptional profiling of acute myeloid leukemia identifies self-renewing stem cells von Noble-Orcutt, Klara E., Sachs, Karen, Navis, Connor, Hillesheim, Alexandria, Nykaza, Ian, LaRue, Rebecca S., Hansen, Conner, Ha, Ngoc, Linden, Michael A., Largaespada, David A., Sachs, Zohar

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NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

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Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency von Sachs, Zohar, Been, Raha A, DeCoursin, Krista J, Nguyen, Hanh T, Mohd Hassan, Nurul A, Noble-Orcutt, Klara E, Eckfeldt, Craig E, Pomeroy, Emily J, Diaz-Flores, Ernesto, Geurts, Jennifer L, Diers, Miechaleen D, Hasz, Diane E, Morgan, Kelly J, MacMillan, Margaret L, Shannon, Kevin M, Largaespada, David A, Wiesner, Stephen M

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Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome von Yun, Hyun Don, Antony, Marie Lue, Linden, Michael A, Noble-Orcutt, Klara E, Eckfeldt, Craig E, Ustun, Celalettin, Nelson, Andrew C, Sachs, Zohar

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Impact of synthetic and biologic disease‐modifying antirheumatic drugs on antibody responses to the AS03‐adjuvanted pandemic influenza vaccine: A prospective, open‐label, parallel‐... von Gabay, Cem, Bel, Michael, Combescure, Christophe, Ribi, Camillo, Meier, Sara, Posfay‐Barbe, Klara, Grillet, Stéphane, Seebach, Jörg D., Kaiser, Laurent, Wunderli, Werner, Guerne, Pierre‐André, Siegrist, Claire‐Anne

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A Prospective Study of the Factors Shaping Antibody Responses to the AS03‐Adjuvanted Influenza A/H1N1 Vaccine in Cancer Outpatients von Hottinger, Andreas F., George, Anne‐Claude C., Bel, Michael, Favet, Laurence, Combescure, Christophe, Meier, Sara, Grillet, Stéphane, Posfay‐Barbe, Klara, Kaiser, Laurent, Siegrist, Claire‐Anne, Dietrich, Pierre‐Yves

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