Synthesis and antileukemic activities of C1–C10-modified parthenolide analogues von Kempema, Aaron M., Widen, John C., Hexum, Joseph K., Andrews, Timothy E., Wang, Dan, Rathe, Susan K., Meece, Frederick A., Noble, Klara E., Sachs, Zohar, Largaespada, David A., Harki, Daniel A.

Volltext

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress von Yun, Young Sung, Kim, Kwan Hyun, Tschida, Barbara, Sachs, Zohar, Noble-Orcutt, Klara E., Moriarity, Branden S., Ai, Teng, Ding, Rui, Williams, Jessica, Chen, Liqiang, Largaespada, David, Kim, Do-Hyung

Volltext

310 Mechanisms of progression of myelodysplastic syndrome to fatal secondary acute myeloid leukemia von Chang, Daniel, Noble-Orcutt, Klara, Lue Antony, Marie, Largaespada, David, Myers, Chad, Sachs, Zohar

Volltext

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia von Sachs, Karen, Sarver, Aaron L, Noble-Orcutt, Klara E, LaRue, Rebecca S, Antony, Marie Lue, Chang, Daniel, Lee, Yoonkyu, Navis, Connor M, Hillesheim, Alexandria L, Nykaza, Ian R, Ha, Ngoc A, Hansen, Conner J, Karadag, Fatma K, Bergerson, Rachel J, Verneris, Michael R, Meredith, Matthew M, Schomaker, Matthew L, Linden, Michael A, Myers, Chad L, Largaespada, David A, Sachs, Zohar

Volltext

Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line von Kurata, Morito, Antony, Marie Lue, Noble-Orcutt, Klara E, Rathe, Susan K, Lee, Yoonkyu, Furuno, Hidehiro, Ishibashi, Sachiko, Ikeda, Masumi, Yamamoto, Kouhei, Kitagawa, Masanobu, Largaespada, David A, Sachs, Zohar

Volltext

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

Volltext

Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome von Yun, Hyun Don, Antony, Marie Lue, Linden, Michael A., Noble-Orcutt, Klara E., Eckfeldt, Craig E., Ustun, Celalettin, Nelson, Andrew C., Sachs, Zohar

Volltext

Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML von LaRue, Rebecca S., Noble-Orcutt, Klara E., Hansen, Conner, Ha, Ngoc, Largaespada, David A., Sachs, Zohar

Volltext

Abstract 2582: Dose-dependent NRASG12V -mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line von Kurata, Morito, Antony, Marie L., Noble, Klara E., Rathe, Susan K., Hirakouchi, Haruka, Yamamoto, Kouhei, Kitagawa, Masanobu, Sachs, Zohar, Largaespada, David A.

Volltext

Single Cell Correlation Analysis: A Novel Method to Analyze Single Cell RNA Sequencing Data Identifies a Self-Renewing Subpopulation of Human Acute Myeloid Leukemia Stem Cells von Lee, Yoonkyu, Wang, Wen, Starr, Timothy K, Noble-Orcutt, Klara E, Myers, Chad L, Sachs, Zohar

Volltext

Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML von Larue, Rebecca S., Noble, Klara E, Hansen, Conner, Ha, Ngoc, Largaespada, David A, Sachs, Zohar

Volltext

TP53 Altered Acute Myeloid Leukemia Stem Cells Hyperactivate Nuclear Factor-Kappa B von Antony, Marie Lue, Noble-Orcutt, Klara E, Jensen, Jeffrey Lee, He, Fiona, Sachs, Zohar

Volltext

Proteasome Inhibition Attenuates Self-Renewal in Human Acute Myeloid Leukemia By Targeting NF-Kappa B in Leukemia Stem Cells von Antony, Marie Lue, Noble-Orcutt, Klara, Jensen, Jeffrey Lee, He, Fiona, Sachs, Zohar

Volltext

Abstract B34: Single cell RNA sequencing identifies the NRASG12V-mediated AML self-renewal signature von Sachs, Zohar, LaRue, Rebecca S., Noble, Klara, Rathe, Susan K., Sarver, Aaron L., Ha, Ngoc A., Largaespada, David A.

Volltext

Therapeutic Vulnerabilities in Acute Myeloid Leukemia (AML) with TP53 Alterations von Ogunsan, Oluwateniayo, Antony, Marie Lue, Noble-Orcutt, Klara E., He, Fiona, Sachs, Zohar

Volltext

Cell Type-Specific Effects of Crizotinib in Human Acute Myeloid Leukemia with TP53 Alterations von Antony, Marie Lue, Noble-Orcutt, Klara, Ogunsan, Oluwateniayo, He, Fiona, Sachs, Zohar

Volltext

Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome von Chang, Daniel, Noble-Orcutt, Klara E, Hudson, Wendy, Iyer, Aishwarya, Pomeroy, Emily, Eckfeldt, Craig E., Sarver, Aaron, Temiz, Nuri Alpay, Linden, Michael, Myers, Chad L, Largaespada, David A., Sachs, Zohar

Volltext

JAK/STAT Inhibition Targets TP53 altered Primary Human Acute Myeloid Leukemia Stem Cells von Antony, Marie Lue, Noble-Orcutt, Klara, Lee, Yoonku, Ogunsan, Oluwateniayo, Jensen, Jeffrey Lee, He, Fiona, Sachs, Zohar

Volltext

Abstract A56: TP53 mutant human AMLs stem cells rely on the proteasome for self-renewal von Antony, Marie Lue, Lee, Yoonkyu, Noble-Orcutt, Klara E, Sachs, Zohar

Volltext

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

Volltext