The feasibility and acceptability of engaging older adults living with multiple long-term conditions, frailty, and a recent deterioration in health in research: Findings from the L... von Hurst, Christopher, Dismore, Lorelle, Granic, Antoneta, Noble, Jane M, Hillman, Susan J, Witham, Miles D, Sayer, Avan A, Dodds, Richard M, Robinson, Sian M

Volltext

Attitudes and barriers to resistance exercise training for older adults living with multiple long-term conditions, frailty, and a recent deterioration in health: qualitative findin... von Hurst, Christopher, Dismore, Lorelle, Granic, Antoneta, Tullo, Ellen, Noble, Jane M, Hillman, Susan J, Witham, Miles D, Sayer, Avan A, Dodds, Richard M, Robinson, Sian M

Volltext

Feasibility of engaging older adults living with multiple long-term conditions, frailty, and a recent deterioration in health in a study of lifestyle: protocol for the LiLL-OPM stu... von Hurst, Christopher, Dismore, Lorelle, Granic, Antoneta, Tullo, Ellen, Noble, Jane M, Hillman, Susan J, Witham, Miles D, Sayer, Avan A, Dodds, Richard M, Robinson, Sian M

Volltext

Low rate of compliance with ergocalciferol therapy in vitamin‐D‐deficient patients with hip fracture von Noble, Jane M, McGuiness, Marjory, Glendenning, Paul

Volltext

Drugs for Alzheimer's disease von Warner, James, Butler, Rob, Noble, Jane M.

Volltext

Drugs for Alzheimer's disease von Warner, J., Butler, R., Noble, J. M

Volltext

The Structural Basis for Control of Eukaryotic Protein Kinases von Endicott, Jane A, Noble, Martin E.M, Johnson, Louise N

Volltext

Protein Kinase Inhibitors: Insights into Drug Design from Structure von Martin E. M. Noble, Endicott, Jane A., Johnson, Louise N.

Volltext

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK von Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.

Volltext

FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation von Wood, Daniel J, Lopez-Fernandez, J. Daniel, Knight, Leanne E, Al-Khawaldeh, Islam, Gai, Conghao, Lin, Shengying, Martin, Mathew P, Miller, Duncan C, Cano, Céline, Endicott, Jane A, Hardcastle, Ian R, Noble, Martin E. M, Waring, Michael J

Volltext

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1 von Rowland, Rhianna J., Heath, Richard, Maskell, Daniel, Thompson, Rebecca F., Ranson, Neil A., Blaza, James N., Endicott, Jane A., Noble, Martin E. M., Salamina, Marco

Volltext

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex von Rowland, Rhianna J., Korolchuk, Svitlana, Salamina, Marco, Tatum, Natalie J., Ault, James R., Hart, Sam, Turkenburg, Johan P., Blaza, James N., Noble, Martin E. M., Endicott, Jane A.

Volltext

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines von Coxon, Christopher R, Anscombe, Elizabeth, Harnor, Suzannah J, Martin, Mathew P, Carbain, Benoit, Golding, Bernard T, Hardcastle, Ian R, Harlow, Lisa K, Korolchuk, Svitlana, Matheson, Christopher J, Newell, David R, Noble, Martin E. M, Sivaprakasam, Mangaleswaran, Tudhope, Susan J, Turner, David M, Wang, Lan Z, Wedge, Stephen R, Wong, Christopher, Griffin, Roger J, Endicott, Jane A, Cano, Céline

Volltext

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition von Wood, Daniel J., Korolchuk, Svitlana, Tatum, Natalie J., Wang, Lan-Zhen, Endicott, Jane A., Noble, Martin E.M., Martin, Mathew P.

Volltext

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency von Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John

Volltext

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction von Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

Volltext

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System von Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.

Volltext

Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function von Bajaj, Jasmohan S, Cox, I Jane, Betrapally, Naga S, Heuman, Douglas M, Schubert, Mitchell L, Ratneswaran, Maiyuran, Hylemon, Phillip B, White, Melanie B, Daita, Kalyani, Noble, Nicole A, Sikaroodi, Masoumeh, Williams, Roger, Crossey, Mary M E, Taylor-Robinson, Simon D, Gillevet, Patrick M

Volltext

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase von Al-Khawaldeh, Islam, Al Yasiri, Mohammed J, Aldred, Gregory G, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J, Heptinstall, Amy B, Hobson, Stephen J, Jennings, Claire E, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P, Miller, Duncan C, Shrives, Harry J, de Souza, João V, Stewart, Hannah L, Temple, Max, Thomas, Huw D, Totobenazara, Jane, Tucker, Julie A, Tudhope, Susan J, Wang, Lan Z, Bronowska, Agnieszka K, Cano, Céline, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Hickson, Ian, Wedge, Stephen R, Willmore, Elaine, Noble, Martin E. M, Waring, Michael J

Volltext

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor von Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine

Volltext