An expandable, modular de novo protein platform for precision redox engineering von Hutchins, George H, Noble, Claire E M, Bunzel, H Adrian, Williams, Christopher, Dubiel, Paulina, Yadav, Sathish K N, Molinaro, Paul M, Barringer, Rob, Blackburn, Hector, Hardy, Benjamin J, Parnell, Alice E, Landau, Charles, Race, Paul R, Oliver, Thomas A A, Koder, Ronald L, Crump, Matthew P, Schaffitzel, Christiane, Oliveira, A Sofia F, Mulholland, Adrian J, Anderson, J L Ross

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Substrate promiscuity of a de novo designed peroxidase von Jenkins, Jonathan M.X., Noble, Claire E.M., Grayson, Katie J., Mulholland, Adrian J., Anderson, J.L. Ross

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease von Douangamath, Alice, Fearon, Daren, Gehrtz, Paul, Krojer, Tobias, Lukacik, Petra, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Aimon, Anthony, Ábrányi-Balogh, Péter, Brandão-Neto, José, Carbery, Anna, Davison, Gemma, Dias, Alexandre, Downes, Thomas D., Dunnett, Louise, Fairhead, Michael, Firth, James D., Jones, S. Paul, Keeley, Aaron, Keserü, György M., Klein, Hanna F., Martin, Mathew P., Noble, Martin E. M., O’Brien, Peter, Powell, Ailsa, Reddi, Rambabu N., Skyner, Rachael, Snee, Matthew, Waring, Michael J., Wild, Conor, London, Nir, von Delft, Frank, Walsh, Martin A.

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Tuning the Binding Affinity and Selectivity of Perfluoroaryl‐Stapled Peptides by Cysteine‐Editing von Verhoork, Sanne J. M., Jennings, Claire E., Rozatian, Neshat, Reeks, Judith, Meng, Jieman, Corlett, Emily K., Bunglawala, Fazila, Noble, Martin E. M., Leach, Andrew G., Coxon, Christopher R.

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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release von Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction von Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

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Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design von Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J, Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E, Joseph, Thomas L, Lakshminarayanan, Rajamani, Lane, David P, Noble, Martin E. M, Verma, Chandra S

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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency von Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John

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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase von Al-Khawaldeh, Islam, Al Yasiri, Mohammed J, Aldred, Gregory G, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J, Heptinstall, Amy B, Hobson, Stephen J, Jennings, Claire E, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P, Miller, Duncan C, Shrives, Harry J, de Souza, João V, Stewart, Hannah L, Temple, Max, Thomas, Huw D, Totobenazara, Jane, Tucker, Julie A, Tudhope, Susan J, Wang, Lan Z, Bronowska, Agnieszka K, Cano, Céline, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Hickson, Ian, Wedge, Stephen R, Willmore, Elaine, Noble, Martin E. M, Waring, Michael J

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach von Miller, Duncan C, Martin, Mathew P, Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R, Noble, Martin E M, Cano, Celine

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease von Douangamath, Alice, Fearon, Daren, Gehrtz, Paul, Krojer, Tobias, Lukacik, Petra, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Aimon, Anthony, Ábrányi-Balogh, Péter, Brandão-Neto, José, Carbery, Anna, Davison, Gemma, Dias, Alexandre, Downes, Thomas D, Dunnett, Louise, Fairhead, Michael, Firth, James D, Jones, S. Paul, Keeley, Aaron, Keserü, György M, Klein, Hanna F, Martin, Mathew P, Noble, Martin E.M, O’Brien, Peter, Powell, Ailsa, Reddi, Rambabu N, Skyner, Rachael, Snee, Matthew, Waring, Michael J, Wild, Conor, London, Nir, von Delft, Frank, Walsh, Martin A

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